DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency defined:  

>10% 

Tablets and oral solution 

Dizziness (16-53%) 

Diplopia (6-16%) 

Blurred vision (2-16%) 

Nausea (7-17%) 

Vomiting (6-16%) 

Fatigue (7-15%) 

Ataxia (11-14%) 

Nystagmus (2-10%)  

IV 

Fatigue (20-63%) 

Somnolence (26-34%) 

Headache (4-16%) 

Diplopia (4-20%) 

Nausea (14-24%) 

Dry mouth (6-12%) 

Vomiting (4-12%) 

Fatigue (12-18%) 

Chest pain (3-12%) 

1-10% 

Tablets and oral solution  

Nystagmus (2-10%) 

Memory impairment (1-6%) 

Balance disorder (1-6%) 

Diarrhea (3-5%) 

Gait disturbance (<1-4%) 

Asthenia (1-3%) 

Vertigo (1-4%) 

Pruritus (2-3%) 

Depression (2%)  

IV  

Oral paresthesia (4-8%) 

Oral hypoesthesia (5-8%) 

Diarrhea (4-8%) 

Paresthesia (4-8%) 

Gait disturbance (2-8%) 

Hyperhidrosis (2-8%) 

Tremor (4-6%) 

Abnormal coordination (3-6%) 

Pruritus (4-6%) 

 

 

Pregnancy consideration: The drug may cross the placenta and can be detected in the serum of the newborn. 

Pregnancy category: C 

Lactation: The drug is known to be excreted in the human breast milk  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: No data is available for the drug under this category. 

Patient information leaflet 

Generic Name: Lacosamide 

Pronounced: (la koe’ sa mide)  

Why do we use lacosamide? 

Lacosamide is used to treat partial onset seizures and works by decreasing the abnormal electrical activity in the brain.