Enuresis

Updated: August 2, 2024

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Background

Enuresis comes from the Greek verb ‘enourein’, which translates into ‘void urine’, and it describes involuntary urination which may occur at any time of the day, although it is more commonly used when referring to bed wetting at night. There are two types of enuresis; such as primary and secondary. Primary enuresis involves a child who has never slept through the night without wetting the bed while secondary enuresis is a child or an adult who used to sleep through the night but began wetting the bed again.  

The International Children’s Continence Society (ICCS) defines enuresis as wetting only at night. It is believed that the causes of PE and SE are one and the same. It has been known to cause emotional problems among children and their families. These children end up being punished and they are even likely to be emotionally and physically abused. Research reveals that these children have high probabilities of developing embarrassment, anxiety, and low self-esteem, which impacts their self-image, interpersonal relationships, well-being, and academic outcomes. 

Epidemiology

It is estimated that 20% of children are enuretic at the age of 5 with prevalence of the condition rising to 5 to 10% at age 7. Enuresis in adults is estimated to affect 2% of the general population. The condition is more common in boys than in girls. 

Anatomy

Pathophysiology

Studying the mechanisms of enuresis it was established that patients suffering from this disease have a decreased level of nocturnal ADH. This deficiency led to excessive formation of urine at night and hence frequent urination. From this perspective, drugs like desmopressin that mimics the action of ADH are often used in the treatment of the condition. Other theories on the causation of enuresis propose that the disease is caused by reduced bladder capacity or the ability to wake from sleep. 

Etiology

Most enuresis patients present no obvious causes for their conditions and are deemed idiopathic. However, some of the key risk factors in children include constipation and neurodevelopmental conditions. Other possible factors for consideration include sleep arousal disorders, delayed bladder maturation, small bladder capacity and decreased release of vasopressin. There are also differential diagnoses that can be related to enuresis such as medical conditions or use of certain medications. 

The following are considered as factors which predispose a child to enuresis, stress, low standard of living, parental separation or divorce, arrival of a newborn baby in the family and past history of enuresis in the family. It has a hereditary factor attached to it, where the chances of bedwetting are 44% if one parent was a bedwetter, and 77% if both parents were. While no exact point mutation has been isolated, researchers have found potential significant gene regions on 8, 12, 13 and 16 chromosomes. Another reason that leads to enuresis is constipation, as it can put pressure on the bladder. 

Genetics

Prognostic Factors

Enuresis can cause severe rashes over the perineal, genital, and lower abdominal skin, including breakdown of the skin in severe cases and very rarely infection. In case of relapse, the patient must continue with the previous treatments, which is one of the impacts of the treatment. It is important to treat enuresis primarily because it affects the self-esteem of the child and might lead to psychological/behavioral problems. Treatment results in an increase in self-esteem at a rate like that of non-enuretic children at the end of six months. 

Originally, for enuresis it is seen that there is an estimated spontaneous cure rate of approximately 15% per year. However, children who wet the bed every night cannot easily be treated and many of them experience the condition during their adolescence. If enuresis is the only symptom, the patient can be treated by behavioral interventions, which include bedwetting alarms, or pharmacological interventions that include desmopressin and imipramine 

Clinical History

Age group 

Primary Enuresis: Most frequent in children ranging from 5 to 7 years of age and occasionally in young adolescents. 

Secondary Enuresis: It happens in older children or adolescent who was previously urinary incontinence free. 

Physical Examination

In performing the physical examination of a child with enuresis, it is recommended that a thorough examination of the kid be carried out to determine the presence of any disease that may be causing the condition. This is done by evaluating the child’s overall progress, observing the abdomen for signs of distended bladder or constipation and examining the genitourinary area for any sign of statues like phimosis, labial fusion or rash or signs of irritation.

A basic neurological exam should be performed to ensure that there are no spinal cord abnormalities, and the lumbosacral spine should be examined for signs of abnormalities such as sacral dimples or tufts of hair. Looking for signs of enlarged tonsils, which may indicate obstructive sleep apnea, or some signs of dehydration or an underlying skin condition. 

