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Brand Name :
N/A
Synonyms :
clomocycline, clomocyclina
Class :
Antibacterial agents
Brand Name :
N/A
Synonyms :
clomocycline, clomocyclina
Class :
Antibacterial agents
Dosage forms and strengths
In vivo, data suggests taking 17mg/kg orally either as one dose or in two doses at six to eight hours duration
The oral administration of 34 mg/kg split in either two or three doses is taken every six hours
In vivo, data suggests taking 17mg/kg orally either as one dose or in two doses at six to eight hours duratio
The oral administration of 34 mg/kg split in either two or three doses is taken every six hours
Not indicated
Refer adult dosing
When clomocycline is used together with ambroxol, this leads to enhanced risk or seriousness of methemoglobinemia
When clomocycline is used together with articaine, this leads to enhanced risk or seriousness of methemoglobinemia
When clomocycline is used together with benzocaine, this leads to enhanced risk or seriousness of methemoglobinemia
When clomocycline is used together with benzyl alcohol, this leads to enhanced risk or seriousness of methemoglobinemia
When clomocycline is used together with bupivacaine, this leads to enhanced risk or seriousness of methemoglobinemia.
When azlocillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of azocillin
When bacampicillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of bacampicillin
When benzylpenicillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of benzylpenicillin
When carindacillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of carindacillin
When cloxacillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of cloxacillin
When cyclacillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of cyclacillin
When flucloxacillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of flucloxacillin
When lactulose is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of lactulose
When meticillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of meticillin
When mezlocillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of mezlocillin
When nafcillin is used together with clomocycline, this leads to a reduction in therapeutic effectiveness of nafcillin
When calcium chloride is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When dienogest is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When desogestrel is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium citrate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium glucoheptonate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium gluconate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium lactate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium levulinate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When calcium phosphate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When diethylstilbestrol is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When drospirenone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When dydrogesterone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When estradiol is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When estradiol benzoate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When estradiol cypionate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When estradiol valerate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When estrone sulfate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When ethinylestradiol is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When etonogestrel is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When levonorgestrel is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When lynestrenol is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When medrogestone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When megestrol acetate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When mestranol is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When mifepristone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When norelgestromin is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When norethisterone is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When norethynodrel is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When norgestimate is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
When norgestrel is used together with clomocycline, this leads to reduction in concentration serum of clomocycline
Actions and Spectrum:
Action:
Clomocycline is an antibiotic. It belongs to the tetracycline class. Clomocycline works by stopping bacterial protein synthesis. It does this by binding to the ribosome in bacteria. This binding prevents aminoacyl-tRNA from attaching to the mRNA-ribosome complex. As a result, the peptide chain can’t add more amino acids. So bacterial growth stops.
Spectrum:
It works on many different bacteria types. Some are gram-positive, others gram-negative. It also fights other organisms like Chlamydia, Mycoplasma, Rickettsiae.
Frequency not defined
Burning sensation
Redness
Dryness
Itching
Black Box Warning:
None
Contraindication/Caution:
Allergy or hypersensitivity
Pregnancy
Liver or kidney disease
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Clomocycline fights bacterial infections. It’s a tetracycline antibiotic. Clomocycline stops bacteria from making proteins, preventing their growth. This antibiotic treats many bacterial infections. It works against gram-positive and gram-negative bacteria. Clomocycline also fights some other germs. Doctors prescribe clomocycline for its broad activity. It’s a helpful treatment option.
Pharmacodynamics:
It works by stopping bacterial protein formation. It attaches to bacterial ribosomes, blocking new amino acids from joining the growing protein chain. This prevents further bacterial growth. It halts the bacteria’s ability to make proteins, a crucial process for its survival and multiplication. With no new proteins created, the bacterial cells can’t divide or increase in number, effectively stunting their proliferation.
Pharmacokinetics:
Absorption
Clomocycline gets absorbed smoothly and quickly after taking it by mouth. Its highest amount in the blood happens between 2 to 4 hours after swallowing.
Distribution
It spreads widely across flesh and essential fluids, even buried in bone tissue. And, it also circulates the central nervous system.
Metabolism
Hepatic metabolism
Excretion and Elimination
The medicine is mostly eliminated by faeces, with urine excreting a lesser amount of the drug.
Administration:
Taking this medicine involves swallowing it.
The doctor or nurse who prescribed this medication must provide exact directions regarding how to properly take it. Following their specific instructions is essential.
Patient information leaflet
Generic Name: clomocycline
Why do we use clomocycline?
Clomocycline is a powerful antibiotic. It fights bacteria that cause many infections. Clomocycline works very well against Propionibacterium acnes, the main germ behind acne. It also treats urinary tract infections from common germs like E. coli and Staph. Moreover, clomocycline helps with gum infections like gingivitis and periodontitis. Impressively, it treats sexually transmitted diseases, including chlamydia and gonorrhea.
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