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Brand Name :
CIZINATE
Synonyms :
cinnarizine/dimenhydrinate
Class :
Histamine receptor antagonist, Histamine receptor H1 antagonist, Antivertigo
Brand Name :
CIZINATE
Synonyms :
cinnarizine/dimenhydrinate
Class :
Histamine receptor antagonist, Histamine receptor H1 antagonist, Antivertigo
Dosage forms and strengths
Oral tablets (cinnarizine/dimenhydrinate)
20 mg/40
Not indicated
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this is combination is contraindicated in patients with cardiovascular diosrdrs who are on antiarrhythmic drugs
this combination may raise the efficacy/effects of tricyclic antidepressants
acetaminophen and phenyltoloxamine
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
this combination will make you feel sleepy or tired when Analgesics used in combination
dexchlorpheniramine, dextromethorphan, and phenylephrine
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Antihistamines used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when MAOIs used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
this combination will make you feel sleepy or tired when Tranquillisers used in combination
Actions and Spectrum:
Actions:
Cinnarizine widens inner ear blood vessels, aiding circulation, while Dimenhydrinate relieves vertigo by blocking histamine.
Spectrum:
Cinnarizine + Dimenhydrinate targets vertigo symptoms, providing relief for various causes. It addresses dizziness and related symptoms for diverse types of vertigo.
Frequency not defined
Aplastic anemia
Headache
Leucopenia
Thrombopenia
Visual disorders
Paresthesia
Tinnitus
Amnesia
Convulsions
Dry mouth
Black Box Warning:
This combination might make you sleepy and affect driving or machinery operation; avoid these activities if you feel drowsy, especially at the start of treatment.
Contraindication/Caution:
Contraindications
Hypersensitivity
Severe kidney disease
Severe liver disease
Substance abuse
Urethroprostatic disorders
Cautions
Hypotension
Gastric irritation
Anticholinergic therapy
Prostatic hypertrophy
Pyloro-duodenal obstruction
Drug interactions
Pregnancy and Breastfeeding
Pregnancy/Lactation:
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: Well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
The combination drug inhibits the action of histamine and increases microcirculation, which is beneficial in treating dizziness and vertigo.
Pharmacodynamics:
The combination drugs work through different mechanisms cinnarizine acts as a sedative on the peripheral vestibular system, whereas dimenhydrinate acts as an antihistamine that targets the central vestibular system to treat nausea & vertigo.
Pharmacokinetics:
Absorption
Peak effect can be reached between 2 to 4 hours (both). Dimenhydrinate rapidly releases its diphenhydramine component after oral ingestion.
Metabolism
Diphenhydramine and Cinnarizine undergo extensive liver metabolism.
Excretion and Elimination
Cinnarizine is mainly excreted in feces (40 to 60%), while urine eliminates a smaller portion of metabolites with glucuronic acid. Diphenhydramine is primarily eliminated via urine, with its primary metabolite being diphenylmethoxy acetic acid (40 to 60%).
Administration:
The combination drug is taken orally.
Patient information leaflet
Generic Name: cinnarizine/dimenhydrinate
Pronounced: sin-uh-RIZ-een/dye-men-HYE-drih-nate
Why do we use cinnarizine/dimenhydrinate?
The combination drug is used in cases of motion sickness which is a symptom of travel in planes and cars. It is also proving to be beneficial in symptoms of vomiting, nausea & dizziness. It is used in the treatment of vertigo.
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