Age group

Associated comorbidity

  • Constipation 
  • Neurodevelopmental Disorders 
  • Psychological Stressors 
  • Family History 

Associated activity

Acuity of presentation

  • Primary Enuresis: Generally, it is a non-acute, long standing and more often the symptoms of the condition are there without prior dryness. 
  • Secondary Enuresis: May be more prominent after using it for a short time after a dry spell, which may be due to psychological stress, new medical condition, or new medications. 

Differential Diagnoses

  • Constipation 
  • Urinary Tract Infections (UTIs) 
  • Diabetes Mellitus 
  • Diabetes Insipidus 
  • Obstructive Sleep Apnea (OSA) 

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

Behavioural Interventions 

  • Bedwetting Alarms: These devices senses humidity and helps to wake the child because it is possible to wake up when the bladder is full. They are successful in about two-thirds of children and assist in the process of training a child to learn to recognize bladder signals. 
  • Bladder Training: Strategies like timetabled micturition and step by step progression of intervals between washroom visits can be effective in attaining bladder control. 

Pharmacological Treatments 

  • Desmopressin: An ADH analog that decreases the urinary output at night, useful in minimizing episodes of nocturnal enuresis among children. It is commonly applied as an emergency short-term intervention or when other forms of intervention fail.
  • Imipramine: A drug that belongs to tricyclic antidepressants and that can be used to decrease bedwetting due to its ability to extend the bladder’s capacity and the ways it regulates its function. Its use is rare due to side effects that are associated with it. 
  • Anticholinergics: Pharmaceuticals such as oxybutynin can be effective for some patients suffering from overactive bladder signs. 

Addressing Underlying Medical Conditions 

  • Treat Constipation: In cases where constipation is the cause of enuresis it can be helpful to address constipation with dietary changes, increased water intake, or the use of laxatives. 
  • Manage Diabetes Mellitus or Diabetes Insipidus: These conditions can be well managed to ensure that polyuria and enuresis are minimized. 
  • Psychological and Emotional Support: Encouraging family participation and incorporating them in the management of the patient will assist in minimizing the effects of emotion and enhancing compliance with treatment plans. 

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

use-of-a-non-pharmacological-approach-for-treating-enuresis

  • Fluid Management: Fluid intake should also be limited in the evening and refraining from drinking any fluids containing caffeine or other diuretics during the evening hours will also assist in limiting the amount of urine produced at night. Bed wetting can be eradicated by ensuring that the child begins using the bathroom before going to bed, practicing on the right bedtime routine. 
  • Psychological and Emotional Support: In children that are likely to have other emotions or psychological problems, other treatments that can be administered include therapy or counseling to help identify the cause of enuresis like anxiety or tension at home. This is done to provide support to the child and cope up with the emotional stress that is likely to come along the process of treatment. 
  • Lifestyle Modifications: This may involve washing, using the toilet before going to bed or any other pattern that the individual can follow to reduce the chances of an accident occurring. Inability to produce urine during the night is due to inadequate conditioning of the bladder throughout the day by production of adequate amounts of urine. 

Role of TCAs, Antidepressants

Imipramine (Tofranil): It aids in the enhancement of urine reservoir capacity through decreasing the contractions of the bladder and at the same time there is increased resistance at the outlet of the bladder. The mechanism of its action is based on the interference with the reuptake of norepinephrine and serotonin at presynaptic neuron. 

Role of Antispasmodic Agents, Urinary

Oxybutynin (Ditropan XL, Gelnique, Oxytrol): It is prescribed for children who might have the decreased functional bladder capacity either during the daytime or at night. It can be helpful for controlling the frequency, urgency, and incontinence during the day, and bedwetting during the night. It is also important to understand that oxybutynin is not recommended for use in children below twelve years of age. 

