Propolis Treated Rats Shows Improvement in Cognitive Function

If the stress is long term, then this is unhealthy to both the minds as well as the bodies of the suffering individuals. One potential study work shows how especially significant life events may also influence people’s mental and cognitive functions, for example, alter their memory and sometimes lead to the development of mental health issues.

Research has found a relationship between stress during adolescent and puberty with stress in an adult age and poor memory. Such evidence suggests that enhancing knowledge of how the possibility of reducing stress may hence help in enhancing the health welfare of people all over the world.

In a study conducted at Ibn Tofail University in Morocco the efficacy of phytotherapy remedies for lessening mild stress and enhancing cognitive function has been investigated. The final piece in their research that was released in the Neuroscience and Behavioral Physiology journal demonstrates that a highly concentrated extract from the resin of a plant like cactus in Morocco enhances the ability of male rats with CMS.

M. Chakit & I. Kherrab & et al have penned down in their paper, “Prepuberty and adolescence criticality could be associated with disease development and brain and memory dysfunctions in the adult age. This work is intended to evaluate the impact of unpredictable chronic mild stress (UCMS) during pre-puberty and adolescence and propolis supplementation on cognitive abilities of adult male rats.

Propolis in fact is a substance which bees create while preparing resin from plants. To this end, Kherrab, Chakit and their colleagues looked at the impact of propolis generated from Euphorbia resinifera, a tree located in Morocco that yields resin of some medicinal value.

Alcoholic extracts of the propolis that bees produced from this plant were extracted by methanol used as an active component. The researchers then tried its efficacy in male adult rats by using this methanolic extract. Firstly, they divided 18 rats into 3 experimental groups: It was observed three groups of animals, the non-stressed control group, the stressed group that did not receive the extract and the experimental group. 

The first group consisted of 6 rats, which was kept unfixed and was not exposed to stressors and the second and the third group of rats were exposed two stressors daily for 6 weeks.

Altogether, the researchers did discover that the administered propolis helped the memory of stressed rats and helped preserve the neurons in the CA1 and CA3 regions of the hippocampus. Besides, it was observed that rats that received the supplement after been stressed had higher social contact compared to the stressed rats that were put in the same cage with other unfamiliar rats when compared to rats that had the propolis extract.

Reference:

Propolis from a Morocco-native plant found to improve cognitive function in male rats experiencing chronic mild stress

DOI: 10.1007/s11055-024-01659-x

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