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Brand Name :
Genpram D
Synonyms :
lumefantrine
Class :
Antimalarials
Brand Name :
Genpram D
Synonyms :
lumefantrine
Class :
Antimalarials
Dosage Forms & Strengths
Tablet/capsule
120 mg
240 mg
480 mg
480 mg is given orally as Initial dose and then Repeated after every 8,24,36,48 & 60 hours
Dosage Forms & Strengths
Tablet/capsule
120 mg
240 mg
480 mg
Neonates: 15 mg/kg is given orally as Initial dose, then repeated after 8 hours, 24 hours and 48 hours of first dose
5 to 14 kg child: 120 mg is given orally as Initial dose and then Repeated after every 8,24,36,48 & 60 hours
15 to 24 kg child: 240 mg is given orally
25 to 34 kg child: 360 mg is given orally
Refer to the adult dosing regimen
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increased hepatotoxic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased hepatotoxic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased hepatotoxic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased hepatotoxic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased hepatotoxic effect when combined with serotonin/norepinephrine reuptake inhibitors
When nafcillin combines with lumefantrine, nafcillin will decrease the effect of action of lumefantrine by affecting enzyme CYP3A4 metabolism.
when used together, entrectinib and lumefantrine both increase the QTc interval
when used together, encorafenib and lumefantrine both increase the QTc interval
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
may have an increasingly adverse effect when combined with selective serotonin reuptake inhibitors
they increase the toxicity of metformin
alcoholic products increase the toxicity of secnidazole
alcohol increases the toxicity of nifurtimox
cannabis: they may increase the CNS depressant effect of amino alcohol
CNS depressants increase the CNS depressing effect of alcohol
CNS depressants increase the CNS depressing effect of alcohol
CNS depressants increase the CNS depressing effect of alcohol
CNS depressants increase the CNS depressing effect of alcohol
CNS depressants increase the CNS depressing effect of alcohol
It may diminish the effect when combined with griseofulvin by CYP3A4 metabolism
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
When encainide is used together with lumefantrine, this leads to a reduction in the encainide’s metabolism
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increasingly adverse effect when combined with NSAIDs
may have an increasingly adverse effect when combined with NSAIDs
may have an increasingly adverse effect when combined with NSAIDs
may have an increasingly adverse effect when combined with NSAIDs
may have an increasingly adverse effect when combined with NSAIDs
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the orthostatic hypotensive effect of thiazide diuretics
may have an increasingly adverse effect when combined with NSAIDs
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
spironolactone and hydrochlorothiazide
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increased orthostatic hypotensive effect when combined with thiazide diuretics
may have an increasingly adverse effect when combined with NSAIDs
may increase the serum concentration of CYP2D6 substrates
the effect of artemether/lumefantriine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
May increase the tachycardic effect (hypertension)
may enhance the bioavailability of tiopronin
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may increase the orthostatic hypotensive effect of thiazide diuretics
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased CNS depressant effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased adverse/toxic effect when combined with alcohol
may have an increased Effect of CNS depressant when combined with alcohol
may have an increased Effect of CNS depressant when combined with alcohol
may have an increased Effect of CNS depressant when combined with alcohol
may decrease the level by affecting the hepatic enzyme CYP3A4 metabolism
Actions and spectrum:
Lumefantrine, often used with artemether, is a key treatment for malaria from Plasmodium falciparum. Even drug-resistant strains are targeted. As part of artemisinin combination therapy, it fights malaria parasites inside red blood cells. Lumefantrine disrupts these parasites, stopping reproduction.
It specifically targets Plasmodium falciparum, the deadliest malaria type. When combined with other drugs, lumefantrine treats uncomplicated malaria cases. This combination therapy also helps prevent drug resistance.
Frequency not defined
Weakness
Headache
Nausea
Diarrhea
Palpitation
Cough
GI disturbance
Stiffness
Dizziness
Rash
Vomiting
Myalgia
Sleep disturbance
Pleuritis
Muscle pain
Loss of appetite
Black Box Warning:
lumefantrine does not typically have a black box warning.
Contraindication/Caution:
Contraindication:
Caution:
Comorbidities:
Pregnancy consideration: pregnancy category: not assigned
Lactation: excreted into human milk: unknown
Pregnancy category:
Category N: There is no data available for the drug under this category.
Pharmacology:
Lumefantrine, combined with artemether, treats malaria. It stops malaria parasites from multiplying in red blood cells. It does this by disrupting their electron transport chain. Lumefantrine absorbs quickly when taken with food due to its high lipophilicity – this enhances its effectiveness. A specific dosing regimen maintains good blood levels despite a long elimination half-life. This ensures parasite clearance. Lumefantrine’s pharmacokinetic profile, coupled with artemether’s rapid action, makes it effective against malaria.
Pharmacodynamics:
Lumefantrine is a medicine used to treat malaria. Its antimalarial action works by disturbing the malaria parasite’s energy production system in its mitochondria. This disrupts the parasite’s ability to make energy, preventing it from replicating and spreading. In addition to treating active malaria infections, lumefantrine also provides protection against future infections for some time after treatment. Although slower-acting than artemether, lumefantrine helps eliminate any remaining parasites after the initial rapid impact of artemether. When used together, lumefantrine and artemether work very well against malaria. Artemether quickly reduces the number of parasites in the body, while lumefantrine continues to clear out the remaining parasites over a longer period. Lumefantrine’s ability to dissolve in fats helps it get absorbed into the bloodstream more efficiently when taken with food, increasing its effectiveness.
Pharmacokinetics:
Absorption
After taking lumefantrine orally, it gets absorbed slowly. It takes around 6 to 8 hours to reach the highest level in the blood.
Distribution
Lumefantrine moves throughout the body and attaches tightly to proteins, especially albumin. This makes it go into various tissues and organs.
Metabolism
The liver breaks down lumefantrine using enzymes called CYP3A4. The main metabolite, or breakdown product, is desbutyl-lumefantrine.
Elimination and excretion
Lumefantrine and its metabolites leave the body through urine. However, they take a long time to get eliminated, with a half-life of 3 to 6 days.
Administration:
Lumefantrine dosages can change based on your age, weight, and product type. Usually, you swallow lumefantrine pills. It works best if you take it with a fatty meal or milk to help your body absorb it properly. A meal with around 45 grams of fat is recommended.
You’ll take lumefantrine twice a day for three days, so six doses total. Swallow the pills whole; don’t chew or crush them. You can take them with water or another drink.
Patient information leaflet
Generic Name: lumefantrine
Pronounced: (loo-muh-FAN-treen)
Why do we use lumefantrine?
Lumefantrine works together with artemether to fight malaria. This mix kills the parasite called Plasmodium falciparum. It treats malaria where the parasite hasn’t become resistant. People take this medicine for malaria they already have, not to prevent it. For it to work right, doctors need to test for and find malaria early. The medicine is used in places where malaria is common and spreading among people.
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