Complex Partial Seizures

Updated: September 30, 2024

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Background

A complex partial seizure, called Focal Onset Impaired Awareness Seizure, is a seizure that originates in just one spot in the brain.

It is most found in the temporal lobe, although it may arise from any other site also. These seizures reflect an impairment of consciousness and vary from 30 seconds to several minutes in how long they last.

Epidemiology

Epilepsy is present in the prevalence of 0.5 to 1 person per 100 of the total population. Focal impaired awareness seizures occur in 35% of people with epilepsy. Partial seizures are more common in those countries where cysticercosis is prevailing.

In people less than 60 years old, partial epilepsy or focal impaired awareness seizures accounts for 20 per 100,000 person-years. This figure increases to 80 per 100,000 person-years in persons aged 60-80 years.

Anatomy

Pathophysiology

Focal onset impaired awareness seizures or complex partial seizures occur from a given focus mainly the temporal lobe. Their pathophysiology involves abnormal electrical activity that originate from fixed points in the cortex and interfere with normal cortical discharge. This interferes with the brain circuits that regulate consciousness, memory, and behavior while at the same time also obliterating awareness with corresponding automatisms. Examples are developmental factors; Structural disorders such as tumour or lesion in the brain, abnormalities in GABA or glutamate concentration, and genetic predisposition to modify ion channels or synaptic rules.

Etiology

Often called focal onset impaired awareness seizures, complex or partial seizures usually originate from an abnormal electrical activity site within the brain, although they may arise from any lobe, most commonly, but not exclusively, from the temporal lobe. Acquired conditions, such as head trauma (traumatic or linked to rheumatoid arthritis), strokes, or infections such as encephalitis or meningitis, tumors, and abnormalities in blood vessel formation, can cause it. It is feasible to treat developmental disorders and neurodegenerative illnesses such as Alzheimer’s as causes of these seizures. In certain frameworks, somatic genetic mutations involving ion channels or neurotransmitter regulation cause a tendency toward developing epilepsy in a person.

Another condition is mesial temporal sclerosis, scarring of the hippocampus, which closely relates to developing complex partial seizures. In some, the cause is idiopathic and obvious structural or genetic abnormalities are not observed.

Genetics

Prognostic Factors

Prognostic factors of complex partial seizures referred to as focal seizures with impaired awareness have several underlying prognostic factors that influence the long-term outcome. These include factors such as the etiology of seizures and their underlying causes. For example, in cases where the etiology is based on structural abnormalities within the brain, such as hippocampal sclerosis or tumors, the prognosis is usually inferior compared to those cases which lack a well-defined etiology.

Other risk factors include the duration and frequency of seizures; this incidence of frequent or prolonged seizures is directly related to drug resistance. Early onset during seizure activity, particularly in childhood, increases the risk for cognitive and developmental disabilities.

Clinical History

Age Group:

This type of seizures occurs irrespective of the age group.

However, they often most frequently appear in adolescents and adults.

Physical Examination

Neurological examination

Check for autonomic signs

Age group

Associated comorbidity

Depression

Anxiety

Cognitive impairment

Psychosis

Associated activity

Acuity of presentation

Onset:

Gradual or abrupt: These usually have a gradual onset rather than an abrupt one as generalized seizure are. Affected persons may have a pre-seizure aura that could involve abnormal sensations or a feeling of a rising epigastric discomfort.

Acuity:

Subacute or acute presentation: These seizures may present sub acutely or suddenly and may follow a pattern in patients with epilepsy.

Postictal confusion: Post the seizure, there may be a period of confusion, drowsiness or lethargy; that may last minutes to hours depending on the individual.

Differential Diagnoses

Psychogenic Non-Epileptic Seizures (PNES)

Transient Ischemic Attacks (TIAs)

Migraine Auras

Dementia and Cognitive Disorders

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

Initial Evaluation and Diagnosis:

Establish the diagnosis by detailed history, physical examination, and diagnostic investigations like EEG and MRI.

Triggering factors and other comorbid conditions if present.