Tolterodine (Detrol): It is a potent and selective competitive muscarinic receptor antagonist that selectively acts on the urinary bladder and does not affect the salivary glands. It is used for urinary urgency, frequency during the daytime, sudden urge to urinate, and other complications such as urinary incontinence and bed wetting during the night. It is effective for those with decreased functional bladder capacity during the daytime or at night. 

Flavoxate (Urispas): It is used to offer therapeutic relief for the condition in patients with incontinence. It has direct anticholinergic activity and affects the smooth muscles by relieving the muscular contractions in the urinary system. 

use-of-intervention-with-a-procedure-in-treating-enuresis

  • Urodynamic Studies: Urodynamic testing includes several procedures that assess the ability of the bladder and urethra to function properly. These tests assess the capacity of the bladder to contain urine as well as expel it and will aid in identifying bladder problems in enuretic children. This procedure is particularly helpful in children with complicated enuresis, specifically if the child suffers from diurnal urinary incontinence or if the child may have neurogenic bladder, or if prior treatments have not proved effective. 
  • Cystoscopy: It involves using endoscopy where a needle-sized telescope (cystoscope) is passed through the urethra to get a view of the bladder lining. Even though cystoscopy is not usually carried out to investigate enuresis, it may be employed if there is an assumption of anatomical lesion in the bladder or urethra that can cause bed wetting. 
  • Surgery for Underlying Conditions: Surgical procedures are often required in the case of ectopic ureter, ureterocele, or any severely narrowing urethra causing bladder outlet obstruction. These conditions may lead to symptoms that present like enuresis. 

use-of-phases-in-managing-enuresis

  • Assessment Phase: Assess the child’s medical history, family history, and psychosocial history to know if there is any medical condition existing, stressors, or any past intakes of drugs or treatment. Conduct a general clinical assessment or physical examination and sometimes do tests and investigations such as urine analysis for the presence of other illnesses causing enuresis. 
  • Initial Management Phase: Apply measures like using alarm systems when wetting the bed and training to hold urine long enough. These treatments are usually considered first-line therapies and these goals are achieved through conditioning and training. Educate on aspects such as how to decrease intake of fluids in the evening and need for a proper sleep schedule. 
  • Secondary Management Phase: If behavioural interventions and lifestyle modifications have been ineffective, several medications may be employed depending on the type and severity of OAB and the response to earlier treatment regimens, including desmopressin, imipramine, and oxybutynin. If psychological factors or stress are the cause of enuresis, then counselling or therapy may be required. 
  • Follow-Up and Monitoring Phase: Ensure regular follow up appointments with the child and review of interventions for progress, efficacy and need for change. If there is no improvement, consult the diagnosis and treatment course again because other factors should be taken into consideration or other treatment options should be considered. 
  • Maintenance and Prevention Phase: Supportive care and counselling should be maintained for the child as well as the family so that they can adequately cope with the illness. 

Medication

 
 

nortriptyline 

Indicated for Nocturnal enuresis:


6-7 years:10mg orally whenever necessary
8-11 years: 10-20mg orally whenever necessary
>11 years: 25-30mg orally whenever necessary



imipramine/chlordiazepoxide 

Take 25 mg daily initially
It is advisable to take this medication approximately an hour before going to bed



 

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Enuresis

Updated : August 2, 2024

Mail Whatsapp PDF Image



Enuresis comes from the Greek verb ‘enourein’, which translates into ‘void urine’, and it describes involuntary urination which may occur at any time of the day, although it is more commonly used when referring to bed wetting at night. There are two types of enuresis; such as primary and secondary. Primary enuresis involves a child who has never slept through the night without wetting the bed while secondary enuresis is a child or an adult who used to sleep through the night but began wetting the bed again.  

The International Children’s Continence Society (ICCS) defines enuresis as wetting only at night. It is believed that the causes of PE and SE are one and the same. It has been known to cause emotional problems among children and their families. These children end up being punished and they are even likely to be emotionally and physically abused. Research reveals that these children have high probabilities of developing embarrassment, anxiety, and low self-esteem, which impacts their self-image, interpersonal relationships, well-being, and academic outcomes. 

