One Cup of Coffee a Day Keeps AF Away? Insights from the DECAF Trial
November 10, 2025
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Brand Name :
Cafcit, ReCharge, Vivarin, NoDoz
Synonyms :
Caffeine
Class :
Respiratory Stimulants, Phosphodiesterase Enzyme Inhibitors
Brand Name :
Cafcit, ReCharge, Vivarin, NoDoz
Synonyms :
Caffeine
Class :
Respiratory Stimulants, Phosphodiesterase Enzyme Inhibitors
Dosage Forms & StrengthsÂ
Injectable solutionÂ
20mg/mlÂ
Oral solutionÂ
20mg/mlÂ
TabletsÂ
200 mgÂ
CapsulesÂ
200 mgÂ
LozengesÂ
75 mgÂ
100-200
mg
Tablet
Orally 
3 times a day
Dosage Forms & StrengthsÂ
Injectable solutionÂ
10mg/mlÂ
Oral solutionÂ
10mg/mlÂ
TabletsÂ
200 mgÂ
CapsulesÂ
200 mgÂ
LozengesÂ
75 mgÂ
100-200
mg/day
Tablet
Orally 
3 times a day
<12years: not recommended
>12 years: 100-200mg orally thrice or four times a day
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of non-opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of non-opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of non-opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of non-opioid drugs
CNS stimulants: they may increase the CNS stimulant effect of non-opioid drugs
the effects of caffeine may be enhanced with linezolid such as risk of hypertension
the effects of caffeine may be enhanced with procarbazine due to synergistic action
the effects of caffeine may be enhanced with isocarboxazid when co-administered
the effects of caffeine may be enhanced with selegiline transdermal when coadministered
the effects of fezolinetant may be increased with caffeine by altering CYP1A2 metabolism
the effects of dipyridamole will be reduced with caffeine due to antagonism
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
may decrease the therapeutic effect when combined with iobenguane radiopharmaceutical products
CNS depressants increase the effect of orphenadrine
caffeine and its products increase the toxicity of doxofylline
Combining tegafur with caffeine can reduce tegafur’s metabolism
When domeperidone and caffeine is used together, this leads to reduction in the domeperidone’s metabolism
When caffeine is used together with somatotropin, this leads to a rise in caffeine’s metabolism
toxicity of bupropion may be increased with caffeine
the effects of givosiran may be increased with caffeine by altering CYP1A2 metabolism
the effects of regadenoson will be reduced with caffeine due to antagonism
sedative effects will be decreased with caffeine and increased with codeine
administration of caffeine with dopamine reduces sedation
the effects of either of the drug may be effected when amantadine and caffeine is co-administered
caffeine: it may decrease the metabolism of bamifylline
when both drugs are combined, there may be a reduced excretion rate of topotecan   
norfloxacin increases the concentration of caffeine in serum
may increase the adverse effect of caffeine and caffeine containing products
they decrease the effect of each other by pharmacodynamic antagonism
they decrease the effect of each other by pharmacodynamic antagonism
they decrease the effect of each other by pharmacodynamic antagonism
they decrease the effect of each other by pharmacodynamic antagonism
they decrease the effect of each other by pharmacodynamic antagonism
metyrosine: they may increase the sedative effect of CNS stimulants
pegvisomant: they may increase the sedative effect of CNS stimulants
ramosetron: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
opioid drugs: they may increase the sedative effect of CNS stimulants
carbimazole may reduce the excretion rate of caffeine, potentially leading to a higher serum level
the rate of metabolism of caffeine may be reduced
etoricoxib: it may decrease the excretion rate of caffeine
The therapeutic effect of adenosine may be reduced by the presence of caffeine and caffeine Containing Products
Frequency Not DefinedÂ
TachycardiaÂ
NervousnessÂ
NauseaÂ
VomitingÂ
DiarrhoeaÂ
RestlessnessÂ
TremorÂ
InsomniaÂ
IrritabilityÂ
TinnitusÂ
DiuresisÂ
Black box warning:Â
NoneÂ
Contraindications/caution:Â
Contraindications:Â
Cautions:Â
Pregnancy Warnings:Â
Pregnancy category: CÂ
Lactation: It enters human breast milkÂ
Pregnancy categories:Â
Pharmacology: Caffeine blocks adenosine receptors to enhance neuronal activity which releases dopamine and norepinephrine for stimulation.Â
Pharmacodynamics: The antagonizing adenosine receptors to enhance neurotransmitter release and neuronal firing that blocks inhibitory effects.Â
Pharmacokinetic:Â
Absorption:Â
It has peak plasma time up to 30 to 120 minutes.Â
Distribution:Â
It shows protein bound of 17% to 96%.Â
Metabolism:Â
It is metabolized through CYP1A2 pathway.Â
Excretion and elimination:Â
It is excreted through urinary route.Â
Administration:Â
It is taken orally in form of tablet and capsule.Â
Patient information leaflet:Â
Generic name: caffeineÂ
Why do we use caffeine? Â
Caffeine is indicated in treatment of apnea to reduce the frequency of apneic episodes in premature infants.Â
It is used to relieve tension headaches and migraines in adults.Â
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