carbaspirin calcium

Action and Spectrum

Actions and Spectrum: 

Actions: 

They also possess antipyretic, analgesic, and platelet-inhibitory properties, in addition to their anti-inflammatory properties. By inhibiting cyclooxygenase, which changes arachidonic acid into cyclic endoperoxides, which are precursors of prostaglandins, they prevent the formation of prostaglandins. Their antipyretic, analgesic, and platelet-inhibitory activities are due to inhibition of prostaglandin synthesis; their anti-inflammatory properties may be attributed to other mechanisms. 

Spectrum: 

Carbasalate Calcium, also called Carbaspirin Calcium USP BP EP, is a drug that acts as a platelet aggregation inhibitor in addition to being an analgesic, anti-inflammatory, and antipyretic. This substance is a chelate that is created when urea and calcium acetylsalicylate, the calcium version of aspirin, are combined. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Ototoxicity 

Tinnitus 

Black Box Warning

Black Box Warning: 

It is generally not recommended to administer Carbaspirin calcium to children due to the risk of Reye’s syndrome. 

There’s a chance that this medicine will cause gastrointestinal bleeding. Frequent use of tobacco products and alcohol, especially in combination with this medicine, may increase the risk of this side effect. It is best to cut back on alcohol consumption and give up smoking. For more details, speak with your chemist or doctor.

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Allergic to NSAIDS 

Cautions 

• Renal impairment 
• Bleeding disorders 
• Clotting disorders 
• GI disorders 
• Gout 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category.

Pharmacology

Pharmacology: 

Carbaspirin Calcium is used to treat rheumatism, rheumatoid arthritis, menstrual discomfort, fever,  toothache, headache, neuralgia, thrombosis, myocardial infarction, and other conditions. 

Pharmacodynamics: 

Carbaspirin Calcium, categorized as a nonsteroidal anti-inflammatory drug, stands out within its class due to its unique mechanism of irreversible inhibition of both COX-2 and COX-1 activity. This inhibition is achieved by acetylating serine residues (Ser516 and Ser529, respectively) located in the arachidonic acid-binding channel, leading to the suppression of prostaglandin synthesis and a subsequent reduction in the inflammatory response. The medication finds application, either independently or in conjunction with other compounds, for addressing conditions such as headache and pain. Moreover, it is utilized to diminish the risk of stroke and heart attacks in patients dealing with brain ischemia and cardiovascular diseases. 

Pharmacokinetics: 

Absorption 

Following the oral administration of carbasalate calcium in various animal studies, the peak plasma concentrations (C(max)) for SA, ASA, and GA were achieved at 2.00, 0.170, and 2.00 hours, respectively, with values of 42.6 ± 4.62, 8.88 ± 1.31, and 10.1 ± 2.16 μg/mL.  

Distribution 

N/A 

Metabolism 

In summary, a validated analytical method for quantifying ASA, SA, and GA in the plasma of broilers was developed. In broilers, carbasalate calcium undergoes rapid metabolism, with ASA being swiftly converted to SA, and one of the metabolites of SA is GA. 

Elimination and Excretion 

The terminal half-life (t(1/2λz)) for SA, ASA, and GA was 23.7 ± 17.1, 11.2 ± 8.04, and 28.6 ± 4.90 hours, respectively.

Adminstartion

Administration: 

Usually taken orally, carbaspirin calcium can be used either on its own or in conjunction with other drugs. The exact medical problem being treated determines the recommended dosage. The healthcare provider determines the normal dose for inflammation and pain alleviation based on criteria specific to each patient. It is important to stick to the healthcare provider’s instructions and the recommended regimen. Meals may or may not be consumed during administration. For specific advice on dosage, timing, and any possible interactions with other medications they may be taking, patients are recommended to speak with their healthcare professional. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: carbaspirin calcium 

Pronounced: Car-ba-sal-ate Cal-see-um 

Why do we use carbaspirin calcium? 

Carbasalate Calcium, another name for carbaspirin calcium, is utilized for its anti-inflammatory, analgesic, and antipyretic qualities. It is classified as a platelet aggregation inhibitor and is a member of the non-steroidal anti-inflammatory drug (NSAID) class of medications. The drug is frequently used to treat inflammation, lower fever, and relieve discomfort. It is also helpful in certain cardiovascular situations where preventing excessive blood clotting is advantageous due to its inhibitory effect on platelet aggregation. Based on its pharmacological effects, carbaspirin calcium, which is essentially a chelate made of urea and calcium acetylsalicylate (the calcium salt of aspirin), is used for a variety of medicinal purposes.