Gonococcal Infection

Updated: July 21, 2022

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

cefotaxime

0.5 g IM given once for urethritis or cervicitis
0.5 g IM given once for Rectal gonorrhea (females)
1 g IM given once for Rectal gonorrhea (males)

minocycline

100 mg orally every 12hrs for five days for urethritis in men
200 mg initially followed by 100 mg orally every 12hrs for at least four days for infections other than urethritis and anorectal infections in men

ceftriaxone

Indicated to uncomplicated cervical, urethral and rectal gonorrhea due to Neisseria gonorrhoeae and pharyngeal gonorrhea
250 mg IM as a single dose
500 mg IM as a single dose for less than 150 kg
1 g IM as a single dose for at least 150 kg

amoxicillin

Mild/moderate/severe:

as a single dose

pivampicillin

Indicated for Gonococcal urethritis
1.5 gm orally one time along with 1 gm of probenecid Bacterial infections
500 mg orally two times a day
In severe infection conditions, the dose may be doubled

ceftizoxime

The usual dose 1 g IM or IV thrice a day

Dose Adjustments

Renal Dose Adjustment
In case of renal insufficiency, the usual dose of ceftizoxime depends on the CrCl. If the CrCl is below 5 mL/min, then 0.25-0.5 g a day or 0.5-1 g via IV or IM in 2 days after undergoing dialysis. Loading dose is standard in renal insufficiency, which is 0.5-1 g. 0.25 -1g twice a day if CrCl falls between 5 and 49 mL/min and 0.5 – 1.5 g thrice a day if CrCl is between 50 and 79 mL/min

bacampicillin

Mild/Moderate: A dose of 1.6 g is given orally with 1 g of probenecid as a single dose

Moreover, in the US the drug bacampicillin is no longer used and marketed

mezlocillin

Mild/Moderate: A dose of 1-2 g IV or IM given in one dose and probenecid 1 g given orally at the time of dosing or before 30 minutes

piperacillin

Mild/moderate: A dose of 2g IM given per day once

Future Trends