Iatrogenic Cushing Syndrome is causes due to prolonged administration or overdose of glucocorticoid drug. It is a condition which develops because of medical interventions.
Glucocorticoids are widely suggested by physicians to treat various inflammatory and autoimmune conditions. This suppress the immune system in cases of organ transplantation.
This syndrome arises due to an excess level of cortisol. It is a steroid hormone which is derived from the adrenal glands.
Epidemiology
The Prevalence is depending on population, duration, and dose of glucocorticoid therapy.
The high risk for patients is noticed with certain medical conditions due to prolonged use. For Short-term use the low-dose therapy is less likely to develop the syndrome.
The high-level dose of glucocorticoids and extended durations of treatment develops the risk of syndrome.
Anatomy
Pathophysiology
Prednisone and dexamethasone bind to glucocorticoid receptors in cells.
Glucocorticoids initiate cellular responses then modulate into gene expression.
Exogenous glucocorticoids gives negative feedback on HPA axis, so they reduces CHR and ATH release.
Etiology
The risk of developing Iatrogenic Cushing Syndrome is often dose dependent.
It is prescribed by physicians in conditions like autoimmune diseases, inflammatory disorders, asthma, and organ transplantation.
Genetics
Prognostic Factors
An early identification and timely intervention treatment can help to improve prognosis.
The symptoms reversible upon discontinuation and tapering of glucocorticoid therapy.
The reversibility based on duration of exposure and susceptibility of individual.
Clinical History
Clinical History:
In children and adolescents if physician suggested glucocorticoids drugs, then it can lead to syndrome.
Pediatric patients are more vulnerable to glucocorticoid therapy effects.
Physical Examination
Cardiovascular Examination
Musculoskeletal Examination
Joint Examination
Neurological and Psychological Assessment
Age group
Associated comorbidity
Prolonged exposure to high levels of glucocorticoids can lead to decreased bone mineral density and an increased risk of osteoporosis. Iatrogenic Cushing Syndrome is associated with an increased risk of cardiovascular complications, including hypertension, atherosclerosis, and an elevated risk of cardiovascular events such as heart attacks and strokes.
Glucocorticoids can induce metabolic changes, including insulin resistance, impaired glucose tolerance, and an increased risk of developing diabetes mellitus.One of the characteristic features of Cushing Syndrome is central obesity, with an accumulation of fat around the abdomen and face.
This can contribute to weight gain and an increased risk of metabolic syndrome.Glucocorticoids can lead to muscle wasting and weakness, which may contribute to decreased physical function and exercise intolerance.
Associated activity
Acuity of presentation
In many cases symptoms occurs gradual development over time with prolonged glucocorticoid use.
Initial body composition shows changes like weight gain and fat redistribution.
The systemic effects of glucocorticoids shows endocrine disturbances and menstrual irregularities.
Differential Diagnoses
Primary Adrenal Disease:
Exogenous Glucocorticoid Use
Pseudo-Cushing Syndrome
Laboratory Studies
Imaging Studies
Procedures
Histologic Findings
Staging
Treatment Paradigm
Adrenal function monitoring importance is essential during and after tapering process.
Psychological support is beneficial for mood changes or emotional distress.
Patients should follow a healthy diet and lifestyle can shows metabolic consequences of glucocorticoid therapy.
The diagnosis phase involves the initial identification of the signs and symptoms of Cushing Syndrome. This includes central obesity, moon face, muscle weakness, and psychological changes.
On regular basis monitor adrenal function during the tapering process to assess recovery.
Schedule regular follow-up to monitor the patient’s progress.
Iatrogenic Cushing Syndrome is causes due to prolonged administration or overdose of glucocorticoid drug. It is a condition which develops because of medical interventions.
Glucocorticoids are widely suggested by physicians to treat various inflammatory and autoimmune conditions. This suppress the immune system in cases of organ transplantation.
This syndrome arises due to an excess level of cortisol. It is a steroid hormone which is derived from the adrenal glands.
The Prevalence is depending on population, duration, and dose of glucocorticoid therapy.
