Starting dose:
Patients who are not using theophylline: 5 to 7 mg/kg Intravenous/orally; maximum 25 mg/minute Intravenous
Aminophylline: 6 to 7 mg/kg intravenous infusion over 20 mins. Maintenance dose:
0.4 to 0.6 mg/kg hourly intravenous or orally 4.8 to 7.2 mg/kg (extended release) every 2 times a day to maintain 10-15 mg/L
Smokers: a dose of 0.79 mg/kg/hr Intravenous for 12 hours following loading dosage, thereafter 0.63 mg/kg/hr or Orally 5 mg/kg (extended release) every 3 times a day.
Coadministration with Cimetidine, erythromycin, ciprofloxacin, and macrolides inhibit theophylline clearance: 0.2 to 0.3 mg/kg/hr Intravenous or Orally (extended release) every 1-2 times a day
CHF: 0.39 mg/kg/hr Intravenous for 12 hours following loading dosage, thereafter 0.08 to 0.16 mg/kg/hr.
Dose Adjustments
Dosage Modifications
liver impairment: After loading dosage, 0.39 mg/kg/hr Intravenously for following 12 hours, thereafter 0.08 to 0.16 mg/kg/hr
5 ml of this drug every 3 to 5 hours is recommended, which should be at most 30 ml daily This drug is used for treating bronchial congestion and bronchospasm, which are associated with acute and chronic bronchitis
When nebulizer solution is prescribed, the recommended dose is 2.5 mg per day, 2 or 3 times as needed. For quick relief, a 1.25-5 mg dose is given with a time interval of 4 to 8 hours as required
In the case of an Aerosol metered dose inhaler, the dose is 180 mcg, which is equivalent to 2 puffs of inhalation orally with a time interval of 4 or 8 hours, which should not cross the limit of 12 inhalations in a day
In the case of a powdered dose inhaler, the dose is 180 mcg, which is equivalent to 2 puffs of inhalation orally with a time interval of 4 or 8 hours, which should not cross the limit of 12 inhalations in a day. One inhalation that is 90 mcg with a time interval of 4 hours is sufficient in a few patients
When oral tablets are prescribed, the dose is 2-4 mg 2 times a day, and few patients are relieved with 4 mg twice a day. Limit is 32 mg per day
The extended-release tablet dose is 8 mg via oral administration twice a day, whereas 4 mg twice a day is sufficient in a few patients
Indicated for bronchospasm prophylaxis (Allergen/Exercise- induced) Give a 20 mg dose as a single administration between 10 to 15 minutes before engaging in exposure to allergens or exercise Ensuring it is not administered later than 1 hour
Orally:
2.5 mg 3-4 times daily orally
Maintenance: 5 mg thrice a day orally every 6hr; reduce dose to 2.5 mg every 6hr
Should not exceed more than 15 mg/Day
Sub cutaneous:
0.25 mg every 15-30min 3 divided doses when required in lateral deltoid; should not exceed 0.5mg/4hr
Aerosol Metered dose inhaler
<4 years: Safety and efficacy not established
>4 years: 90-180mcg inhaled orally every 4 to 6 hours. Do not exceed 12 inhalations for 24 hours
Powder Metered dose inhaler
<4 years: Safety and efficacy not established
>4 years: 90-180mcg inhaled orally every 4 to 6 hours. Do not exceed 12 inhalations for 24 hours
Tablet
<6 years:0.3-0.6mg/kg/day orally divided every 8 hours
6-12 years: 2mg orally every 6-8 hours
>12 hours: 2-4mg orally every 6-8 hours. Do not exceed 32mg/day
Nebulizer solution
<2 years:0.2-0.6mg/kg/day divided every 6-8 hours
2-12 years(<15kg): 2.5mg/0.5ml every 6-8 hours
>12 years:2.5mg every 6 to 8 hours when necessary
Bronchospasm starting dose:
theophylline has not been given in the last 24 hrs: 5-7 mg/kg Intravenous/orally; intravenous infusion over 20 to 30 min.
Maintenance dose:
1.5-6 months: Give 0.5 mg/kg/hr Intravenously or Orally 10 mg/kg daily in the divided doses
6-12 months: Give 0.6 to 0.7 mg/kg/hr Intravenously or Orally 12-18 mg/kg daily in the divided doses.
