Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Ketesse
Synonyms :
dexketoprofen
Class :
Analgesic, Nonsteroidal Anti-inflammatory Drug
Dosage Forms & StrengthsÂ
Tablet  Â
25 mgÂ
Take a dose of 12.5 mg orally every 4 to 6 hours
Daily dose not more than 75 mg
Not determined Â
Refer to adult dosingÂ
choline magnesium trisalicylate
may have an increasingly adverse effect when combined with dexketoprofen
interaction may increase the serum concentration of methotrexate
dexketoprofen may enhance the risk of adverse effects of Sulfonamides
dexketoprofen may enhance the risk of adverse effects of Sulfonamides
It has the potential to increase the adverse/harmful effects of sulfonamides
It has the potential to increase the adverse/harmful effects of sulfonamides
it may diminish the excretion rate when combined with pentastarch, resulting in an enhanced serum level
It may enhance the risk of nephrotoxicity when combined with phenylbutazone
When dexketoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dexketoprofen is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When dexketoprofen is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cefmenoxime is used together with dexketoprofen, this leads to enhanced risk or seriousness of nephrotoxicity
When dexketoprofen is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
dexketoprofen: they may increase the CNS depressant effect of CNS Depressants
dexketoprofen: they may increase the CNS depressant effect of CNS Depressants
dexketoprofen: they may increase the CNS depressant effect of CNS Depressants
dexketoprofen: they may increase the CNS depressant effect of CNS Depressants
dexketoprofen: they may increase the CNS depressant effect of CNS Depressants
When dexketoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
dexketoprofen leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When dexketoprofen is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When dexketoprofen is used together with difenpiramide, this leads to increased risk or seriousness of adverse events
dexketoprofen: it may increase the risk of gastrointestinal bleeding with risedronic acid
dexketoprofen: it may decrease the therapeutic efficacy of phentolamine
Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of aliskiren
bile Acid Sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents
may enhance the risk or severity of hypertension when combined
dexketoprofen might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
SSRIs increase the antiplatelet effect of NSAIDs
Actions and SpectrumÂ
dexketoprofen works by inhibiting an enzyme called cyclooxygenase (COX), specifically the COX-1 and COX-2 enzymes.Â
By inhibiting COX enzymes, dexketoprofen reduces the production of prostaglandins, leading to decreased inflammation, pain, and fever.  Â
Frequency not defined Â
Glomerular nephritis Â
Acute renal failureÂ
BronchospasmÂ
Worsening of hypertension Â
PalpitationsÂ
VertigoÂ
AnxietyÂ
FlushingÂ
Interstitial nephritisÂ
Renal papillary necrosis Â
Nephrotic syndromeÂ
Fluid retentionÂ
Oedema  Â
Prolonged bleeding timeÂ
NauseaÂ
Abdominal pain Â
Diarrhea Â
GastritisÂ
Constipation Â
Flatulence Â
Dry mouthÂ
VomitingÂ
DyspepsiaÂ
Headache Â
Dizziness Â
SomnolenceÂ
InsomniaÂ
Gastrointestinal bleedingÂ
Black Box WarningÂ
NoneÂ
Contraindication/Caution:Â
Contraindication:Â
Caution:Â
Pregnancy consideration:Â
Pregnancy category: N/AÂ
Lactation: Excretion into human milk is unknown Â
Pregnancy Categories:        Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
Pharmacology Â
dexketoprofen, like other NSAIDs, exerts its effects primarily through the inhibition of cyclooxygenase (COX) enzymes. Â
These enzymes COX-1 and COX-2 are responsible for the conversion of arachidonic acid into prostaglandins.Â
PharmacodynamicsÂ
dexketoprofen’s inhibition of COX-2 results in reduced synthesis of prostaglandins, which are mediators of inflammation. This leads to decreased vasodilation and reduced permeability of blood vessels.Â
PharmacokineticsÂ
Absorption  Â
dexketoprofen is well absorbed after oral administration. Â
DistributionÂ
dexketoprofen has a high distribution volume and it can penetrate various tissues throughout the body. Â
MetabolismÂ
dexketoprofen undergoes metabolism mainly in the liver. Â
Elimination and excretionÂ
dexketoprofen is excreted primarily through the urine. Â
AdministrationÂ
dexketoprofen is often available in the form of oral tablets or capsules.
Patient information leafletÂ
Generic Name: dexketoprofenÂ
Why do we use dexketoprofen?Â
dexketoprofen is frequently used to manage pain after surgical procedures. It can help alleviate pain, reduce inflammation at the surgical site, and improve the comfort during the recovery period. It is effective in providing relief from pain associated with musculoskeletal conditions and in treatment of mild to moderate pain.Â
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