Pharmacotherapy First-Line

AEDs: Drug management generally depends on age of patient, comorbidities, and the nature of seizures.

The most used first-line AEDs for focal seizures are

Carbamazepine drugs are effective and commonly used in focal seizure.

Lamotigrine: Lamotrigine is relatively safer drug, compared to other antiepileptic drugs.

Levetiracetam: Highly active; preferable for its rather favorable side effect profile.

Oxcarbazepine: Such as carbamazepine but with less side effects. Topiramate: Potent psychotropic medication well known for the neuropsychiatric side reactions.

Alternative Therapies: If first-line AEDs are either inadequate or not tolerated, then the following may be considered:

Gabapentin: Used more in neuropathic pain than in epilepsy because of lesser side effects.

Lacosamide: This is one of the recently developed AEDs with a reasonable safety profile.

Perampanel: One of the newest AEDs. Useful mainly for the management of focal seizures.

Surgical Intervention

It is taken into consideration in a patient with refractory seizures (uncontrolled by drugs) and for those patients where an epileptogenic focus is localized.

Surgery can include the following:

Resective surgery: Excision of the seizure focus, for instance, via temporal lobectomy.

VNS: It is an implantable device which stimulates the vagus nerve to help reduce the number of seizures.

RNS: That detects a seizure and sends electrical stimuli to prevent the seizure from happening

Lifestyle Changes

Education: Educate the patient on what might be “triggers” for seizure activity and prevention strategies, such as non-injurious activities.

Nutritional interventions: Patients may need a ketogenic diet in resistant patients to conventional therapy.

Sleep hygiene: Encourage normal, adequate sleep practices to reduce excessive seizure activation.

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

lifestyle-modifications-in-treating-complex-partial-seizures

Routine and structure:

Structured Routine: Have a regular daily routine as interruptions and stress can cause seizures.

Visual Schedules: Use visual schedules or lists that assist in organizing daily tasks such as cleaning.

Sensory Overload:

Calm environment: When constructing a peaceful environment for an epilepsy patient it means minimizing the noise level and providing a dim light environment.

Limit Screen Time: Lights or screens that are flashing can cause seizures in a few individuals.

Prepare the emergency:

Seizure Action Plan: Prepare for it an action procedure that will particularly outline what should be done when a seizure occurs.

It is very important that the family and caregivers taking care of the person are all informed about this plan.

Medical Alert: Discuss with the patient the use of a medical alert or device that can provide information in the event of a seizure to others.

Resources within Communities:

Support Groups: Shared experiences, support groups that are specifically designed for epilepsy.

Professional Counselling: Advice from healthcare professionals will guide one in making the best decisions and create a good number of supportive ideas individualized within a given setting.

Effectiveness of Anticonvulsants in treating Complex partial seizures

Carbamazepine (Tegretol)

Stabilizes hyperexcitable neuronal membranes due to sodium channel blockade.

Often first-line treatment.

Reassess for dizziness, drowsiness, and possible blood dyscrasias.

Lamotrigine (Lamictal)

Blocks voltage-sensitive sodium channels and decreases glutamate release.

Generally tolerated and helpful for both focal and generalized seizure activity.

Risk of skin rashes including Stevens-Johnson syndrome; especially concerning with rapid titration.

Levetiracetam (Keppra)

Binds to SV2A protein that modulates synaptic neurotransmitter release.

Favorable side-effect profile. May cause behavior disturbances in some patients.

Valproate (Depakote)

Increases GABA levels and inhibits sodium channels.

Efficacy across a wide spectrum

Monitor liver function, platelet count.

Teratogenicity is possible when used during pregnancy.

Topiramate (Topamax)

Blocks sodium channels, enhances GABA activity, antagonizes glutamate receptors.

Can cause cognitive, weight loss and metabolic acidosis side-effects.

Phenytoin (Dilantin)

It may stabilize neuronal membranes via sodium channel blockade.

