Head-to-Head Review Finds Comparable Safety in Two Leading Drug Classes for IMIDs
The choice of advanced therapies for immune-mediated inflammatory disorders (IMIDs) needs to balance efficacy with safety. Janus kinase (JAK) inhibitors provide rapid and targeted immunomodulation, but safety concerns arose following the 2019 ORAL surveillance trial. This clinical trial compared tumor necrosis factor (TNF)-α antagonists with tofacitinib in older rheumatoid arthritis patients who had cardiovascular risk […]
How to Become a Nurse Practitioner in the USA: A Step-by-Step Guide
The healthcare system in the United States is changing quickly. Nurse practitioners (NPs) are at the forefront of this shift. If you want to start a career as an NP, it is necessary to understand the pathway, requirements, and opportunities. This guide will break down all the information you need to become a licensed NP […]
Autism and ADHD Assessments: Growing Inequities and Delays in 2025
The 2025 update highlights a growing crisis in the assessment and care of autism and Attention-Deficit/Hyperactivity Disorder (ADHD) in England. The situation has worsened since the Child of the North autism report, with delays in diagnosis continuing to rise. The 2024 update showed that around 306% more children are now waiting for the assessment of […]
Revolutionizing Bladder Cancer Care: FDA Approves INLEXZO
Non-muscle invasive bladder cancer (NMIBC) is classified as low, intermediate, or high risk, depending on size, multiplicity, and presence of carcinoma in situ (CIS), which occurs in approximately 10% of cases. The standard treatment for NMIBC is Bacillus Calmette-Guérin (BCG) immunotherapy, but some patients become unresponsive. After BCG failure, the remaining treatment option is radical […]
Bridging the knowledge gap: a mixed-methods study on general practitioners’ information needs for mHealth apps in hypertension treatment in Germany
BMC Health Serv Res. 2025 Sep 10;25(1):1195. doi: 10.1186/s12913-025-13192-9. ABSTRACT BACKGROUND: Hypertension remains a critical public health issue in Germany, affecting millions of individuals. Mobile health applications (mHealth apps) offer promising solutions for improving patient outcomes and adherence in hypertension management. Despite their advantages in healthcare, the adoption of mHealth apps by general practitioners (GPs) […]
Cofilin Pathway Alterations and CFL1 Variants as Contributors to Alcohol Use Disorder Phenotypes
Alcohol use disorder (AUD) arises from excessive alcohol use, characterized by a pathological drive to drink alcohol and cognitive inflexibility. Using the automated IntelliCage system, researchers used a mouse model of AUD to examine the biological structure of alcohol craving during forced withdrawal. In this model, <2 or ≥2 diagnostic criteria of AUD were applied […]
Phenotype-Driven Discovery of Therapeutic Perturbations by Graph-Based Causal Modeling
Phenotype-driven drug discovery (PDD) aims to identify the therapeutic treatments that reverse disease-like cellular states by direct observation of phenotypic reactions to the perturbations. Traditional methods rely on indirect algorithms, which are expensive and perform poorly when applied to large pertu therapeutic treatments that reverse disease-like cellular states through direct observation of phenotypic reactions to […]
Extrachromosomal DNA Shapes Intratumor Genetic and Spatial Heterogeneity in Glioblastoma
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. It has a poor prognosis with a median survival of about 14 months, although with maximal treatment. Genetic heterogeneity caused by extrachromosomal DNA (ecDNA) is the main barrier to therapeutic advancement. EcDNA is separated during cell division and frequently contains oncogenes like […]
UNICEF Feeding Profit 2025 Report Warns of Rising Childhood Obesity and Unhealthy Food Environments
UNICEF has published its Child Nutrition Report 2025, entitled “Feeding Profit: How Food Environments Are Failing Children,” which presents a stark picture of the global nutrition crisis affecting millions of children. The report describes the significant increase in overweight and obesity, the growing dominance of ultra-processed foods, and the influence of the food and beverage […]
AMWA’s Commitment to Workplace Safety for Women Physicians: A Path Toward Equity and Protection
Am J Ind Med. 2025 Oct;68(10):920-925. doi: 10.1002/ajim.70016. Epub 2025 Aug 18. ABSTRACT A safe workplace goes beyond simply following regulations, it is a basic right that shields employees from physical, emotional, and psychological harm. This position paper looks at the various aspects of workplace safety, especially for women physicians, highlighting the need for an […]
