DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency defined:  

>10% 

Dizziness 

Somnolence 

Anorexia 

1-10% 

Agitation 

Ataxia 

Abdominal pain 

Depression 

Insomnia 

Paresthesia 

Constipation 

Weight loss 

Mental slowing 

Xerostomia 

Taste perversion 

<1% 

Allergic reaction 

Anemia 

Leg cramps 

Pharyngitis 

Amblyopia 

Urticaria 

Acne 

Euphoria 

Vertigo 

Apnea 

Post-marketing reports 

Acute pancreatitis 

Acute myopia 

Encephalopathy 

Pregnancy consideration: C 

Lactation: The drug is excreted in the human breast milk 

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: No data is available for the drug under this category. 

Patient information leaflet 

Generic Name: zonisamide 

Pronounced: zoh-NIH-sah-mide 

Why do we use zonisamide? 

It is used to treat partial seizures.