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Brand Name :
Edex Refill Caverject, Prostin VR Pediatric, Edex, Muse, Prostin VR Pediatric, Caverject Impulse
Synonyms :
Class :
Impotence agents and Vasodilators
Dosage Forms & Strengths
Solution
500mcg/ml
1-40 mcg injected to the lateral penis over 5-10 seconds 3 times per week, with at least 1 day between each use
Dosage Forms & Strengths
Solution
500mcg/m
Indicated for ductus arteriosus
Age: <28 days
Initially 0.05-0.1 mcg/kg/min IV, may be increased up to 0.01-0.4 mcg/kg/min
may enhance the adverse/toxic effect of alprostadil
may enhance the adverse/toxic effect of alprostadil
may enhance the adverse/toxic effect of alprostadil
may increase the toxic effect of Phosphodiesterase 5 Inhibitors
the risk or extent of hypotension and priapism can be increased when fostamatinib is combined with alprostadil
Adverse drug reactions:
Frequency defined
>10%
Flushing (>10%)
Apnea (12%)
1-10%
Tachycardia (3%)
Intravascular coagulation (1%)
Edema (1%)
Seizures (4%)
Bradycardia (7%)
Hypotension (4%)
Diarrhea (2%)
Cardiac arrest (1%)
Hypokalemia (1%)
Sepsis (2%)
<1%
Cerebral bleeding
Hyperextension of the neck
Hyperirritability
Hypothermia
Tachypnea
Supraventricular tachycardia
Ventricular fibrillation
Lethargy
Stiffness
Jitteriness
Hyperemia
Second degree heart block
Hyperbilirubinemia
Congestive heart failure
Shock
Bradypnea
Bronchial wheezing
Gastric regurgitation
Hypercapnia
Respiratory depression
Respiratory distress
Pregnancy warnings:
US FDA pregnancy category: C (suppositories)
Lactation:
Excreted into human milk is Unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: alprostadil IV
Why do we use alprostadil IV?
alprostadil IV is an Impotence agent and Vasodilators used to treat Erectile Dysfunction.