Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
TEVA-Betahistine, Auro-Betahistine; PMS-Betahistine; Serc
Synonyms :
betahistine
Class :
Histamine H3 Antagonist Histamine H1 Agonist
Brand Name :
TEVA-Betahistine, Auro-Betahistine; PMS-Betahistine; Serc
Synonyms :
betahistine
Class :
Histamine H3 Antagonist Histamine H1 Agonist
Dosage Forms & Strengths
Tablet
Generic
24mg
16mg
8mg
Serc
24mg
16mg
Indicated for Chronic Management of Meniere disease
:
Initial dose- Administer 24 mg to 48mg /day in two or three divided doses
Begin with a lesser dosage (e.g., 8 to 16 mg daily once) and gradually increase to twice daily, then three times daily depending on response and tolerability.
Taper and stop after three to six months in order of consistent management.
Indicated for Chronic Management of Meniere disease
:
Initial dose- Administer 24 mg to 48mg /day in two or three divided doses
Begin with a lesser dosage (e.g., 8 to 16 mg daily once) and gradually increase to twice daily, then three times daily depending on response and tolerability.
Taper and stop after three to six months in order of consistent management.
Safety and efficacy not established
Refer adult dosing
betahistine: they may increase the CNS depressant effect of CNS Depressants
betahistine: they may increase the CNS depressant effect of CNS Depressants
betahistine: they may increase the CNS depressant effect of CNS Depressants
betahistine: they may increase the CNS depressant effect of CNS Depressants
betahistine: they may increase the CNS depressant effect of CNS Depressants
may decrease the therapeutic effect of betahistine
may decrease the therapeutic effect of betahistine
may decrease the therapeutic effect of betahistine
may decrease the therapeutic effect of betahistine
may decrease the therapeutic effect of betahistine
may enhance the serum concentration when combined
may enhance the serum concentration when combined
may enhance the serum concentration when combined
may enhance the serum concentration when combined
may enhance the serum concentration when combined
betahistine's therapeutic efficacy may be reduced by antihistamines
betahistine's therapeutic efficacy may be reduced by antihistamines
betahistine's therapeutic efficacy may be reduced by antihistamines
betahistine's therapeutic efficacy may be reduced by antihistamines
dexchlorpheniramine, dextromethorphan, and phenylephrine
betahistine's therapeutic efficacy may be reduced by antihistamines
betahistine: it may increase the risk or severity of QTc prolongation agents
betahistine: it may increase the risk or severity of QTc prolongation agents
betahistine: it may increase the risk or severity of QTc prolongation agents
betahistine: it may increase the risk or severity of QTc prolongation agents
betahistine: it may increase the risk or severity of QTc prolongation agents
Actions and Spectrum:
The spectrum of activity of betahistine is primarily focused on its effects on the inner ear and vestibular system. It is not a broad-spectrum antimicrobial agent or a treatment for systemic infections.
Frequency defined
1-10%
Nausea
Headache
Dyspepsia
Frequency not defined
Hypotension
Pruritus
Anaphylaxis
Dyspnea
Abdominal pain
Angioedema
Black box warning:
None
Contraindications/caution:
Contraindications:
Hypersensitivity reactions
Caution:
Pregnancy consideration: Insufficient data available. Adverse outcomes were documented in specific animal reproductive trials.
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
betahistine pharmacology involves several mechanisms of action:
Pharmacokinetics:
Absorption
betahistine is rapidly and completely absorbed when taken orally. The absorption can be delayed when the medication is taken with food. It takes approximately 1 hour to reach peak levels of its inactive metabolite in the bloodstream.
Distribution
betahistine has minimal protein binding, with less than 5% bound to plasma proteins.
Metabolism
betahistine undergoes rapid and almost complete hepatic metabolism, primarily converting to its inactive metabolite called 2-pyridylacetic acid.
Elimination and Excretion
The half-life of the inactive metabolite of betahistine is approximately 3.5 hours. betahistine and its inactive metabolite are primarily excreted in the urine. Approximately 91% of the administered dose is eliminated in the urine, mainly as the inactive metabolite.
Administration:
Oral administration
Administer with or without the food; if adverse gastrointestinal (GI) effects occur, administer with food.
Patient information leaflet
Generic Name: betahistine
Why do we use betahistine?
betahistine is primarily used to treat vertigo and symptoms associated with Ménière’s inner ear disease.
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