Incomplete Abortion

Updated: August 1, 2024

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Background

Partial pregnancy loss occurs within the first 20 weeks of gestation. It is also called as incomplete miscarriage or incomplete abortion.  

Miscarriage causes heavy vaginal bleeding, tissue passage, lower abdominal, pelvic pain in the form of moderate to severe symptoms. 

Diagnosis through visualizing pregnancy tissue in cervical or during examination. Ultrasound shows abnormal tissue in endometrial canal in patient with signs of miscarriage. 

Insufficient fetal development at certain stages indicates incomplete pregnancy loss diagnosis. 

Miscarriage before 10 to 13 weeks of pregnancy known as early pregnancy loss. Incomplete abortion is miscarriage subtype where products of conception are not fully expelled from uterus. 

Physicians use inevitable miscarriage term for an open cervical with symptoms of bleeding and cramping. 

Epidemiology

The incidence of incomplete miscarriage/abortion has not been well documented and studied. 

Spontaneous pregnancy loss incidence ranges from 10% to 15% in recognized pregnancies. 

Surgical and medical second-trimester abortion incomplete rates are 1% to 8%. 

34% of anembryonic gestations and 26% of pregnancies with embryonic demise had incomplete POC expulsion after 1 month. 

Anatomy

Pathophysiology

Pregnancy complications such as genetic abnormalities, infections, hormone imbalances, or maternal health issues can lead to abortion due to fetal death. 

Partial placental detachment causes maternal blood vessel exposure, that leads to vaginal bleeding from conception products. 

Retained tissue causes inflammation to release cytokines and mediators, that occurs uterine contractions and attempts to expel it. 

Decrease in pregnancy hormones can affect uterine contractions and completion of abortion process. 

Etiology

Unknown cause of incomplete POC expulsion after miscarriage or induced abortion observed. 

Spontaneous miscarriage occurs from various causes, with 50% due to embryonic chromosomal abnormalities in early pregnancy. 

Induced abortion can lead to incomplete passage of products of conception. WHO defines unsafe abortion as a procedure done without proper skills or in substandard medical conditions. 

Some risk factors are:  

Maternal age 

Maternal comorbidities 

Structural uterine abnormalities 

Teratogen exposure  

Genetics

Prognostic Factors

Expectant management for incomplete pregnancy loss gives 90% complete expulsion of POC within 4 weeks. 

Surgery, expectant, medical management have excellent prognosis as definitive treatment. 

Conception is considered safe after immediate miscarriage. 

Live birth rates are higher for conceptions within 3 months post-pregnancy loss compared to those who postpone. 

Clinical History

Incomplete pregnancy loss presents with the passage of clots or tissue, but patients may not always be aware of it. 

Heavy bleeding in incomplete miscarriage lasts longer and is heavier than usual periods defined as soaking 1 to 2 pads/hour for 2 hours. 

Clinicians should ask about symptoms including cramps, pelvic pain, and vaginal bleeding, pad usage, and clot size. 

Physical Examination

Pelvic examination  

Abdomen examination 

Age group

Associated comorbidity

Associated activity

Acuity of presentation

  • Symptoms as: 
  • Vaginal Bleeding  
  • Signs of Infection 
  • Hemodynamic Instability 
  • Abdominal Pain 

Differential Diagnoses

  • Complete miscarriage 
  • Molar pregnancy 
  • Hemorrhagic shock 
  • Uterine rupture 
  • Septic abortion 
  • Threatened miscarriage 

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

Expectant management involves close monitoring of stable patients without contraindications to allow natural miscarriage progression if infection signs are absent. 

Up to 53% of patients with first-trimester incomplete miscarriage see complete POC expulsion within one week without further treatment. 

WHO recommends vaginal misoprostol 800 mcg once initially, with second dose after 3 to 7 days. 

Research shows 96.2% of women with incomplete abortion had complete abortion within 14 to 28 days with misoprostol. 