1-9 yrs: Give 1 mg/kg hourly Intravenously or Orally 8 mg/kg (extended release) every 3 times a day
9 to 12 yrs: Give 0.8 to 0.9 mg/kg hourly Intravenously or Orally 6.4 mg/kg (extended release) every 3 times a day
12 to 16 yrs: Give 0.7 mg/kg hourly Intravenously or Orally 5.6 mg/kg (extended release) every 3 times a day
In children with asthma who are four and above, the dose is 90-180 mcg, which is 1-2 puffs that is inhaled orally every 4 or 6 hours
Powdered metered dose inhaler use should be 180 mcg, which is two puffs inhaled orally every 4 or 6 hours. The limit is 12 inhalations per day. A few patients are relieved with one inhalation that is 90 mcg for every 4 hours
Nebulizer solution is used in children who are between 2 and 12 with a weight below 15 kg, and the dose is 2.5 mg/0.5 mL, that is, 0.5% solution for every 6 or 8 hours. The limit is 10 mg, which is four vials per day
Nebulizer solution is used in children who are between 2 and 12 with a weight above 15 kg, and the dose is 2.5 mg/3 mL every 6 or 8 hours via oral inhalation. Limit is 10 mg per day
Nebulizer solution is used in children who are above 12, and the dose is 2.5 mg, that is, one vial for every 6 or 8 hours via oral inhalation. Limit is 10 mg per day
The delivery flow rate is adjusted every 5 to 15 minutes
When AccuNeb is prescribed in children who are between 2 and 12, the dose is one vial that is 1.25 or 0.63 mg/vial for every 6 or 8 hours via oral inhalation with a nebulizer for the duration of 5 to 15 minutes. Limit is 5 mg per day
When tablets are prescribed in children who are over six years old, the dose is 0.3-0.6 mg/kg per day via oral administration divided three times a day. Limit is 12 mg per day
In children between 6 and 12, oral administration of albuterol tablets with a dose of 2 mg every 6 or 8 hours can be raised slowly to 24 mg per day or more in divided doses
2-4 mg tablets via oral administration in children who are above 12 for every 6 or 8 hours. Limit is 32 mg per day
Dose of 4 mg extended-release tablet via oral administration in children between 6 and 12 years twice a day. Limit is 24 mg per day
Dose of 2 -4 mg oral extended-release tablet for every 6 or 8 hours in children who are above 14 years. Limit is 32 mg per day
In children who are between 2 and 6 years old, the dose is 0.1 mg/kg via oral administration for every 8 hours when initiated, with a limit of 2 mg/kg for every eight hours. If required, it may raised to 0.2 mg/kg for every 8 hours with a limit of 4 mg, which is 10 mL for every 8 hours
In children between 6 and 14 years, the dose is 2 mg, that is, 5 mL via oral administration for every 6 or 8 hours, which is raised slowly to 24 mg per day or more in divided doses
In children above 14, the dose is 2-4 mg via oral administration every 6 or 8 hours with a limit of 32 mg per day
In the management of exercise-induced bronchospasm, an aerosol or powder metered dose inhaler with 180 mcg dose, which is two puffs, is inhaled half an hour before exercise
Indicated for bronchospasm prophylaxis (Allergen/Exercise-induced) Age 2 years: Give a 20 mg dose as a single administration between 10 to 15 minutes before engaging in exposure to allergens or exercise Ensuring it is not administered later than 1 hour
PO
Below 12 years: 0.05mg/kg thrice a day; increase when required, should not exceed more than 5mg/day
between 12-15years: 2.5mg orally every 6-hr trice a day; should not exceed more than 7.5 mg/day
Above 15 years: 5mg/dose orally every 8-hr trice a day; reduce the dose to 2.5mg every 6 hr; should not exceed more than 15mg/24hr SC
Below 12 years: 0.005-0.01mg/kg every 15-20min trice a day; following every 2-6hrs when required.
Above 12 years: 0.25mg every 15-30min three divided doses when required in lateral deltoid; should not exceed 0.5mg/4hr
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Digital Certificate PDF
On course completion, you will receive a full-sized presentation quality digital certificate.
medtigo Simulation
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
medtigo Points
medtigo points is our unique point redemption system created to award users for interacting on our site. These points can be redeemed for special discounts on the medtigo marketplace as well as towards the membership cost itself.
Community Forum post/reply = 5 points
*Redemption of points can occur only through the medtigo marketplace, courses, or simulation system. Money will not be credited to your bank account. 10 points = $1.
All Your Certificates in One Place
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