It is estimated that 20% of children are enuretic at the age of 5 with prevalence of the condition rising to 5 to 10% at age 7. Enuresis in adults is estimated to affect 2% of the general population. The condition is more common in boys than in girls. 

Studying the mechanisms of enuresis it was established that patients suffering from this disease have a decreased level of nocturnal ADH. This deficiency led to excessive formation of urine at night and hence frequent urination. From this perspective, drugs like desmopressin that mimics the action of ADH are often used in the treatment of the condition. Other theories on the causation of enuresis propose that the disease is caused by reduced bladder capacity or the ability to wake from sleep. 

Most enuresis patients present no obvious causes for their conditions and are deemed idiopathic. However, some of the key risk factors in children include constipation and neurodevelopmental conditions. Other possible factors for consideration include sleep arousal disorders, delayed bladder maturation, small bladder capacity and decreased release of vasopressin. There are also differential diagnoses that can be related to enuresis such as medical conditions or use of certain medications. 

The following are considered as factors which predispose a child to enuresis, stress, low standard of living, parental separation or divorce, arrival of a newborn baby in the family and past history of enuresis in the family. It has a hereditary factor attached to it, where the chances of bedwetting are 44% if one parent was a bedwetter, and 77% if both parents were. While no exact point mutation has been isolated, researchers have found potential significant gene regions on 8, 12, 13 and 16 chromosomes. Another reason that leads to enuresis is constipation, as it can put pressure on the bladder. 

Enuresis can cause severe rashes over the perineal, genital, and lower abdominal skin, including breakdown of the skin in severe cases and very rarely infection. In case of relapse, the patient must continue with the previous treatments, which is one of the impacts of the treatment. It is important to treat enuresis primarily because it affects the self-esteem of the child and might lead to psychological/behavioral problems. Treatment results in an increase in self-esteem at a rate like that of non-enuretic children at the end of six months. 

Originally, for enuresis it is seen that there is an estimated spontaneous cure rate of approximately 15% per year. However, children who wet the bed every night cannot easily be treated and many of them experience the condition during their adolescence. If enuresis is the only symptom, the patient can be treated by behavioral interventions, which include bedwetting alarms, or pharmacological interventions that include desmopressin and imipramine 

Age group 

Primary Enuresis: Most frequent in children ranging from 5 to 7 years of age and occasionally in young adolescents. 

Secondary Enuresis: It happens in older children or adolescent who was previously urinary incontinence free. 

In performing the physical examination of a child with enuresis, it is recommended that a thorough examination of the kid be carried out to determine the presence of any disease that may be causing the condition. This is done by evaluating the child’s overall progress, observing the abdomen for signs of distended bladder or constipation and examining the genitourinary area for any sign of statues like phimosis, labial fusion or rash or signs of irritation.

A basic neurological exam should be performed to ensure that there are no spinal cord abnormalities, and the lumbosacral spine should be examined for signs of abnormalities such as sacral dimples or tufts of hair. Looking for signs of enlarged tonsils, which may indicate obstructive sleep apnea, or some signs of dehydration or an underlying skin condition. 

  • Constipation 
  • Neurodevelopmental Disorders 
  • Psychological Stressors 
  • Family History 
  • Primary Enuresis: Generally, it is a non-acute, long standing and more often the symptoms of the condition are there without prior dryness. 
  • Secondary Enuresis: May be more prominent after using it for a short time after a dry spell, which may be due to psychological stress, new medical condition, or new medications. 
  • Constipation 
  • Urinary Tract Infections (UTIs) 
  • Diabetes Mellitus 
  • Diabetes Insipidus 
  • Obstructive Sleep Apnea (OSA) 

Behavioural Interventions 

  • Bedwetting Alarms: These devices senses humidity and helps to wake the child because it is possible to wake up when the bladder is full. They are successful in about two-thirds of children and assist in the process of training a child to learn to recognize bladder signals. 
  • Bladder Training: Strategies like timetabled micturition and step by step progression of intervals between washroom visits can be effective in attaining bladder control. 

