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Brand Name :
Prolensa,BromSite
Synonyms :
bromfenac
Class :
Nonsteroidal Anti-inflammatory Disease, Ophthalmic
Brand Name :
Prolensa,BromSite
Synonyms :
bromfenac
Class :
Nonsteroidal Anti-inflammatory Disease, Ophthalmic
Dosage Forms & Strengths
Ophthalmic Solution
0.07%
0.09%
0.075%
Indicated for Cataract Post-Operative Ocular Pain/Inflammation:
0.07% and 0.09% Ophthalmic Solution: Instill 1 drop to each affected eye once a day prior to 1 day before cataract surgery and through post-operative period of 14 days
0.075% Ophthalmic Solution: Instill 1 drop to each affected eye twice a day before one day before cataract surgery and through a postoperative period of 14 days
Indicated for Cataract Post-Operative Ocular Pain/Inflammation:
0.07% and 0.09% Ophthalmic Solution: Instil 1 drop to each affected eye once a day prior to 1 day before cataract surgery and through post-operative period of 14 days
0.075% Ophthalmic Solution: Instil 1 drop to each affected eye twice a day before one day before cataract surgery and through a postoperative period of 14 days
Safety and efficacy not established
Refer adult dosing
may increase the toxic effect of Nonsteroidal Anti-Inflammatory Agents
may increase the toxic effect of Nonsteroidal Anti-Inflammatory Agents
may increase the toxic effect of Nonsteroidal Anti-Inflammatory Agents
may increase the toxic effect of Nonsteroidal Anti-Inflammatory Agents
may increase the toxic effect of Nonsteroidal Anti-Inflammatory Agents
may decrease the therapeutic effect of Nonsteroidal Anti-Inflammatory Agents
may decrease the therapeutic effect of Nonsteroidal Anti-Inflammatory Agents
When bromfenac is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When melitracen is used together with bromfenac, this leads to increased risk or seriousness of gastrointestinal bleeding
When bromfenac is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When bromfenac is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
When bromfenac is used together with benoxaprofen, this leads to enhanced risk or seriousness of adverse events
When bromfenac is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When bromfenac is used together with difenpiramide, this leads to increased risk or seriousness of adverse events
Mechanism of action
bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are responsible for prostaglandins. Prostaglandins are involved in inflammation and pain, and by inhibiting their production, bromfenac can help reduce these symptoms
Spectrum
bromfenac is primarily used to treat inflammation and pain associated with cataract surgery or other ocular surgeries. It has a relatively narrow spectrum of activity and is most effective at reducing inflammation and pain in the eye. However, it may also be used to treat other types of pain and inflammation, such as arthritis, though other NSAIDs are typically used for these conditions
Frequency undefined:
Conjunctival hyperemia
Eye pain
Eye redness
Iritis
Abnormal sensation in eye
Eye irritation
Eye pruritis
Headache
Corneal erosion
Contraindications
None
Caution
Pregnancy consideration:
bromfenac is not recommended for use during pregnancy as it may harm the developing fetus or nursing baby
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the activity of cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins. Prostaglandins are involved in inflammation and pain, and by inhibiting their production, bromfenac can help reduce these symptoms
bromfenac is available in several formulations, including oral tablets, eye drops, and injections. Eye drops are the most commonly used formulation and are primarily used to treat inflammation and pain associated with cataract surgery or other ocular surgeries
Pharmacodynamics
The pharmacodynamics of bromfenac involves its effects on the body and its mechanism of action. As a nonsteroidal anti-inflammatory drug (NSAID), bromfenac inhibits the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2
COX enzymes are responsible for prostaglandins, which are involved in inflammation and pain. By inhibiting COX enzymes, bromfenac reduces the production of prostaglandins, thereby reducing inflammation and pain
Pharmacokinetics
Absorption
bromfenac can be administered via oral tablets, eye drops, and injections. bromfenac is rapidly and completely absorbed from the gastrointestinal tract when taken orally. bromfenac is absorbed through the cornea and enters the systemic circulation when applied as eye drops. Injection allows for direct systemic administration
Distribution
bromfenac is highly protein-bound (more than 98%), which limits its distribution in the body. It is distributed throughout the body, including into the eye’s aqueous humour
Metabolism
bromfenac is primarily metabolized in the liver, which undergoes oxidative biotransformation. The metabolites are then excreted in the urine
Elimination/Excretion
bromfenac and its metabolites are excreted mainly in the urine, with a smaller amount excreted in the faeces
Administration
bromfenac can be administered via several routes, including oral tablets, eye drops, and injections. The choice of administration route depends on the indication and the patient’s needs
Patient information leaflet
Generic Name: bromfenac
Why do we use bromfenac?
bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to reduce inflammation and pain in the eye after cataract surgery or other ocular surgeries. It is available as an ophthalmic solution (eye drops) and is used for a short period, typically two weeks, after surgery,
bromfenac prevents or treats inflammation and pain associated with cataract surgery or other ocular surgeries. It works by reducing the production of prostaglandins, which are involved in inflammation and pain
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