The high risk for patients is noticed with certain medical conditions due to prolonged use. For Short-term use the low-dose therapy is less likely to develop the syndrome.
The high-level dose of glucocorticoids and extended durations of treatment develops the risk of syndrome.
Prednisone and dexamethasone bind to glucocorticoid receptors in cells.
Glucocorticoids initiate cellular responses then modulate into gene expression.
Exogenous glucocorticoids gives negative feedback on HPA axis, so they reduces CHR and ATH release.
The risk of developing Iatrogenic Cushing Syndrome is often dose dependent.
It is prescribed by physicians in conditions like autoimmune diseases, inflammatory disorders, asthma, and organ transplantation.
An early identification and timely intervention treatment can help to improve prognosis.
The symptoms reversible upon discontinuation and tapering of glucocorticoid therapy.
The reversibility based on duration of exposure and susceptibility of individual.
Clinical History:
In children and adolescents if physician suggested glucocorticoids drugs, then it can lead to syndrome.
Pediatric patients are more vulnerable to glucocorticoid therapy effects.
Cardiovascular Examination
Musculoskeletal Examination
Joint Examination
Neurological and Psychological Assessment
Prolonged exposure to high levels of glucocorticoids can lead to decreased bone mineral density and an increased risk of osteoporosis. Iatrogenic Cushing Syndrome is associated with an increased risk of cardiovascular complications, including hypertension, atherosclerosis, and an elevated risk of cardiovascular events such as heart attacks and strokes.
Glucocorticoids can induce metabolic changes, including insulin resistance, impaired glucose tolerance, and an increased risk of developing diabetes mellitus.One of the characteristic features of Cushing Syndrome is central obesity, with an accumulation of fat around the abdomen and face.
This can contribute to weight gain and an increased risk of metabolic syndrome.Glucocorticoids can lead to muscle wasting and weakness, which may contribute to decreased physical function and exercise intolerance.
In many cases symptoms occurs gradual development over time with prolonged glucocorticoid use.
Initial body composition shows changes like weight gain and fat redistribution.
The systemic effects of glucocorticoids shows endocrine disturbances and menstrual irregularities.
Primary Adrenal Disease:
Exogenous Glucocorticoid Use
Pseudo-Cushing Syndrome
Adrenal function monitoring importance is essential during and after tapering process.
Psychological support is beneficial for mood changes or emotional distress.
Patients should follow a healthy diet and lifestyle can shows metabolic consequences of glucocorticoid therapy.
Endocrinology, Metabolism
A balanced and nutritious diet should be taken to support overall health.
Consume a variety of fruits, vegetables, whole grains, and lean proteins.
Do regular physical activity and exercise which can contribute to weight management and muscle strength.
Follow regular sleep patterns to support well-being.
Endocrinology, Metabolism
To give support and strength to bone health patient should take supplements like calcium and vitamin D.
Internal Medicine
Hydrocortisoneis a synthetic form of cortisol. It is used in the management of Iatrogenic Cushing Syndrome.
Endocrinology, Metabolism
The size and appearance of the adrenal glands is examined in the imaging studies.
DXA scans are used to determine bone mineral density. It helps in evaluation of glucocorticoid therapy on bone health and the risk of osteoporosis.
Endocrinology, Metabolism
The diagnosis phase involves the initial identification of the signs and symptoms of Cushing Syndrome. This includes central obesity, moon face, muscle weakness, and psychological changes.
On regular basis monitor adrenal function during the tapering process to assess recovery.
Schedule regular follow-up to monitor the patient’s progress.
Iatrogenic Cushing Syndrome is causes due to prolonged administration or overdose of glucocorticoid drug. It is a condition which develops because of medical interventions.
Glucocorticoids are widely suggested by physicians to treat various inflammatory and autoimmune conditions. This suppress the immune system in cases of organ transplantation.
This syndrome arises due to an excess level of cortisol. It is a steroid hormone which is derived from the adrenal glands.
The Prevalence is depending on population, duration, and dose of glucocorticoid therapy.
