The Mobile Constant, a Self-Reported Method for Shoulder Function Evaluation: Development and Validation Study
J Med Internet Res. 2025 Sep 3;27:e63308. doi: 10.2196/63308. ABSTRACT BACKGROUND: Shoulder pain is a highly prevalent musculoskeletal disorder that severely compromises patients’ quality of life. The Constant-Murley Scale (CMS) is a well-established method for shoulder function evaluation. However, the necessity of clinician involvement constrains its utility in continuous monitoring. Recent improvements in human pose […]
Mobile Telehealth Intervention to Support Care Partners of Patients With Alzheimer Disease and Related Dementias (I-CARE 2): Protocol for a Randomized Effectiveness Clinical Trial
JMIR Res Protoc. 2025 Sep 3;14:e73387. doi: 10.2196/73387. ABSTRACT BACKGROUND: Nearly all individuals with Alzheimer disease and related dementias (ADRD) experience behavioral and psychological symptoms of dementia (BPSD), which include symptoms such as agitation, wandering, delusions, and hallucinations. Care partners (a person, often a family member, who provides care and support to someone with ADRD) […]
Position-invariant icon remapping facilities search performance in foldable smartphones through the contribution of contextual cueing
Cogn Res Princ Implic. 2025 Sep 1;10(1):57. doi: 10.1186/s41235-025-00668-9. ABSTRACT Enabling smartphones to be foldable provides an effective approach to achieving both portability and large screens. Notably, switches between closed and open states in using foldable smartphones are accompanied by icon remapping, which can decrease smartphone usability if it fails to match usage expectations. This […]
Genomic Alterations in Triple-Negative Breast Cancer Among African American Women
Triple-negative breast cancer (TNBC) commonly occurs among African American (AA) women as compared to any other racial group. This subtype shows 10% to 15% cases of all breast cancer diagnoses, and the absence of expression of the progesterone and estrogen receptors identifies it. The epidemiology of TNBC shows a high incidence with 25.2 cases per […]
Honey-Derived Bioactive Compounds as Modulators of Alzheimer’s Disease Pathology
Alzheimer’s disease (AD) is a progressive neurological disease. It causes memory loss, behavioral disturbance, and cognitive decline. Many factors contribute to the pathology of AD, like chronic neuroinflammation, oxidative stress, accumulation of pathological proteins like hyperphosphorylated tau tangle and amyloid-beta (Aβ) plaques, and apoptosis. Current therapeutic methods are symptomatic, and there is an urgent need […]
Study Finds Aspirin Alone Works as Well as Dual Therapy After Heart Bypass
Patients undergoing coronary-artery bypass grafting (CABG) following ACS are usually recommended to use aspirin lifelong to decrease the chance of adverse events. Present guidelines approved the use of dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor, such as ticagrelor or clopidogrel. The evidence for DAPT specifically in CABG patients remains limited compared with […]
The Mediating Role of Academic Resilience and Cognitive Test Anxiety in the Association Between Smartphone Addiction and Academic Achievement
Brain Behav. 2025 Sep;15(9):e70800. doi: 10.1002/brb3.70800. ABSTRACT OBJECTIVES: Smartphone addiction is the loss of self-control resulting from excessive use of smartphones and is the most challenging addiction to daily life among technology addictions. Some studies explain the relationship between smartphone addiction and academic achievement. The purpose of this research is to examine the mediating effect […]
Study protocol for a prospective, randomized controlled confirmatory clinical investigation to evaluate the safety and efficacy of a multidisciplinary digital therapeutics in patients with patellofemoral pain syndrome
Trials. 2025 Sep 1;26(1):328. doi: 10.1186/s13063-025-09030-2. ABSTRACT BACKGROUND: Patellofemoral pain is a prevalent knee condition affecting up to 40% of individuals, especially females aged teens to 50 s. Standard treatments, including exercise therapy, often yield insufficient long-term results, partly due to low compliance and psychological factors like depression and catastrophizing of pain. A digital therapeutics […]
Mobile App-Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial
JAMA Netw Open. 2025 Sep 2;8(9):e2529762. doi: 10.1001/jamanetworkopen.2025.29762. ABSTRACT IMPORTANCE: Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message-based intervention strategies could address this gap but lack evidence of benefit on multiple risk factors. OBJECTIVE: To evaluate the effectiveness of a mobile message-based intervention in controlling […]
Dissecting Complex Disease Genetics via eQTLs in Stimulated iPSC-Derived Macrophages
The noncoding regions of the genome are frequently associated with disease-associated mutations. Expression quantitative trait loci (eQTL) mapping can identify any changes in gene expression caused by these variants. Each human gene is currently known to have at least one eQTL, found in a wide variety of cell types and human tissues. Both bulk RNA […]
