Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Nupercaine, Faktu, Cincain, Sovcaine
Synonyms :
cinchocaine, Cinchocainum, Cincocainio, Dibucaine
Class :
Neuropsychiatric agent, Anesthetics, Local anesthetic, Amide type local anesthetic
Brand Name :
Nupercaine, Faktu, Cincain, Sovcaine
Synonyms :
cinchocaine, Cinchocainum, Cincocainio, Dibucaine
Class :
Neuropsychiatric agent, Anesthetics, Local anesthetic, Amide type local anesthetic
Dosage Forms & StrengthsÂ
5 gÂ
10 gÂ
1% ointmentÂ
It is indicated for surface anesthesia
The recommended dose is 1 % in ointment and cream
Dose Adjustments
Limited data is available
When used in conjunction with hydrocortisone as a 0.05% w/w ointment: After every feces, as well as in the morning and evening, apply to the affected area
When used as a suppository with 5 mg per unit (in addition to hydrocortisone): Place one suppository after every feces and in the morning and evening
Dose Adjustments
Limited data is available
It is indicated for surface anesthesia
The recommended dose is 1 % in ointment and cream
Dose Adjustments
Limited data is available
When used in conjunction with hydrocortisone as a 0.05% w/w ointment: After every feces, as well as in the morning and evening, apply to the affected area
When used as a suppository with 5 mg per unit (in addition to hydrocortisone): Place one suppository after every feces and in the morning and evening
Dose Adjustments
Limited data is available
Dosage Forms & StrengthsÂ
TopicalÂ
5 gÂ
10 gÂ
1% ointmentÂ
It is indicated for pain and itching
Safety and efficacy are not seen in pediatrics below 2 years
Children two years of age and up: Apply the ointment as needed, up to three or four times a day
7.5 g is the maximum amount that can be used in a 24-hour period
It is indicated for pain and itching
Safety and efficacy are not seen in pediatrics below 2 years
Children two years of age and up: Apply the ointment as needed, up to three or four times a day
7.5 g is the maximum amount that can be used in a 24-hour period
Refer to the adult dosingÂ
cinchocaine: it may increase the risk of methemoglobinemia associated agents
cinchocaine: it may increase the risk of methemoglobinemia associated agents
cinchocaine: it may increase the risk of methemoglobinemia associated agents
cinchocaine: it may increase the risk of methemoglobinemia associated agents
cinchocaine: it may increase the risk of methemoglobinemia associated agents
The potential for methemoglobinemia to occur or its seriousness may be enhanced when mepartricin is used together with cinchocaine
When cyclacillin is used together with cinchocaine, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with cinchocaine, this leads to increased risk or seriousness of methemoglobinemia
When cinchocaine is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with cinchocaine, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with cinchocaine, this leads to enhanced risk or seriousness of CNS depression
the risk of methemoglobinemia may be increased when abiraterone is combined with cinchocaine
cinchocaine has the potential to amplify the bradycardic activities of acebutolol
the risk of adverse effects may be increased when cinchocaine is combined with acetylcholine
When cinchocaine is used in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
cinchocaine: it may increase the risk of methemoglobinemia with pheneticillin
cinchocaine: it may increase the risk of adverse with arecoline
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia can be increased
the combined use of cinchocaine and abemaciclib results in a greater risk of methemoglobinemia
the risk of methemoglobinemia can be elevated when acetaminophen is combined with cinchocaine
when cinchocaine is combined with acetazolamide, there is an increased risk or severity of methemoglobinemia associated with the latter
the risk of methemoglobinemia may be heightened when acetic acid is combined with cinchocaine
there is a potential for increased risk or severity of CNS depression when cinchocaine is combined with acetophenazine
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
the risk of methemoglobinemia may be increased
When cinchocaine is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Actions and Spectrum:Â
Actions:Â
It works by numbing the region where it is applied, which prevents pain from being felt. Additionally, it relieves back passage tightness and reduces inflammation and swelling in the veins of the anus and rectum. Because of its significant neurotoxicity, the US Food and Drug Administration has discontinued using it as a spinal anesthetic.Â
Spectrum:Â
Strong amino amide local anesthetic cinchocaine is given to reduce pain and irritation from poison ivy, mild burns, sunburns, scrapes, scratches, and insect bites. It is also used in ear drop solutions.Â
It is also used to treat hemorrhoids (piles), which cause pain and itching in the rectal area. It is a part of the veterinary medication known as Somulose, which is used to put horses and cattle to sleep.Â
Frequency not definedÂ
NervousnessÂ
DizzinessÂ
RestlessnessÂ
VomitingÂ
ConvulsionsÂ
Blurred visionÂ
ParesthesiasÂ
ExcitementÂ
HypotensionÂ
Muscle twitchingÂ
BradycardiaÂ
TremorsÂ
ArrythmiasÂ
NauseaÂ
TinnitusÂ
Black Box Warning:Â
 If you experience any allergic reaction to the medication, such as rash, blistering or peeling skin, or irritation, please stop taking it or let your doctor know.Â
Avoid rubbing your eye after using the medication. Any dosage of the medication taken by accident, especially by young children, has the potential to be dangerous and even lethal.Â
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy consideration:Â Â
No data is available regarding the administration of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of drug in breast milk.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
One type of amide local anesthetic is cinchocaine. Due to its blocking ability to of sodium channels, it is one of the most powerful and dangerous long-acting local anesthetics. Demonstrated to be a calpain activator that causes leukemia cells to undergo apoptosis as well as platelet apoptosis. You can use this compound as a reference.Â
Pharmacodynamics:Â
Cinchocaine inhibits or stops the conduction of nerve impulses close to the administration site. It also has a membrane-stabilizing effect because it reduces the nerve cell’s permeability to sodium ions. Â
Pharmacokinetics:Â
AbsorptionÂ
The time to achieve peak effect is 2-4 hoursÂ
DistributionÂ
N/AÂ
MetabolismÂ
HepaticÂ
Elimination and ExcretionÂ
N/AÂ
Administration:Â
Applying enough ointment will ensure that the affected region is completely covered.Â
Wash the skin with soap and water, then rinse and pat dry before applying.Â
Apply it to the exterior of the rectum four times a day or after every bowel movement if you have hemorrhoids.Â
Patient information leafletÂ
Generic Name: cinchocaineÂ
Pronounced: SIN-koh-kaneÂ
Why do we use cinchocaine?Â
Cinchocaine serves dual purposes as a local anesthetic and an antiarrhythmic medication. Primarily utilized to temporarily numb or alleviate pain and discomfort during various medical procedures, its applications extend to different domains of healthcare. One everyday use involves its incorporation into topical creams or ointments designed to numb the skin or mucous membranes.
This proves beneficial for minor surgical procedures, medical examinations, and situations necessitating temporary local anesthesia. Additionally, cinchocaine finds application in the treatment of hemorrhoids, often combined with other ingredients in creams or ointments to relieve pain and discomfort associated with this condition.
By numbing the affected area, it contributes to the alleviation of itching and pain. In less frequent instances, cinchocaine serves as an antiarrhythmic agent, assisting in the regulation of irregular heart rhythms. However, its use for this purpose is not as widespread as other medications with similar properties.Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
