acetaminophen/pamabrom/pyridoxine

Action and Spectrum

Actions and Spectrum: 

The combination of acetaminophen, pamabrom, and pyridoxine in this medication provides a comprehensive approach to addressing multiple symptoms. acetaminophen relieves pain and reduces fever, pamabrom helps reduce fluid retention and bloating, and pyridoxine supports the body’s vitamin B6 needs.  

Drug Interaction

Adverse Reaction

Frequency not defined 

Laryngeal edema 

Angioedema 

Pruritic maculopapular rash 

Leukopenia 

Neutropenia 

Urticaria 

Agranulocytosis 

Pancytopenia 

Hepatotoxicity 

Anaphylactoid reaction 

Thrombocytopenia 

Thrombocytopenic purpura 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindications: 

• Hypersensitivity 
• Blood disorders 

Cautions: 

• Drug-drug interactions 
• Pregnancy  
• Lactation 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy category: C  

Breastfeeding warnings:  

The drug is excreted in the breast milk.  

Pregnant & lactating females are advised to check with healthcare professionals. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

The combination of acetaminophen, pamabrom, and pyridoxine in this medication provides a comprehensive approach to addressing multiple symptoms. acetaminophen relieves pain and reduces fever, pamabrom helps reduce fluid retention and bloating, and pyridoxine supports the body’s vitamin B6 needs. 

It’s important to note that the pharmacological effects of this combination medication can vary among individuals and may be influenced by factors such as dose, route of administration, and individual sensitivity.  

Pharmacodynamics: 

acetaminophen shows analgesic and antipyretic effects. 

pamabrom has a diuretic effect on the kidneys. 

pyridoxine helps provide vitamin B6 supplementation. 

Pharmacokinetics: 

acetaminophen is absorbed from the gastrointestinal tract after oral administration. It is extensively first-pass metabolized in the liver and is primarily metabolized to inactive compounds. The elimination half-life of acetaminophen is approximately 2 to 3 hours in adults. It is primarily excreted in the urine as glucuronide and sulfate conjugates. 

Pamabrom is a diuretic that promotes the excretion of water and electrolytes through the kidneys. It is absorbed after oral administration. The exact pharmacokinetic parameters of pamabrom are not widely documented, but it is likely to undergo renal elimination. 

pyridoxine, or vitamin B6, is absorbed from the gastrointestinal tract after oral administration. It is converted to its active form, pyridoxal phosphate, in the liver. pyridoxine has a relatively short half-life of about 15 to 20 hours and is primarily excreted unchanged in the urine with its metabolite. 

Adminstartion

Administration: 

The administration of acetaminophen/pamabrom/pyridoxine combination medication typically follows the general guidelines for oral administration. The combination medication is usually taken by mouth with water. It may be available in tablets, capsules, or liquid.

Patient Information Leaflet

Patient information leaflet 

Generic Name: acetaminophen/pamabrom/pyridoxine 

Why do we use acetaminophen/pamabrom/pyridoxine? 

acetaminophen/pamabrom/pyridoxine is a combination medication commonly used to relieve premenstrual syndrome (PMS) symptoms, including pain, bloating, and mood disturbances.