Long history of use but not favored much because of side effects, such as gum hypertrophy and drug interactions.

role-of-intervention-with-procedure-in-treating-complex-partial-seizures

Drug-Resistant Epilepsy: Usually, surgery is an option when a patient fails to respond to two or more medications designed to control seizures.

Localized Epileptogenic Zone: Seizures from a defined, localized part of the brain are more likely to succeed with surgery.

Types of Surgery
Resective Surgery: This operation involves the removal of some of the brain tissue where seizures arise.
Common practices are:
Temporal Lobectomy: A portion of the temporal lobe is removed to treat patients suffering from temporal lobe epilepsy.
Extratemporal Resection: External fields beyond the temporal lobe must be removed in patients subjected to focal epilepsies of different forms.

role-of-management-in-treating-complex-partial-seizures

Phase of Prevention and Evaluation of Risks (Pre-convulsive):

Activation Triggers:

Stress, lack of sleep and other stimuli capable of triggering seizure.

Education: Instructing the patient and/or the family on the types of seizures, recognition of their characteristics and probable outcome. Lifestyle Modification: Reported good health practice often through personal care, observing simple hygiene practices, maintaining proper sleeping habits, good management of stress and avoiding situations that may cause one to have a seizure.

Encourage that patient to use their AED as prescribed to avoid the seizure.

Care: When an attack begins, the person is given shielding interventions that include safeguarding them and, if possible, placing the person on their side.

Recovery and Evaluation phase:

Observation: For signs that indicate confusion, fatigue or amnesia which manifests itself after the seizure has taken place.

Evaluation: The need for further research will be underlined while speaking about triggering elements and the assessment will examine the outcomes of the seizure for the patient.

Communication: The Scenario describes what happened in the patient during the seizure and how the treatment or management strategies could have been different.

Long-Term Management:

Medications: Modifying or optimizing the strategies to increase AED duration due to the characteristics, distribution, and other consequences of seizures.

Follow-Up: To properly track the seizure status, a neurologist must get systematic appointments to follow up on how well the medicine works.

Psychological/psychosocial: Assistance in taking advantage of counselling, support group, and psychotherapy on the psychosocial or social aspect in relates to the condition.

Advanced Therapies

Evaluation: Consider VNS along with RNS, as well as exploring other surgical options as well.

Medication

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Complex Partial Seizures

Updated : September 30, 2024

Mail Whatsapp PDF Image



A complex partial seizure, called Focal Onset Impaired Awareness Seizure, is a seizure that originates in just one spot in the brain.

It is most found in the temporal lobe, although it may arise from any other site also. These seizures reflect an impairment of consciousness and vary from 30 seconds to several minutes in how long they last.

Epilepsy is present in the prevalence of 0.5 to 1 person per 100 of the total population. Focal impaired awareness seizures occur in 35% of people with epilepsy. Partial seizures are more common in those countries where cysticercosis is prevailing.

In people less than 60 years old, partial epilepsy or focal impaired awareness seizures accounts for 20 per 100,000 person-years. This figure increases to 80 per 100,000 person-years in persons aged 60-80 years.

Focal onset impaired awareness seizures or complex partial seizures occur from a given focus mainly the temporal lobe. Their pathophysiology involves abnormal electrical activity that originate from fixed points in the cortex and interfere with normal cortical discharge. This interferes with the brain circuits that regulate consciousness, memory, and behavior while at the same time also obliterating awareness with corresponding automatisms. Examples are developmental factors; Structural disorders such as tumour or lesion in the brain, abnormalities in GABA or glutamate concentration, and genetic predisposition to modify ion channels or synaptic rules.

Often called focal onset impaired awareness seizures, complex or partial seizures usually originate from an abnormal electrical activity site within the brain, although they may arise from any lobe, most commonly, but not exclusively, from the temporal lobe. Acquired conditions, such as head trauma (traumatic or linked to rheumatoid arthritis), strokes, or infections such as encephalitis or meningitis, tumors, and abnormalities in blood vessel formation, can cause it. It is feasible to treat developmental disorders and neurodegenerative illnesses such as Alzheimer’s as causes of these seizures. In certain frameworks, somatic genetic mutations involving ion channels or neurotransmitter regulation cause a tendency toward developing epilepsy in a person.

