Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
CIZINATE
Synonyms :
cinnarizine/dimenhydrinate
Class :
Histamine receptor antagonist, Histamine receptor H1 antagonist, Antivertigo
Brand Name :
CIZINATE
Synonyms :
cinnarizine/dimenhydrinate
Class :
Histamine receptor antagonist, Histamine receptor H1 antagonist, Antivertigo
Dosage forms and strengthsÂ
Oral tablets (cinnarizine/dimenhydrinate)Â
20 mg/40Â
Not indicatedÂ
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this combination may raise the efficacy/effects of tricyclic antidepressants
acetaminophen and phenyltoloxamine
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
dexchlorpheniramine, dextromethorphan, and phenylephrine
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
Actions and Spectrum: Â
Actions: Â
Cinnarizine widens inner ear blood vessels, aiding circulation, while Dimenhydrinate relieves vertigo by blocking histamine.Â
Spectrum: Â
Cinnarizine + Dimenhydrinate targets vertigo symptoms, providing relief for various causes. It addresses dizziness and related symptoms for diverse types of vertigo.Â
Frequency not defined Â
Aplastic anemia Â
Headache Â
Leucopenia Â
Thrombopenia Â
Visual disorders Â
Paresthesia Â
Tinnitus Â
Amnesia Â
Convulsions Â
Dry mouth Â
Black Box Warning: Â
This combination might make you sleepy and affect driving or machinery operation; avoid these activities if you feel drowsy, especially at the start of treatment.
Contraindication/Caution: Â
Contraindications Â
Hypersensitivity Â
Severe kidney disease Â
Severe liver disease Â
Substance abuse Â
Urethroprostatic disorders Â
Cautions Â
Hypotension Â
Gastric irritation Â
Anticholinergic therapy Â
Prostatic hypertrophy Â
Pyloro-duodenal obstruction Â
Drug interactions Â
Pregnancy and Breastfeeding Â
Pregnancy/Lactation:Â
Pregnancy consideration:  Â
No data is available regarding the administration of the drug during pregnancy. Â
Breastfeeding warnings:  Â
No data is available regarding the excretion of drug in breast milk. Â
Pregnancy category: Â
Category A: Well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. Â
<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    Â
Category N: No data is available for the drug under this category. Â
Pharmacology: Â
The combination drug inhibits the action of histamine and increases microcirculation, which is beneficial in treating dizziness and vertigo.Â
Pharmacodynamics: Â
The combination drugs work through different mechanisms cinnarizine acts as a sedative on the peripheral vestibular system, whereas dimenhydrinate acts as an antihistamine that targets the central vestibular system to treat nausea & vertigo.Â
Pharmacokinetics: Â
Absorption Â
Peak effect can be reached between 2 to 4 hours (both). Dimenhydrinate rapidly releases its diphenhydramine component after oral ingestion. Â
Metabolism Â
Diphenhydramine and Cinnarizine undergo extensive liver metabolism. Â
Excretion and EliminationÂ
Cinnarizine is mainly excreted in feces (40 to 60%), while urine eliminates a smaller portion of metabolites with glucuronic acid. Diphenhydramine is primarily eliminated via urine, with its primary metabolite being diphenylmethoxy acetic acid (40 to 60%).Â
Administration: Â
The combination drug is taken orally.Â
Patient information leaflet Â
Generic Name: cinnarizine/dimenhydrinate Â
Pronounced: sin-uh-RIZ-een/dye-men-HYE-drih-nate Â
Why do we use cinnarizine/dimenhydrinate? Â
The combination drug is used in cases of motion sickness which is a symptom of travel in planes and cars. It is also proving to be beneficial in symptoms of vomiting, nausea & dizziness. It is used in the treatment of vertigo.Â
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