2025 Guidelines for the Evaluation and Management of Adults With Congenital Heart Disease
December 19, 2025
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Brand Name :
Larither,Arteo,Falcimal,Shield,Alzenther
Synonyms :
artemether
Class :
Anti-malarial, Anti-parasitic agents
Brand Name :
Larither,Arteo,Falcimal,Shield,Alzenther
Synonyms :
artemether
Class :
Anti-malarial, Anti-parasitic agents
Dosage Forms & Strengths
Intramuscular injection
80mg/ml (1ml ampoule)
Administer 80mg/ml of one ampoule intramuscularly.
Do not administer intravenously.
If less than 1 milliliter is needed, use a 1-milliliter syringe with a 0.01-milliliter graduation.
Dosage Forms & Strengths
Intramuscular injection
80mg/ml (1ml ampoule)
Administer 3.2 mg/kg intramuscularly and continue with a daily dose of 1.6 mg/kg.
Administer 3.2 mg/kg intramuscularly and continue with a daily dose of 1.6 mg/kg.
Administer 3.2 mg/kg intramuscularly and continue with a daily dose of 1.6 mg/kg.
Refer adult dosing
when both drugs are combined, there may be an increase in qtc interval
when both drugs are combined, there may be increased toxicity of artemether by QTC interval
artemether and loperamide are both known to elevate the QTc interval
It may enhance QTc interval when combined with lithium
QTc interval increases on taking artemether and lenvatinib together. Avoid or take an alternate drug
when both drugs are combined, both increase the QTC interval
when both drugs are combined, both increase the QTC interval
both lapatinib and artemether increase the QTc interval
CYP3A enhancers reduces plasma concentrations of the active metabolite(s) of artemether
when both drugs are combined, there may be an increase in the QTC interval
may increase the QTc interval when combined
It may enhance QTc interval when combined with pentamidine
may increase the serum concentration of cardiac glycosides
may increase the serum concentration of cardiac glycosides
may increase the serum concentration of cardiac glycosides
Combining artemether with pranlukast may cause a reduction in the artemether’s metabolism
when ajmaline is used together with artemether, the risk or seriousness of QTc prolongation is enhanced
When dexrabeprazole and artemether is used together, this leads to reduction in the dexrabeprazole’s metabolism
When artemether is used together with fluconazole, this leads to reduction in the artemether metabolism
When artemether is used together with capsaicin, this leads to enhanced risk or seriousness of methemoglobinemia
When ponesimod is used together with artemether, this leads to enhanced risk or seriousness of bradycardia
When artemether is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When artemether is used together with givinostat, this leads to enhanced risk or severity of Qtc prolongation
When artemether is used together with acepromazine, this leads to enhanced risk or seriousness of QTc prolongation
When indisulam is used together with artemether, this leads to a reduction in artemether metabolism
the metabolism of artemether may be decreased when combined with indalpine
the hazard or seriousness of QTc prolongation can be heightened when digitoxin is combined with artemether
may increase the serum concentration of CYP2D6 substrates
may decrease the serum concentration of tamoxifen by increasing CYP2D6 substrates
the effect of artemether/lumefantriine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
when both drugs are combined, there may be an increased QTC interval
It may enhance the serum concentration of pizotifen
glycopyrrolate inhaled and formoterol
may increase the QTc interval when combined
the risk of QTc prolongation may be increased
Actions and Spectrum
The mode of action of the peroxide antimalarials is believed to be associated with their reaction with heme, a product of hemoglobin catabolism in the food vacuole of the parasite. This process results in the formation of toxic radicals which have a negative impact on cells. The peroxide containing drugs produce different toxic oxygen and carbon centred radicals when they undergo reaction with heme.
Frequency not defined
Bradycardia
QTc prolongation
Black box warning
None
Contraindication/caution
Hypersensitivity
Concomitant Use with Neurotoxic Drugs
QT Prolongation and Arrhythmias
Hepatic impairment
Renal impairment
Pregnancy/Lactation
Pregnancy consideration: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Pregnancy Category: C
Lactation: Excretion of drug in human breast milk is known
Pregnancy category:
Pharmacology
Artemether is widely used in malaria treatment and is classified under the artemisinin group of drugs. It operates by generating reactive oxygen species (ROS) and free radicals when exposed to heme or ferrous iron (Fe2 +) inside the malaria parasite. These reactive molecules destroy the necessary proteins and membranes in the parasite, which in turn causes the death.
Pharmacodynamics
Artemether which is the active component of Co-artemether is metabolized within the body to form dihydroartemisinin. This drug primarily acts on the erythrocytic forms of P. falciparum through preventing synthesis of nucleic acids and proteins. It is typically combined with artemether which increases Its efficacy in the eradication of the Plasmodium parasite. Artemether has a fast pharmacological effect, it does not stay long within the human body and effectively cuts the number of malarial parasites, thereby quickly alleviating the symptoms of the disease. Lumefantrine, due to its longer half-life, is expected to clear any parasites that may be present.
Pharmacokinetics
Absorption
Food increases absorption
Distribution
Protein binding:
Artemether: 95.4%
Lumefantrine: 99.7%
Dihydroartemisinin: 47% to 76%
Metabolism
Rapidly metabolized to its active metabolite, dihydroartemisinin (DHA)
Elimination
Half-life of Artemether: 1.6 ± 0.7 and 2.2 ± 1.9 hours
Administration
It is given in the form intramuscular injection
Patient information leaflet
Generic Name: artemether
Why do we use artemether?
Artemether is a malarial drug administered together with lumefantrine in the management of acute uncomplicated P.falciparum malaria.
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