Another condition is mesial temporal sclerosis, scarring of the hippocampus, which closely relates to developing complex partial seizures. In some, the cause is idiopathic and obvious structural or genetic abnormalities are not observed.

Prognostic factors of complex partial seizures referred to as focal seizures with impaired awareness have several underlying prognostic factors that influence the long-term outcome. These include factors such as the etiology of seizures and their underlying causes. For example, in cases where the etiology is based on structural abnormalities within the brain, such as hippocampal sclerosis or tumors, the prognosis is usually inferior compared to those cases which lack a well-defined etiology.

Other risk factors include the duration and frequency of seizures; this incidence of frequent or prolonged seizures is directly related to drug resistance. Early onset during seizure activity, particularly in childhood, increases the risk for cognitive and developmental disabilities.

Age Group:

This type of seizures occurs irrespective of the age group.

However, they often most frequently appear in adolescents and adults.

Neurological examination

Check for autonomic signs

Depression

Anxiety

Cognitive impairment

Psychosis

Onset:

Gradual or abrupt: These usually have a gradual onset rather than an abrupt one as generalized seizure are. Affected persons may have a pre-seizure aura that could involve abnormal sensations or a feeling of a rising epigastric discomfort.

Acuity:

Subacute or acute presentation: These seizures may present sub acutely or suddenly and may follow a pattern in patients with epilepsy.

Postictal confusion: Post the seizure, there may be a period of confusion, drowsiness or lethargy; that may last minutes to hours depending on the individual.

Psychogenic Non-Epileptic Seizures (PNES)

Transient Ischemic Attacks (TIAs)

Migraine Auras

Dementia and Cognitive Disorders

Initial Evaluation and Diagnosis:

Establish the diagnosis by detailed history, physical examination, and diagnostic investigations like EEG and MRI.

Triggering factors and other comorbid conditions if present.

Pharmacotherapy First-Line

AEDs: Drug management generally depends on age of patient, comorbidities, and the nature of seizures.

The most used first-line AEDs for focal seizures are

Carbamazepine drugs are effective and commonly used in focal seizure.

Lamotigrine: Lamotrigine is relatively safer drug, compared to other antiepileptic drugs.

Levetiracetam: Highly active; preferable for its rather favorable side effect profile.

Oxcarbazepine: Such as carbamazepine but with less side effects. Topiramate: Potent psychotropic medication well known for the neuropsychiatric side reactions.

Alternative Therapies: If first-line AEDs are either inadequate or not tolerated, then the following may be considered:

Gabapentin: Used more in neuropathic pain than in epilepsy because of lesser side effects.

Lacosamide: This is one of the recently developed AEDs with a reasonable safety profile.

Perampanel: One of the newest AEDs. Useful mainly for the management of focal seizures.

Surgical Intervention

It is taken into consideration in a patient with refractory seizures (uncontrolled by drugs) and for those patients where an epileptogenic focus is localized.

Surgery can include the following:

Resective surgery: Excision of the seizure focus, for instance, via temporal lobectomy.

VNS: It is an implantable device which stimulates the vagus nerve to help reduce the number of seizures.

RNS: That detects a seizure and sends electrical stimuli to prevent the seizure from happening

Lifestyle Changes

Education: Educate the patient on what might be “triggers” for seizure activity and prevention strategies, such as non-injurious activities.

Nutritional interventions: Patients may need a ketogenic diet in resistant patients to conventional therapy.

Sleep hygiene: Encourage normal, adequate sleep practices to reduce excessive seizure activation.

Neurology

Routine and structure:

Structured Routine: Have a regular daily routine as interruptions and stress can cause seizures.

Visual Schedules: Use visual schedules or lists that assist in organizing daily tasks such as cleaning.

Sensory Overload:

Calm environment: When constructing a peaceful environment for an epilepsy patient it means minimizing the noise level and providing a dim light environment.