Patients must seek medical help if they soak 2 pads per hour for ≤2 hours or shows dizziness, lightheadedness, and fever. 

Rh(D)-immune globulin is recommended for Rh-negative patients to prevent alloimmunization after surgery but controversial for early pregnancy loss. 

A follow-up appointment with a gynecologist for ultrasound or β-hCG tests is needed to confirm complete expulsion of gestational sac. 

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

use-of-non-pharmacological-approach-for-incomplete-abortion

The cleaning protocols should be strictly followed to prevent infections during surgery and to sterilize instruments/equipment. 

Maintain private, comfortable, and equipped space for patient examinations and treatments with respect for confidentiality. 

Take guidance from mental health professionals for emotional support and counseling. 

Healthcare providers should communicate clearly and compassionately with patients before/during process. 

Respect cultural beliefs and practices on pregnancy loss. Patient consent required for procedures. 

Proper education and awareness about abortion should be provided and its related causes with management strategies. 

Use of Uterotonic Agents

Misoprostol: 

It is a prostaglandin E1 analog that induces uterine contractions and helps to expel retained products. 

Use of Analgesics

Ibuprofen: 

It is used to manage pain and discomfort associated with uterine cramps and the expulsion process. 

use-of-intervention-with-a-procedure-in-treating-incomplete-abortion

Surgery recommended for incomplete pregnancy loss in unstable patients, high hemorrhage risk, or failed expectant management. 

Surgery is the most effective treatment, and this can be done through uterine aspiration or suction curettage in a clinic. 

use-of-phases-in-managing-incomplete-abortion

In the initial assessment phase, evaluation of medical history, physical examination, and laboratory test should be conducted. 

Pharmacologic therapy is very effective in the treatment phase as it includes use of uterotonic agents and surgical intervention. 

In management and care phase, provide emotional support to help the patient deal with the experience of pregnancy loss. 

The regular follow-up visits with the gynecologist are scheduled to check the improvement of patients along with treatment response. 

Medication

 

misoprostol 

(off-label):

600 mcg orally once



Dose Adjustments

Dosing Modifications
Renal impairment: not to use without caution; half-life, peak plasma concentration, and bioavailability may be enhanced, but it is not evident whether the increases are related to clinical relevance

 
 

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Incomplete Abortion

Updated : August 1, 2024

Mail Whatsapp PDF Image



Partial pregnancy loss occurs within the first 20 weeks of gestation. It is also called as incomplete miscarriage or incomplete abortion.  

Miscarriage causes heavy vaginal bleeding, tissue passage, lower abdominal, pelvic pain in the form of moderate to severe symptoms. 

Diagnosis through visualizing pregnancy tissue in cervical or during examination. Ultrasound shows abnormal tissue in endometrial canal in patient with signs of miscarriage. 

Insufficient fetal development at certain stages indicates incomplete pregnancy loss diagnosis. 

Miscarriage before 10 to 13 weeks of pregnancy known as early pregnancy loss. Incomplete abortion is miscarriage subtype where products of conception are not fully expelled from uterus. 

Physicians use inevitable miscarriage term for an open cervical with symptoms of bleeding and cramping. 

The incidence of incomplete miscarriage/abortion has not been well documented and studied. 

Spontaneous pregnancy loss incidence ranges from 10% to 15% in recognized pregnancies. 

Surgical and medical second-trimester abortion incomplete rates are 1% to 8%. 

34% of anembryonic gestations and 26% of pregnancies with embryonic demise had incomplete POC expulsion after 1 month. 

Pregnancy complications such as genetic abnormalities, infections, hormone imbalances, or maternal health issues can lead to abortion due to fetal death. 

Partial placental detachment causes maternal blood vessel exposure, that leads to vaginal bleeding from conception products. 

Retained tissue causes inflammation to release cytokines and mediators, that occurs uterine contractions and attempts to expel it. 

Decrease in pregnancy hormones can affect uterine contractions and completion of abortion process. 

