Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Cytadren, Elipten, Orimeten
Synonyms :
2-(p-Aminophenyl)-2-ethylglutarimide
Class :
Adrenal corticosteroid inhibitors
Brand Name :
Cytadren, Elipten, Orimeten
Synonyms :
2-(p-Aminophenyl)-2-ethylglutarimide
Class :
Adrenal corticosteroid inhibitors
Dosage Forms & Strengths
Tablets
250mg
250
mg
Tablets
Orally 
twice a day
Note:
in case of insufficient cortical suppression, the dose can be increased up to 2g for 7 to 14 days
250
mg
Tablets
Orally 
twice a day
The dose can be increased to 250mg orally every 6 hours after 14 days. The dose range may be 250mg to 1g per day
250
mg
Tablets
Orally 
twice a day
The dose can be increased to 250mg orally every 6 hours after 14 days
The dose range may be 250mg to 1g per day
Data not available
Refer to adult dosing
aminoglutethimide increases the rate of metabolism of aminophylline
The severity of methemoglobinemia can be increased when ambroxol is taken with aminoglutethimide
aminoglutethimide increases the rate of metabolism of chlorpromazine
aminoglutethimide reduces the concentration of clozapine in serum
When aminoglutethimide is used together with norelgestromin, this leads to a rise in norelgestromin’s metabolism
The efficacy of clobetasone can be decreased when administered with aminoglutethimide
the efficacy of dexamethasone may be reduced with aminoglutethimide
an increase in the metabolism of docetaxel can be observed when administered with aminoglutethimide
An increase in the metabolism of ergotamine can be observed when administered with aminoglutethimide
when both drugs are combined, there may be a high metabolism of paclitaxel 
the therapeutic activity of ulobetasol may be reduced
When aminoglutethimide is used together with lomitapide, this leads to an enhancement in lomitapide’s metabolism
Actions and spectrum:
The adrenal cortex is a region of the body that is affected by aminoglutethimide. In addition to its other effects, it influences the production of steroids.
Certain tumors that impact the adrenal cortex can be treated with aminoglutethimide medication. Additionally, it is occasionally employed in cases of hyperactive adrenal cortex that are not malignant.
Frequency not defined
Breathing difficulties
Itching
Rashes on the skin
Swelling of tongue, lips, or face
Weakness
Nausea
Loss of appetite
Vomiting
Blurred vision
Black Box Warning
Avoid driving vehicles when taking aminoglutethimide
Contraindication/Caution:
Contraindication:
hypothyroidism
Pregnancy consideration:
US FDA pregnancy category: D
Lactation:
No data is available to show the excretion of aminoglutetimide in breast milk. However, keeping in view the effects of aminoglutethimide, it should be given to feeding mothers depending on the need.Â
Pregnancy category:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacology:
Pharmacodynamics:
The enzymatic conversion of cholesterol to Δ5-pregnenolone is inhibited by aminoglutethimide, which lowers the amount of androgens, estrogens, and mineralocorticoids produced by the adrenal glands. By binding to cytochrome P-450 complexes, aminoglutethimide inhibits a number of additional steroid synthesis steps, such as the hydroxylations necessary for the aromatization of androgens to estrogens (C-11, C-18, and C-21 hydroxylations).
Pharmacokinetics:
Absorption
aminoglutethimide is rapidly absorbed in the gastrointestinal tractÂ
Distribution
21- 25% of the drug is known to be protein-bound
Metabolism
Metabolism of aminoglutethimide occurs in the liver. In 48 hours, about 34-54% of the unchanged drug is excreted through urine and remaining as N-acetyl derivative
Elimination and excretion
about 34-54% of the unchanged drug is excreted through urine and remaining as N-acetyl derivative
Half-life:
12.5± 1.6 hours
Administration:
aminogluthetimide is administered orally as a tablet. Do not drive vehicles, as the drug may cause drowsiness.
Patient information leaflet
Generic Name: aminoglutethimide
Pronounced: a-mee-noe-gloo-TETH-i-mide
Why do we use aminoglutethimide?
In the treatment of prostate cancer and breast cancer, aminogluthetimide is used. It was also used to treat epilepsy.
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