The high risk for patients is noticed with certain medical conditions due to prolonged use. For Short-term use the low-dose therapy is less likely to develop the syndrome.
The high-level dose of glucocorticoids and extended durations of treatment develops the risk of syndrome.
Prednisone and dexamethasone bind to glucocorticoid receptors in cells.
Glucocorticoids initiate cellular responses then modulate into gene expression.
Exogenous glucocorticoids gives negative feedback on HPA axis, so they reduces CHR and ATH release.
The risk of developing Iatrogenic Cushing Syndrome is often dose dependent.
It is prescribed by physicians in conditions like autoimmune diseases, inflammatory disorders, asthma, and organ transplantation.
An early identification and timely intervention treatment can help to improve prognosis.
The symptoms reversible upon discontinuation and tapering of glucocorticoid therapy.
The reversibility based on duration of exposure and susceptibility of individual.
Clinical History:
In children and adolescents if physician suggested glucocorticoids drugs, then it can lead to syndrome.
Pediatric patients are more vulnerable to glucocorticoid therapy effects.
Cardiovascular Examination
Musculoskeletal Examination
Joint Examination
Neurological and Psychological Assessment
Prolonged exposure to high levels of glucocorticoids can lead to decreased bone mineral density and an increased risk of osteoporosis. Iatrogenic Cushing Syndrome is associated with an increased risk of cardiovascular complications, including hypertension, atherosclerosis, and an elevated risk of cardiovascular events such as heart attacks and strokes.
Glucocorticoids can induce metabolic changes, including insulin resistance, impaired glucose tolerance, and an increased risk of developing diabetes mellitus.One of the characteristic features of Cushing Syndrome is central obesity, with an accumulation of fat around the abdomen and face.
This can contribute to weight gain and an increased risk of metabolic syndrome.Glucocorticoids can lead to muscle wasting and weakness, which may contribute to decreased physical function and exercise intolerance.
In many cases symptoms occurs gradual development over time with prolonged glucocorticoid use.
Initial body composition shows changes like weight gain and fat redistribution.
The systemic effects of glucocorticoids shows endocrine disturbances and menstrual irregularities.
Primary Adrenal Disease:
Exogenous Glucocorticoid Use
Pseudo-Cushing Syndrome
Adrenal function monitoring importance is essential during and after tapering process.
Psychological support is beneficial for mood changes or emotional distress.
Patients should follow a healthy diet and lifestyle can shows metabolic consequences of glucocorticoid therapy.
Endocrinology, Metabolism
A balanced and nutritious diet should be taken to support overall health.
Consume a variety of fruits, vegetables, whole grains, and lean proteins.
Do regular physical activity and exercise which can contribute to weight management and muscle strength.
Follow regular sleep patterns to support well-being.
Endocrinology, Metabolism
To give support and strength to bone health patient should take supplements like calcium and vitamin D.
Internal Medicine
Hydrocortisoneis a synthetic form of cortisol. It is used in the management of Iatrogenic Cushing Syndrome.
Endocrinology, Metabolism
The size and appearance of the adrenal glands is examined in the imaging studies.
DXA scans are used to determine bone mineral density. It helps in evaluation of glucocorticoid therapy on bone health and the risk of osteoporosis.
Endocrinology, Metabolism
The diagnosis phase involves the initial identification of the signs and symptoms of Cushing Syndrome. This includes central obesity, moon face, muscle weakness, and psychological changes.
On regular basis monitor adrenal function during the tapering process to assess recovery.
Schedule regular follow-up to monitor the patient’s progress.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Digital Certificate PDF
On course completion, you will receive a full-sized presentation quality digital certificate.
medtigo Simulation
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
medtigo Points
medtigo points is our unique point redemption system created to award users for interacting on our site. These points can be redeemed for special discounts on the medtigo marketplace as well as towards the membership cost itself.
Community Forum post/reply = 5 points
*Redemption of points can occur only through the medtigo marketplace, courses, or simulation system. Money will not be credited to your bank account. 10 points = $1.
All Your Certificates in One Place
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
