aluminium Phosphate

Action and Spectrum

Actions and Spectrum: 

Aluminium phosphate is a medication used to bind phosphate in the gastrointestinal tract. Its action involves binding dietary phosphate in the gut, preventing its absorption and subsequently reducing serum phosphate levels.

This can be particularly useful in conditions where there is an excess of phosphate, such as in certain kidney diseases or in the management of hyperphosphatemia in dialysis patients. 

Drug Interaction

Adverse Reaction

Frequency not defined  

constipation 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Allergy or hypersensitivity: Individuals who have a known allergy or hypersensitivity to aluminium or any other ingredient present in the aluminium phosphate formulation should avoid its use. 

Kidney impairment: People with severe kidney problems or impaired renal function may experience difficulties in excreting aluminium, which can lead to toxicity. Therefore, aluminium-containing medications, including aluminium phosphate, should be avoided, or used with caution under medical supervision in such cases. 

Dehydration: Aluminium phosphate may potentially worsen dehydration due to its ability to bind to phosphate ions. It is advisable to avoid its use in individuals who are severely dehydrated or at risk of dehydration. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

Pharmacodynamics:  

Aluminium phosphate functions as a neutralizing agent in the stomach, aiding in reducing acidity. It reacts with excess stomach acid to form aluminium chloride and phosphoric acid, thereby helping to alleviate symptoms associated with conditions like acid reflux or indigestion. 

Pharmacokinetics: 

N/A 

Adminstartion

Administration:  

For the liquid form, measure the dose precisely using a measuring device provided with the medication. Shake well before use. 

Some forms of aluminium phosphate may need to be mixed with water or other liquids according to the instructions before administration. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: aluminium phosphate 

Why do we use aluminium phosphate?  

An antacid aluminium phosphate is used to counteract stomach acid and relieve heartburn symptoms, acid indigestion, and upset stomach. In dentistry, aluminum phosphate might be used in some dental cement or materials for procedures like tooth restoration.