Pharmacological Treatments 

  • Desmopressin: An ADH analog that decreases the urinary output at night, useful in minimizing episodes of nocturnal enuresis among children. It is commonly applied as an emergency short-term intervention or when other forms of intervention fail.
  • Imipramine: A drug that belongs to tricyclic antidepressants and that can be used to decrease bedwetting due to its ability to extend the bladder’s capacity and the ways it regulates its function. Its use is rare due to side effects that are associated with it. 
  • Anticholinergics: Pharmaceuticals such as oxybutynin can be effective for some patients suffering from overactive bladder signs. 

Addressing Underlying Medical Conditions 

  • Treat Constipation: In cases where constipation is the cause of enuresis it can be helpful to address constipation with dietary changes, increased water intake, or the use of laxatives. 
  • Manage Diabetes Mellitus or Diabetes Insipidus: These conditions can be well managed to ensure that polyuria and enuresis are minimized. 
  • Psychological and Emotional Support: Encouraging family participation and incorporating them in the management of the patient will assist in minimizing the effects of emotion and enhancing compliance with treatment plans. 

Allergy and Immunology

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Cardiology, Echocardiography

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Other Clinical

Non-Clinical

  • Fluid Management: Fluid intake should also be limited in the evening and refraining from drinking any fluids containing caffeine or other diuretics during the evening hours will also assist in limiting the amount of urine produced at night. Bed wetting can be eradicated by ensuring that the child begins using the bathroom before going to bed, practicing on the right bedtime routine. 
  • Psychological and Emotional Support: In children that are likely to have other emotions or psychological problems, other treatments that can be administered include therapy or counseling to help identify the cause of enuresis like anxiety or tension at home. This is done to provide support to the child and cope up with the emotional stress that is likely to come along the process of treatment. 
  • Lifestyle Modifications: This may involve washing, using the toilet before going to bed or any other pattern that the individual can follow to reduce the chances of an accident occurring. Inability to produce urine during the night is due to inadequate conditioning of the bladder throughout the day by production of adequate amounts of urine. 

Pediatrics, General

Surgery, General

Desmopressin: Desmopressin acetate is a synthetic hormone that mimics antidiuretic hormone (ADH) which is used to reduce the rate of urine production during the night. Studies showed that some children with bedwetting have comparatively smaller concentration of ADH at night than than those who are not involved in bedwetting and therefore approved of desmopressin. However, not all children with enuresis have low levels of ADH or high nighttime urine output and some of them do not go in to remission following desmopressin therapy.  

Moreover, not all who respond over time have abnormally low ADH levels or high free water clearance at night prior to taking the medication. Oral desmopressin is available in tablets and in dissolvable film form, and the nasal spray definitively acts by increasing the permeability of the collecting ducts of the kidney, thereby aiding water reabsorption. Because of potential complications related to sever hyponatremia the nasal spray formulation is no longer used for primary enuresis treatment. 

Pediatrics, General

Surgery, General

Imipramine (Tofranil): It aids in the enhancement of urine reservoir capacity through decreasing the contractions of the bladder and at the same time there is increased resistance at the outlet of the bladder. The mechanism of its action is based on the interference with the reuptake of norepinephrine and serotonin at presynaptic neuron. 

Pediatrics, General

Surgery, General

Oxybutynin (Ditropan XL, Gelnique, Oxytrol): It is prescribed for children who might have the decreased functional bladder capacity either during the daytime or at night. It can be helpful for controlling the frequency, urgency, and incontinence during the day, and bedwetting during the night. It is also important to understand that oxybutynin is not recommended for use in children below twelve years of age. 

Tolterodine (Detrol): It is a potent and selective competitive muscarinic receptor antagonist that selectively acts on the urinary bladder and does not affect the salivary glands. It is used for urinary urgency, frequency during the daytime, sudden urge to urinate, and other complications such as urinary incontinence and bed wetting during the night. It is effective for those with decreased functional bladder capacity during the daytime or at night. 

