Plague

Updated: July 11, 2024

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

ciprofloxacin

ciprofloxacin is indicated for the treatment of plague
A dose of 500 to 750 mg of ciprofloxacin should be administered orally every 12 hours for 14 days

dihydrostreptomycin

Intramuscular administration of two grams of this medication per day, divided into two doses, is recommended
Therapy for at least ten days is advised

Dose Adjustments

Limited data is available

gentamicin

(Off-label)
Dosage Modifications
Renal dysfunction
Dosing Conventions
Dosage adjustment for renal dysfunction is 1.7 mg/kg dose every 8 hours and 5 mg/kg to 7 mg/kg dose per day.
CrCl > 50 mL/min: dosage adjustment is not required
CrCl 10 mL/min to 50 mL/min: give every 12 hours to 48 hours
CrCl < 10 mL/min: give every 48 hours to 72 hours
Once daily dosage with extended interval:

5 mg/kg by intramuscularly/intravenously for 10 days or 1st dose of 2 mg/kg intramuscularly/intravenously, after that 1.7 mg/kg intramuscularly/intravenously for 3 times a day for 10 days to 14 days or for 2 days. After this treatment, patients can be treated with 3rd line treatment like afebrile ciprofloxacin, doxycycline, or chloramphenicol

Future Trends