Unknown cause of incomplete POC expulsion after miscarriage or induced abortion observed. 

Spontaneous miscarriage occurs from various causes, with 50% due to embryonic chromosomal abnormalities in early pregnancy. 

Induced abortion can lead to incomplete passage of products of conception. WHO defines unsafe abortion as a procedure done without proper skills or in substandard medical conditions. 

Some risk factors are:  

Maternal age 

Maternal comorbidities 

Structural uterine abnormalities 

Teratogen exposure  

Expectant management for incomplete pregnancy loss gives 90% complete expulsion of POC within 4 weeks. 

Surgery, expectant, medical management have excellent prognosis as definitive treatment. 

Conception is considered safe after immediate miscarriage. 

Live birth rates are higher for conceptions within 3 months post-pregnancy loss compared to those who postpone. 

Incomplete pregnancy loss presents with the passage of clots or tissue, but patients may not always be aware of it. 

Heavy bleeding in incomplete miscarriage lasts longer and is heavier than usual periods defined as soaking 1 to 2 pads/hour for 2 hours. 

Clinicians should ask about symptoms including cramps, pelvic pain, and vaginal bleeding, pad usage, and clot size. 

Pelvic examination  

Abdomen examination 

  • Symptoms as: 
  • Vaginal Bleeding  
  • Signs of Infection 
  • Hemodynamic Instability 
  • Abdominal Pain 
  • Complete miscarriage 
  • Molar pregnancy 
  • Hemorrhagic shock 
  • Uterine rupture 
  • Septic abortion 
  • Threatened miscarriage 

Expectant management involves close monitoring of stable patients without contraindications to allow natural miscarriage progression if infection signs are absent. 

Up to 53% of patients with first-trimester incomplete miscarriage see complete POC expulsion within one week without further treatment. 

WHO recommends vaginal misoprostol 800 mcg once initially, with second dose after 3 to 7 days. 

Research shows 96.2% of women with incomplete abortion had complete abortion within 14 to 28 days with misoprostol. 

Patients must seek medical help if they soak 2 pads per hour for ≤2 hours or shows dizziness, lightheadedness, and fever. 

Rh(D)-immune globulin is recommended for Rh-negative patients to prevent alloimmunization after surgery but controversial for early pregnancy loss. 

A follow-up appointment with a gynecologist for ultrasound or β-hCG tests is needed to confirm complete expulsion of gestational sac. 

OB/GYN and Women\'s Health

The cleaning protocols should be strictly followed to prevent infections during surgery and to sterilize instruments/equipment. 

Maintain private, comfortable, and equipped space for patient examinations and treatments with respect for confidentiality. 

Take guidance from mental health professionals for emotional support and counseling. 

Healthcare providers should communicate clearly and compassionately with patients before/during process. 

Respect cultural beliefs and practices on pregnancy loss. Patient consent required for procedures. 

Proper education and awareness about abortion should be provided and its related causes with management strategies. 

OB/GYN and Women\'s Health

Misoprostol: 

It is a prostaglandin E1 analog that induces uterine contractions and helps to expel retained products. 

OB/GYN and Women\'s Health

Ibuprofen: 

It is used to manage pain and discomfort associated with uterine cramps and the expulsion process. 

OB/GYN and Women\'s Health

Surgery recommended for incomplete pregnancy loss in unstable patients, high hemorrhage risk, or failed expectant management. 

Surgery is the most effective treatment, and this can be done through uterine aspiration or suction curettage in a clinic. 

OB/GYN and Women\'s Health

In the initial assessment phase, evaluation of medical history, physical examination, and laboratory test should be conducted. 

Pharmacologic therapy is very effective in the treatment phase as it includes use of uterotonic agents and surgical intervention. 

In management and care phase, provide emotional support to help the patient deal with the experience of pregnancy loss. 

The regular follow-up visits with the gynecologist are scheduled to check the improvement of patients along with treatment response. 

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