Thrombocytopenia

Updated: July 1, 2024

Background

Epidemiology

Anatomy

Pathophysiology

Etiology

Genetics

Prognostic Factors

Clinical History

Physical Examination

Age group

Associated comorbidity

Associated activity

Acuity of presentation

Differential Diagnoses

Laboratory Studies

Imaging Studies

Procedures

Histologic Findings

Staging

Treatment Paradigm

by Stage

by Modality

Chemotherapy

Radiation Therapy

Surgical Interventions

Hormone Therapy

Immunotherapy

Hyperthermia

Photodynamic Therapy

Stem Cell Transplant

Targeted Therapy

Palliative Care

Medication

hydroxyurea

mg/kg

Orally

once a day

15 mg per kg taken orally once a day

eltrombopag

Tablet

Oral

once a day

bivalirudin

(Off Label):

Initial dose: 0.15–0.2 mg/kg/hr intravenous; increase to 1.5–2.5 times the standard amount for aPTT

aminocaproic acid

Indicated for Fibrinolytic Bleeding
Initial dose: 4-5 gm intravenously or orally during the first hour, then 1-1.25 gm orally every hour
Or
Continuous intravenous infusion at 1 gm/hour
Continue for 8 hours or till the bleeding is controlled, It Should not exceed 30 gm in a day
Diminish the dose in renal, cardiac, or hepatic diseases
Control of bleeding with the severe thrombocytopenia as off-label
Initial dose:100 mg/kg intravenously over 30-60 minutes, Should not exceed 5 gm
Maintenance dose: 1-4 gm orally or intravenously every 4-8 hours for 1 gm/hour, Should not exceed 24 gm in a day
Hyphema
Topical gel for treatment of the traumatic hyphema of eye

melatonin

Take 20 mg of medication orally once a day at bedtime

lusutrombopag

Indicated for Thrombocytopenia
Start dosing eight days to two weeks before the scheduled process
Following the last dose, individuals should have to undergo the procedure
The suggested dose is 3 mg orally every day for seven days

eltrombopag

25 - 50

Tablet

Orally 

once a day

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