Flavoxate (Urispas): It is used to offer therapeutic relief for the condition in patients with incontinence. It has direct anticholinergic activity and affects the smooth muscles by relieving the muscular contractions in the urinary system. 

Allergy and Immunology

Anesthesiology

Cardiology, Echocardiography

Cardiology, Electrophysiology

Cardiology, General

Cardiology, Interventional

Cardiology, Nuclear

Critical Care/Intensive Care

Dermatology, General

Dermatology, Cosmetic

Diabetes

Diabetes Educator

Emergency Medicine

Endocrinology, Metabolism

Endocrinology, Reproductive/Infertility

Family Medicine

Gastroenterology

General Practice

Genomic Medicine

Geriatrics

Hematology

Hepatology

HIV/AIDS

Hospice/Palliative Medicine

Hospital Medicine

Infectious Disease

Internal Medicine

Neonatal/Perinatal Medicine

Nephrology

Neurology

Neurosurgery

Nuclear Medicine

Nutrition

OB/GYN and Women\'s Health

Oncology, Hematology/Oncology

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Oncology, Other

Oncology, Radiation

Ophthalmology

Orthopaedic Surgery

Otolaryngology

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Pathology

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Pediatrics, Cardiology

Pediatrics, General

Pediatrics, Oncology

Physical Medicine and Rehabilitation

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Preventative Medicine

Psychiatry/Mental Health

Public/Community Health

Pulmonary Medicine

Radiology

Radiology, Interventional

Rheumatology

Surgery, Cardiothoracic

Surgery, General

Surgery, Oral and Maxillofacial

Surgery, Other

Surgery, Surgical Oncology

Surgery, Vascular

Transplantation

Urology

Vascular Medicine

Other Clinical

Non-Clinical

  • Urodynamic Studies: Urodynamic testing includes several procedures that assess the ability of the bladder and urethra to function properly. These tests assess the capacity of the bladder to contain urine as well as expel it and will aid in identifying bladder problems in enuretic children. This procedure is particularly helpful in children with complicated enuresis, specifically if the child suffers from diurnal urinary incontinence or if the child may have neurogenic bladder, or if prior treatments have not proved effective. 
  • Cystoscopy: It involves using endoscopy where a needle-sized telescope (cystoscope) is passed through the urethra to get a view of the bladder lining. Even though cystoscopy is not usually carried out to investigate enuresis, it may be employed if there is an assumption of anatomical lesion in the bladder or urethra that can cause bed wetting. 
  • Surgery for Underlying Conditions: Surgical procedures are often required in the case of ectopic ureter, ureterocele, or any severely narrowing urethra causing bladder outlet obstruction. These conditions may lead to symptoms that present like enuresis. 

  • Assessment Phase: Assess the child’s medical history, family history, and psychosocial history to know if there is any medical condition existing, stressors, or any past intakes of drugs or treatment. Conduct a general clinical assessment or physical examination and sometimes do tests and investigations such as urine analysis for the presence of other illnesses causing enuresis. 
  • Initial Management Phase: Apply measures like using alarm systems when wetting the bed and training to hold urine long enough. These treatments are usually considered first-line therapies and these goals are achieved through conditioning and training. Educate on aspects such as how to decrease intake of fluids in the evening and need for a proper sleep schedule. 
  • Secondary Management Phase: If behavioural interventions and lifestyle modifications have been ineffective, several medications may be employed depending on the type and severity of OAB and the response to earlier treatment regimens, including desmopressin, imipramine, and oxybutynin. If psychological factors or stress are the cause of enuresis, then counselling or therapy may be required. 
  • Follow-Up and Monitoring Phase: Ensure regular follow up appointments with the child and review of interventions for progress, efficacy and need for change. If there is no improvement, consult the diagnosis and treatment course again because other factors should be taken into consideration or other treatment options should be considered. 
  • Maintenance and Prevention Phase: Supportive care and counselling should be maintained for the child as well as the family so that they can adequately cope with the illness. 

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