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Brand Name :
Restanza
Synonyms :
cethromycin
Class :
Antibiotics/ Macrolide
Brand Name :
Restanza
Synonyms :
cethromycin
Class :
Antibiotics/ Macrolide
Adult dosing
CAP (Community-acquired pneumonia)
Indicated as prophylactic treatment of inhalation anthrax, tularemia caused by Francisella tularensis, and plague caused by Yersinia pestis
It is indicated as prophylactic treatment of inhalation anthrax, tularemia caused by Francisella tularensis, and plague caused by Yersinia pestis
Safety and efficacy study is not available
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the serum levels of cethromycin may be elevated
the rate of metabolism of cethromyucin may be increased
the serum levels of abemaciclib may be increased
the serum levels of cethromycin may be increased
the serum levels of acalabrutinib may be increased
the serum levels of acenocoumarol may be elevated
the rate of metabolism of cethromycin may be increased
the serum levels of afatinib may be increased
the rate of metabolism of albendazole may be reduced
the serum levels of alectinib may be increased
the serum levels of alfentanil may be increased
the rate of metabolism of alfuzosin may be reduced
the serum levels of alpelisib may be increased
Actions and spectrum:
Respiratory infections can occur by several strains of bacteria that require the cautious choice of the treatment as well as the use of the effective antibiotics to eliminate a broad range of potential pathogens. Cethromycin binds to the 50S subunit of ribosomes, thereby inhibiting the synthesis of bacterial proteins. In addition, it can also bind to the ribosomal intermediates of the ribosome biogenesis that again stops the 70S bacterial ribosome from forming and so functionalization does not occur. Since the sequence and structure of ribosomes among the species are similar, cethromycin shows broad activity over several Gram-positive, Gram-negative bacteria, and atypical bacteria.
Adverse reactions
Nausea
Vomiting
Flushing
Bradycardia
Diplopia
Thrombocytosis
Myasthenia gravis
Abnormal LFTs
Vertigo blurred vision
Black box warning
Not listed
Contraindications/Caution
Hypersensitivity
Loose stools
Pregnancy & breastfeeding:
Pregnancy consideration:
Safety and efficacy study is not established
Breastfeeding warnings:
The data about the excretion of cethromycin into human milk is not known
Pregnancy category:
Pharmacology:
Cethromycin is a macrolide antibiotic and a ketolide derivative of erythromycin A containing O-6-linked aromatic ring system and 11, 12-carbmate group.
Pharmacodynamics:
Cethromycin inevitably binds to the 50S subunit of the ribosome of the bacterial cell, thus preventing both the process of ribosome synthesis and the synthesis of bacterial proteins. Adverse effects, such as diarrhea, nausea, vomiting, and headache, may be caused by the inhibition of molecules in mammalian cells that are not the target.
Pharmacokinetics:
Absorption
Cmax of cethromycin is 140mg/L
Distribution
The volume of distribution of cethromycin is found to be 940L
86.7 to 95.6% of cethromycin is found to be bound to plasma proteins
Metabolism
It is known to undergo hepatic metabolism mediated by CYP3A4
Elimination and excretion
Primarily, cethromycin is excreted through the biliary route. 35.7% of unchanged drugs are eliminated through feces
Half-life:
3.6 hours
Administration:
To be administered as advised by the physician
Patient information leaflet
Generic Name: cethromycin
Why do we use cethromycin?
Cethromycin is a ketolide antibiotic used in the treatment of infections because of gram+ve bacteria such as Chlamydia pneumoniae, Clostridium perfringens, H.influenzae, Mycoplasma pneumoniae, Neisseria etc. It is indicated in treating pneumonia.
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