Limit Screen Time: Lights or screens that are flashing can cause seizures in a few individuals.

Prepare the emergency:

Seizure Action Plan: Prepare for it an action procedure that will particularly outline what should be done when a seizure occurs.

It is very important that the family and caregivers taking care of the person are all informed about this plan.

Medical Alert: Discuss with the patient the use of a medical alert or device that can provide information in the event of a seizure to others.

Resources within Communities:

Support Groups: Shared experiences, support groups that are specifically designed for epilepsy.

Professional Counselling: Advice from healthcare professionals will guide one in making the best decisions and create a good number of supportive ideas individualized within a given setting.

Neurology

Carbamazepine (Tegretol)

Stabilizes hyperexcitable neuronal membranes due to sodium channel blockade.

Often first-line treatment.

Reassess for dizziness, drowsiness, and possible blood dyscrasias.

Lamotrigine (Lamictal)

Blocks voltage-sensitive sodium channels and decreases glutamate release.

Generally tolerated and helpful for both focal and generalized seizure activity.

Risk of skin rashes including Stevens-Johnson syndrome; especially concerning with rapid titration.

Levetiracetam (Keppra)

Binds to SV2A protein that modulates synaptic neurotransmitter release.

Favorable side-effect profile. May cause behavior disturbances in some patients.

Valproate (Depakote)

Increases GABA levels and inhibits sodium channels.

Efficacy across a wide spectrum

Monitor liver function, platelet count.

Teratogenicity is possible when used during pregnancy.

Topiramate (Topamax)

Blocks sodium channels, enhances GABA activity, antagonizes glutamate receptors.

Can cause cognitive, weight loss and metabolic acidosis side-effects.

Phenytoin (Dilantin)

It may stabilize neuronal membranes via sodium channel blockade.

Long history of use but not favored much because of side effects, such as gum hypertrophy and drug interactions.

Neurology

Drug-Resistant Epilepsy: Usually, surgery is an option when a patient fails to respond to two or more medications designed to control seizures.

Localized Epileptogenic Zone: Seizures from a defined, localized part of the brain are more likely to succeed with surgery.

Types of Surgery
Resective Surgery: This operation involves the removal of some of the brain tissue where seizures arise.
Common practices are:
Temporal Lobectomy: A portion of the temporal lobe is removed to treat patients suffering from temporal lobe epilepsy.
Extratemporal Resection: External fields beyond the temporal lobe must be removed in patients subjected to focal epilepsies of different forms.

Neurology

Phase of Prevention and Evaluation of Risks (Pre-convulsive):

Activation Triggers:

Stress, lack of sleep and other stimuli capable of triggering seizure.

Education: Instructing the patient and/or the family on the types of seizures, recognition of their characteristics and probable outcome. Lifestyle Modification: Reported good health practice often through personal care, observing simple hygiene practices, maintaining proper sleeping habits, good management of stress and avoiding situations that may cause one to have a seizure.

Encourage that patient to use their AED as prescribed to avoid the seizure.

Care: When an attack begins, the person is given shielding interventions that include safeguarding them and, if possible, placing the person on their side.

Recovery and Evaluation phase:

Observation: For signs that indicate confusion, fatigue or amnesia which manifests itself after the seizure has taken place.

Evaluation: The need for further research will be underlined while speaking about triggering elements and the assessment will examine the outcomes of the seizure for the patient.

Communication: The Scenario describes what happened in the patient during the seizure and how the treatment or management strategies could have been different.

Long-Term Management:

Medications: Modifying or optimizing the strategies to increase AED duration due to the characteristics, distribution, and other consequences of seizures.

Follow-Up: To properly track the seizure status, a neurologist must get systematic appointments to follow up on how well the medicine works.

Psychological/psychosocial: Assistance in taking advantage of counselling, support group, and psychotherapy on the psychosocial or social aspect in relates to the condition.

Advanced Therapies

Evaluation: Consider VNS along with RNS, as well as exploring other surgical options as well.

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