clotiazepam

Action and Spectrum

Actions and Spectrum 

Clotiazepam acts on the gamma-aminobutyric acid (GABA) receptors in the brain. 

GABA is an inhibitory neurotransmitter, and when it binds to its receptors, it opens chloride channels, leading to an influx of chloride ions.

Drug Interaction

Adverse Reaction

Frequency not defined  

Drowsiness and lightheadedness 

Urinary retention or incontinence 

GI disturbances 

changes in salivation 

Sedation 

Muscle weakness 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known hypersensitivity or allergy to clotiazepam should not use. 

Caution: 

• Clotiazepam should be avoided in individuals with myasthenia gravis. 
• It is contraindicated in individuals with severe respiratory insufficiency. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Clotiazepam possesses muscle relaxant properties, making it effective in reducing muscle spasticity and tension. 

The binding of clotiazepam to the GABA-A receptor enhances the effects of GABA, leading to an increase in the opening frequency of chloride channels.  

Pharmacodynamics 

Clotiazepam’s action is an enhancement of inhibitory neurotransmission in the central nervous system. 

This enhancement leads to a calming effect, resulting in anxiolytic, sedative, and muscle relaxant properties. 

Pharmacokinetics 

Absorption   

Clotiazepam undergoes absorption in the gastrointestinal tract. 

Distribution 

Clotiazepam is distributed throughout the body via the bloodstream. 

Metabolism 

Clotiazepam undergoes metabolism in the liver. 

Elimination and excretion 

Clotiazepam is excreted from the body. 

Adminstartion

Administration 

Clotiazepam is taken orally in the form of tablets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: clotiazepam 

Why do we use clotiazepam? 

Clotiazepam is indicated for the treatment of various anxiety disorders.  

Clotiazepam is used to treat insomnia and it can help individuals fall asleep faster and improve the quality of sleep.