Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Restanza
Synonyms :
cethromycin
Class :
Antibiotics/ Macrolide
Brand Name :
Restanza
Synonyms :
cethromycin
Class :
Antibiotics/ Macrolide
Adult dosingÂ
CAP (Community-acquired pneumonia)Â
Indicated as prophylactic treatment of inhalation anthrax, tularemia caused by Francisella tularensis, and plague caused by Yersinia pestisÂ
It is indicated as prophylactic treatment of inhalation anthrax, tularemia caused by Francisella tularensis, and plague caused by Yersinia pestis
Safety and efficacy study is not available Â
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the effects on QT prolongation may be increased
the serum levels of cethromycin may be elevated
the rate of metabolism of cethromyucin may be increased
the serum levels of abemaciclib may be increased
the serum levels of cethromycin may be increased
the serum levels of acalabrutinib may be increased
the serum levels of acenocoumarol may be elevated
the rate of metabolism of cethromycin may be increased
the serum levels of afatinib may be increased
the rate of metabolism of albendazole may be reduced
the serum levels of alectinib may be increased
the serum levels of alfentanil may be increased
the rate of metabolism of alfuzosin may be reduced
the serum levels of alpelisib may be increased
Actions and spectrum:Â
Respiratory infections can occur by several strains of bacteria that require the cautious choice of the treatment as well as the use of the effective antibiotics to eliminate a broad range of potential pathogens. Cethromycin binds to the 50S subunit of ribosomes, thereby inhibiting the synthesis of bacterial proteins. In addition, it can also bind to the ribosomal intermediates of the ribosome biogenesis that again stops the 70S bacterial ribosome from forming and so functionalization does not occur. Since the sequence and structure of ribosomes among the species are similar, cethromycin shows broad activity over several Gram-positive, Gram-negative bacteria, and atypical bacteria.Â
Adverse reactionsÂ
NauseaÂ
VomitingÂ
FlushingÂ
BradycardiaÂ
Diplopia Â
ThrombocytosisÂ
Myasthenia gravisÂ
Abnormal LFTsÂ
Vertigo blurred visionÂ
Black box warningÂ
Not listedÂ
Contraindications/CautionÂ
HypersensitivityÂ
Loose stoolsÂ
Pregnancy & breastfeeding:Â
Pregnancy consideration:Â
Safety and efficacy study is not establishedÂ
Breastfeeding warnings:Â
The data about the excretion of cethromycin into human milk is not knownÂ
Pregnancy category:Â
Pharmacology:Â
Cethromycin is a macrolide antibiotic and a ketolide derivative of erythromycin A containing O-6-linked aromatic ring system and 11, 12-carbmate group.Â
Pharmacodynamics:Â
Cethromycin inevitably binds to the 50S subunit of the ribosome of the bacterial cell, thus preventing both the process of ribosome synthesis and the synthesis of bacterial proteins. Adverse effects, such as diarrhea, nausea, vomiting, and headache, may be caused by the inhibition of molecules in mammalian cells that are not the target.Â
Pharmacokinetics:Â
AbsorptionÂ
Cmax of cethromycin is 140mg/LÂ
DistributionÂ
The volume of distribution of cethromycin is found to be 940LÂ
86.7 to 95.6% of cethromycin is found to be bound to plasma proteinsÂ
MetabolismÂ
It is known to undergo hepatic metabolism mediated by CYP3A4Â
Elimination and excretionÂ
Primarily, cethromycin is excreted through the biliary route. 35.7% of unchanged drugs are eliminated through fecesÂ
Half-life:Â
3.6 hoursÂ
Administration:Â
To be administered as advised by the physicianÂ
Patient information leafletÂ
Generic Name: cethromycinÂ
Why do we use cethromycin?Â
Cethromycin is a ketolide antibiotic used in the treatment of infections because of gram+ve bacteria such as Chlamydia pneumoniae, Clostridium perfringens, H.influenzae, Mycoplasma pneumoniae, Neisseria etc. It is indicated in treating pneumonia.Â
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