Dissecting Complex Disease Genetics via eQTLs in Stimulated iPSC-Derived Macrophages
The noncoding regions of the genome are frequently associated with disease-associated mutations. Expression quantitative trait loci (eQTL) mapping can identify any changes in gene expression caused by these variants. Each human gene is currently known to have at least one eQTL, found in a wide variety of cell types and human tissues. Both bulk RNA […]
MIND Diet and Neurodegeneration: Associations with Hippocampal Sclerosis in Older Adults
Hippocampal sclerosis (HS) is an age-related degenerative condition characterized by neuronal loss and astrogliosis in the subiculum and the Cornu Ammonis 1 (CA1) region. It affects around 20% cognitively impaired individuals. It causes dementia over Alzheimer’s disease (AD), frequently coexisting with AD-pathology and limbic-predominant TDP-43 encephalopathy (LATE-NC). Since modifiable risk factors influence the risk of […]
Polyphenols in Alzheimer’s Disease: Molecular Insights and Therapeutic Potential
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and remains a major public health challenge. Current drug treatments, including cholinesterase inhibitors and memantine, provide symptomatic relief but do not halt disease progression. Recently, food-derived polyphenols found in fruits, vegetables, tea, coffee, and wine have been identified as potential therapeutic agents due […]
Rapid access microscopy and real-time case discussion via a secure messaging app improves diagnostic accuracy and management of acute hot swollen joints
BMJ Open Qual. 2025 Sep 1;14(3):e003417. doi: 10.1136/bmjoq-2025-003417. ABSTRACT Patients with acute swollen joints are often presumed to have septic arthritis, leading to intravenous antibiotics and arthroscopic washout. Previously at our centre, joint fluid aspirates often lacked crystal analysis, resulting in excess culture-negative septic arthritis diagnoses. We developed a ‘Hot Joint Pathway’, hypothesising that since […]
“Clarithromycin vs. Surgery: New Trial Tests Best Approach for Chronic Sinusitis”
Chronic rhinosinusitis (CRS) affects approximately 9% of adults worldwide and substantially impairs quality of life. Symptoms include nasal obstruction, discharge, facial pain, anosmia, and sleep disturbance, sometimes more severely than angina or chronic respiratory disease. Acute exacerbations are common, and about one-third of patients attending ENT clinics fail to respond to standard treatments, including intranasal […]
Impact of Non-Antibiotic Medications on Antimicrobial Resistance Emergence in Escherichia Coli
Antimicrobial resistance (AMR) poses a major threat to public health. While the overuse of antibiotics remains the primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute to resistance. Public health is under serious risk from the emergence and spread of organisms and genes that are resistant to antibiotics. The misuse of antibiotics […]
Recurrent Emergence of Yersinia pestis: Ancient DNA and the Role of Eurasian Reservoirs
Yersinia pestis causes plague and has triggered multiple pandemics throughout history. Its exact origin and modes of transmission remain unclear. Paleogenomic research reveals that the pathogen has been present in Eurasia since the Neolithic, indicating a complex zoonotic and human history. The first pandemic (541-750 CE) marked the shift of plague from localized outbreaks to […]
A Mobile App (CareFit) Supporting Physical Activity for Informal Carers of People With Dementia: Mixed Methods Feasibility and Adaptation Study
J Med Internet Res. 2025 Aug 29;27:e56739. doi: 10.2196/56739. ABSTRACT BACKGROUND: Informal carers are critical in looking after people with dementia. The value of all informal care as a total in the United Kingdom is now estimated to be £184 billion (US $249 billion). However, many carer groups are inadequately supported and face poor mental […]
The Mexican Version of the Interactive mHealth App Usability Questionnaire (Mx-MAUQ) in Women With Breast Cancer: Instrument Validation Study
J Med Internet Res. 2025 Aug 29;27:e72215. doi: 10.2196/72215. ABSTRACT BACKGROUND: Successful eHealth applications require careful assessment to ensure their ease of use, usefulness, and user satisfaction. Responsive web applications are eHealth tools that operate on any internet-enabled device across all browsers. Psychometrically valid assessment tools are essential for effectively evaluating these applications, yet no […]
Identifying and Evaluating Mobile and Web Apps for Patients to Manage Hidradenitis Suppurativa: Systematic Search in App Stores and Content Analysis
JMIR Mhealth Uhealth. 2025 Aug 29;13:e69030. doi: 10.2196/69030. ABSTRACT BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas in intertriginous sites. It significantly impacts patients’ quality of life. Early diagnosis and timely treatment are essential for disease control. Recurrent flares, suboptimal therapies, and prolonged misdiagnosis place a […]
