- March 15, 2022
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Brand Name :
Myleran, Busulfex, PMS-Busulfan
Synonyms :
Class :
Dosage forms with strengths:
As premedications such as anti-seizures and antiemetics are recommended prior to 12hour of busulfan treatment.
Continue the premedications after 24 hours of the last busulfan dose.
Injectable solution: 6mg/ml (10ml)
Tablet: 2mg (orally take it on an empty stomach to decrease the risk of N/V)
Pre-medication:
Anticonvulsants: levetiracetam, phenytoin, benzodiazepines, valproic acid
Antiemetics: domperidone
Conditioning regimen or so-called preparative regimen: A combination of chemotherapeutic agents may be used with or without radiation therapy.
IV (beginning 7 days before transplant for high-risk leukemic patients): 0.8mg/kg/dose every 6 hours for 4 days followed by cyclophosphamide prior to stem cell transplant.
Remission induction therapy: 60mcg/kg/day or 1.8 mg/m2, 4-8 mg orally once a day.
Maintenance therapy: Reduce the dose to 1-4mg/day to 2mg/week orally if WBC 10,000-20,000 cells/mm3 or put it on hold if leukocyte count <15,000/mcL. Resume the therapy when leukocyte count reaches approx. 50,000/mcL.
Examine monthly: CBC, Hgb, LFTs
Initial oral therapy: 2 to 4 mg once daily
Reduce the dose to 2 mg once daily, if platelets < 200,000 mm3 or WBC < 3,000/mm3.
Dosage forms with strengths:
As premedications such as anti-seizures and antiemetics are recommended prior to 12hour of busulfan treatment.
Continue the premedications after 24 hours of the last busulfan dose.
Injectable solution: 6mg/ml (10ml)
Tablet: 2mg (orally take it on an empty stomach to decrease the risk of N/V)
Dosage forms with strengths:
As premedications such as anti-seizures and antiemetics are recommended prior to 12hour of busulfan treatment.
Continue the premedications after 24 hours of the last busulfan dose.
Injectable solution: 6mg/ml (10ml)
Tablet: 2mg (orally take it on an empty stomach to decrease the risk of N/V)
Interaction with busulfan can diminish the therapeutic effect of the vaccine. Live-attenuated Vaccines should be avoided for 3 months after ending immunosuppressive therapy.
Interaction with busulfan can diminish the therapeutic effect of the vaccine. Live-attenuated Vaccines should be avoided for 3 months after ending immunosuppressive therapy.
Interaction with busulfan can diminish the therapeutic effect of the vaccine. Live-attenuated Vaccines should be avoided for 3 months after ending immunosuppressive therapy.
May increase the immunosuppressive effect of tucatinib
May increase the immunosuppressive effect of tofacitinib
It may enhance the effect when combined with lonafarnib by affecting CYP3A4 metabolism
It may enhance the immunosuppressive effects when combined with idecabtagene vicleucel
may enhance the adverse effects of bone marrow suppression
may enhance the adverse effects of bone marrow suppression
may enhance the adverse effects of bone marrow suppression
Increased risk of myelosuppressive effects.
Increased risk of myelosuppressive effects.
Increased risk of myelosuppressive effects
Increased risk of myelosuppressive effects
Pharmacodynamic synergism may lead to toxicity of immunosuppressant and myelosupressant effects
increase the therapeutic effects of busulfan by inhibiting metabolism
increase the therapeutic effects of busulfan by inhibiting metabolism
increase the therapeutic effects of busulfan by inhibiting metabolism
may enhance the concentration of serum when combined with busulfan
By synergism effects, the toxicity of the other drug increases.
when both drugs combine the risk of both drug increases the toxicity of other by synergism.
both drug toxicity increases by synergism action
when thiotepa and busulfan combine, the toxicity of both drugs increases by synergism
when both the drugs are combined, the risk or severity of adverse effects increases
when both drugs are combined, the risk or severity of adverse effects increases
it may enhance the serum concentration of busulfan
may increase the hepatotoxic effect of acetaminophen
decreases metabolism of busulfan and increases therapeutic effects
Inhibits the CYP3A4 metabolism of busulfan and increases the effect.
It may reduce the toxic effects of busulfan. (pharmacodynamic synergism)
It may reduce the toxic effects of busulfan. (pharmacodynamic synergism)
1 % to 10 %
Category N: There is no data available for the drug under this category
Busulfan is used for the treatment of chronic myelogenous leukemia as far. As the drug does not cure the disease but helps control the complications to improve the quality of life.
The medication is generally taken orally with or without meals once a day.
As the drug shows transdermal and intrapleural absorption, pregnant women must not inhale the dust of the tablets or take the medication.
The side effects may include skin darkening and dry mouth, which may also worsen.
Busulfan may also cause other types of cancer like acute leukemia.
To check on a missed dose, you must take the amount as soon as you remember and should not double the dose if the skipped dose is near the next dose.
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