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Brand Name :
Trilisate, Tricosal
Synonyms :
choline salicylate/magnesium salicylate; Choline magnesium trisalicylate
Class :
Analgesic, Anti-inflammatory, Antipyretic, NSAIDs, Salicylates
Brand Name :
Trilisate, Tricosal
Synonyms :
choline salicylate/magnesium salicylate; Choline magnesium trisalicylate
Class :
Analgesic, Anti-inflammatory, Antipyretic, NSAIDs, Salicylates
Dosage Forms & Strengths Solution (oral)
500 mg/5 mL
Tablet
500 mg
750 mg
1000 mg
Dosage Forms & Strengths
Solution (oral)
500 mg/5 mL
Tablet
500 mg
750 mg
1000 mg
Dosage Forms & Strengths
Solution (oral)
500 mg/5 mL
Tablet
500 mg
750 mg
1000 mg
Actions and Spectrum:
Actions:
Choline magnesium salicylate, a salicylate NSAID type, handles pain, body fever, and inflammation effectively. Diflunisal, aspirin, and salsalate to reduce levels of prostaglandin. They block cyclooxygenase enzyme, resulting in decreased pain, inflammation, and fever.
Spectrum:
Choline salicylate and magnesium salicylate work together. Their teamwork deals with pain, swelling, and fever issues. They help in many conditions where these problems occur.
Prostaglandins are substances made in the body. The salicylate combination stops these substances from forming. This action provides pain relief, lowers inflammation, and reduces fever.
Frequency not defined
Hearing loss, tinnitus
Vomiting material that looks like coffee grounds
Stomach pain
Angioedema
Headache
Dermatologic problems, urticaria
Constipation
Ulceration/GI pain/bleeding
Bloody vomit
Lack of energy
Dizziness
Red blood in stools
Upset stomach
Premature hemolysis
Renal damage
Pulmonary edema (salicylate-induced/noncardiogenic)
Black and tarry stools
CNS alteration
Heartburn
Lightheadedness
Hearing loss
Vomiting
Hepatotoxicity
Diarrhea
Black Box Warning:
This medicine may cause dizziness. Don’t drive or operate machinery when taking it. It’s not suitable for kids or teens. Avoid alcohol consumption, too. These are precautions to ensure safe usage and reduce potential side effects in vulnerable groups.
Never gives aspirin or salicylates to a child or teen with fever and viral symptoms like chickenpox or flu without checking with their doctor first. This can lead to Reye’s syndrome: a severe illness linked to salicylates during viral infections. Some children need regular salicylates for conditions such as arthritis; the doctor may pause this temporarily during viral fever. Discuss this plan ahead in case your child falls ill. Even without viral infections, children can be sensitive to salicylates, especially with fever or significant fluid loss, increasing the risk of side effects during treatment.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
Pregnancy category: C & D
Pregnancy Category: C; May become Category D if used for a long time or near delivery.
Breastfeeding warnings:
Found in breast milk; may negatively affect the nursing baby.
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Cyclooxygenase enzyme comes in two types: 1 and 2. This medication blocks these enzymes. It lowers prostaglandin production – hormone-like substances causing inflammation and pain. The inflammatory response reduces, providing pain and swelling relief.
Pharmacodynamics:
Trisalicylate-choline is a special anti-inflammatory medication. Unlike other similar drugs, it doesn’t affect platelet clumping. This makes it useful for patients who need anti-inflammatory treatment but can’t risk changes in how platelets work. The medication reduces inflammation and pain effectively. It achieves this without interfering with platelet function due to its unique composition of choline salicylate and magnesium salicylate.
Pharmacokinetics:
Absorption
The drug starts working fast, between 5-30 minutes after taking it by mouth or 1-2 hours if given rectally. Its highest concentration in the bloodstream happens at 2 hours when taken orally but takes 4-5 hours when given rectally.
Distribution
The protein binds to the medicine much like 90-95% when levels are less than 100 mcg/mL. At 100-400 mcg/mL, the bonding drops to 70-85%. Above that, bonding decreases even more, down to just 25-60%.
The medicine spreads out through 0.15-0.2 L for each kg of body weight. This is known as the volume of distribution.
Metabolism
Substances get broken down mostly in the liver. A process involving tiny enzyme systems makes this happens. Active substances form through this enzyme activity. These formed substances can affect the body in different ways.
Elimination and Excretion
Half-life lasts 2-3 hours after small doses. Large doses bring 15-30 hour half-lives. Oral dosing effects last 3-6 hours. Rectal routes last over 7 hours.
Clearance occurs over 24-72 hours. Most excretion happens in urine, with 80-100% eliminated. Sweat, saliva, and feces also remove trace amounts.
Administration:
Choline and magnesium salicylates blend in some oral solutions, with varying dosages between products. Patients should use the recommended dose and device, following their healthcare provider’s instructions. The solution gets taken orally, either directly or mixed with water as directed. Adhering to prescribed doses and seeking guidance for concerns is crucial. Details and guidelines vary among products with this combination.
Precisely follow your doctor’s dosage instructions, not deviating in amount or duration. Consume choline magnesium tri- salicylate with food, milk, or antacid if stomach discomfort occurs. Consider bedtime dosing, waiting at least 30 minutes before lying down. Use a specific dose-measuring tool or consult a pharmacist if the liquid form is unavailable. Enhance taste by mixing liquid with a small amount of fruit juice, but drink immediately after stirring. Symptoms may take up to 3 weeks to improve, and consistent treatment plan adherence vital. Notify the doctor if there is no improvement after two weeks. Exercise caution during medical tests and inform providers about usage. For planned surgery, inform the surgeon in advance; temporary cessation is possibly required—Store at room temperature, protecting from moisture and heat.
Patient information leaflet
Generic Name: choline salicylate/magnesium salicylate
Pronounced: KOH-leen sa-luh-sil-ate/mag-NEE-zee-um sa-luh-sil-ate
Why do we use choline salicylate/magnesium salicylate?
Choline salicylate and magnesium salicylate are anti-inflammatory medicines. They work by stopping swelling and pain. These NSAIDs come in liquid or cream. The cream reduces joint pain. The liquid helps mild pains like headaches or muscle aches. Doctors suggest how to use these medicines safely. The right type and strength depends on your symptoms and health.
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