Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Cholbam
Synonyms :
cholic acid
Class :
Bile Acid Replacements
Brand Name :
Cholbam
Synonyms :
cholic acid
Class :
Bile Acid Replacements
Dosage Forms & StrengthsÂ
CapsuleÂ
250mgÂ
50mgÂ
Disorders Due To Bile Acid SynthesisÂ
Indicated for Disorders due to Bile Acid Synthesis
10-15 mg/kg every day orally or in divided two times a day
Peroxisomal Disorder
10-15 mg/kg every day orally or in divided two times a day
Note:
For the Familial hypertriglyceridemia require a 10% enhancement in the recommended dose to account for losses because of its malabsorption; 11-17 mg/kg every day orally or in divided two times a day
Dosage Forms & StrengthsÂ
CapsuleÂ
250mgÂ
50mgÂ
Disorders Due To Bile Acid SynthesisÂ
Indicated for Disorders due to Bile Acid Synthesis
Age >3 weeks
10-15 mg/kg every day orally or in divided two times a day
Age <3 weeks
Safety and efficacy not established
Peroxisomal Disorder
Age >3 weeks
10-15 mg/kg every day orally or in divided two times a day
Age <3 weeks
Safety and efficacy not established
Note:
For the Familial hypertriglyceridemia require a 10% enhancement in the recommended dose to account for losses because of its malabsorption; 11-17 mg/kg every day orally or in divided two times a day
Refer to adult dosingÂ
may diminish the serum concentration of Antacids
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
When cholic acid is used together with ouabain, this leads to reduction in cholic acid excretion
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may diminish the effect when combined with cholic acid by drug binding in the gastrointestinal tract
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may diminish the effect when combined with cholic acid by drug binding in the gastrointestinal tract
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
It may enhance toxicity when combined with cholic acid by diminishing the elimination
One of the main actions of cholic acid is to aid in the digestion and absorption of dietary fats. It acts as a natural detergent emulsifying large fat globule into smaller droplets by increasing the surface area available for digestive enzymes.
Frequency defined
1-10%Â
Malaise (1%)
Diarrhea (2%)
Reflux esophagitis (1%)
Intestinal polyp (1%)
Jaundice (1%)
Abdominal pain (1%)
Nausea (1%)
Peripheral neuropathy (1%)
Skin lesion (1%)
Urinary tract infection (1%)
NoneÂ
ContraindicationÂ
Hypersensitivity or Allergy
Biliary Tract Obstruction
Acute Pancreatitis
Liver Disease
Pregnancy and Breastfeeding
CautionÂ
Gallbladder Function
Gastrointestinal Disorders
Renal Impairment
Pregnancy consideration:Â Â
US FDA pregnancy category: Not assigned.
Lactation:  Â
Excreted into human milk: Not known.
Pregnancy Categories:Â Â Â Â Â Â Â
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
Pharmacodynamics:
Cholic acid acts like a detergent in the gut, solubilizing diets fats and enhancing their digestion by pancreatic lipases. This improves on the absorption of fatty acids and cholesterol.
It is involved in the structure of mixed micelles that have a vital role in solubilization and lipid absorption. Micelles are used for the transport of fat-soluble vitamins (A, D, E, K) and other lipids from the intestinal lumen through the mucosa.
Pharmacokinetics:
Absorption:
Cholic acid is well absorbed in gastrointestinal tract.
Distribution:
It is extensively bound to plasma proteins like albumin.
Metabolism:
It undergoes bile acid metabolism in liver.
Elimination and excretion:
Excreted through bile into the intestine, where it helps in emulsification and absorption of fats.
Administration:Â
Cholic acid taken under oral route as capsules or tablets. The dosage given to patients under cholic acid depends on the age, weight, state or health, and reaction to the medication.
Patient information leaflet
Generic Name: cholic acid
Pronounced: [ KOE-lik-AS-id ]
Why do we use cholic acid?
Cholic acid is recommended for patients with specific disease of bile acid synthesis, which are inherited metabolic disorders of liver that interfere with bile acids production.
It may be used for the PBC, a chronic liver disease that develops through inflammation and gradual obliteration of the bile ducts in the liver. Cholic acid is a type of bile acid that increases fat- and fat-soluble vitamins digestion. It is also used lipid digestion and several liver diseases as therapeutic agents.
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