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Brand Name :
N/A
Synonyms :
diflucortolone
Class :
Corticosteroid, Topical
Dosage Forms & Strengths
Topical
1 mg/g
Apply a thin layer into the affected area for 1 to 2 times a day
Administration in thin layers twice daily to the affected area
Administration in thin layers twice daily to the affected area
Dosage Forms & Strengths
Topical
1 mg/g
Administration in thin layers twice daily to the affected area
Refer to adult dosing
diflucortolone: it may decrease the excretion rate of metheglobinemia associated agents
diflucortolone: it may decrease the excretion rate of metheglobinemia associated agents
diflucortolone: it may decrease the excretion rate of metheglobinemia associated agents
diflucortolone: it may decrease the excretion rate of metheglobinemia associated agents
diflucortolone: it may decrease the excretion rate of metheglobinemia associated agents
Actions and Spectrum
diflucortolone reduces inflammation by inhibiting the production of inflammatory mediators. It suppresses the release of pro-inflammatory substances and reduces the migration of inflammatory cells to the site of inflammation.
Frequency not defined
Cardiovascular: Hypertension
Neuromuscular and skeletal: Decreased linear skeletal growth rate, osteoporosis
Endocrine and metabolic: Cushingoid appearance, glycosuria, hyperglycemia, obesity, weight gain, decreased plasma cortisol
Hypersensitivity: Local hypersensitivity reaction
Immunologic: Immunosuppression
Central nervous system: Localized burning, steroid withdrawal syndrome
Infection: Secondary infection
Local: Application site irritation, application site pain
Dermatologic: Acneiform eruption, alopecia, atrophic striae, contact dermatitis, dermatitis, miliaria, perioral dermatitis, pruritus, pustular psoriasis, skin atrophy, skin pain, dyschromia, epidermal thinning, erythema, folliculitis, hair breakage, hypertrichosis
Ophthalmic: Cataract, glaucoma
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
diflucortolone binds to cytoplasmic glucocorticoid receptors, forming a steroid-receptor complex. This complex translocates into the nucleus and binds to specific DNA sequences known as glucocorticoid response elements.
Pharmacodynamics
diflucortolone possesses immunosuppressive effects by inhibiting the function of immune cells, particularly T-lymphocytes. It reduces the migration of immune cells to sites of inflammation and inhibits the release of cytokines.
Pharmacokinetics
Absorption
Systemic absorption of diflucortolone is generally minimal when used topically.
Distribution
diflucortolone distributes throughout the body.
Metabolism
diflucortolone undergoes hepatic metabolism metabolized by the liver through various enzymatic processes.
Elimination and excretion
The metabolites of diflucortolone are primarily excreted in the urine and feces.
Administration
diflucortolone is available in various formulations, including creams, ointments, gels, and lotions for topical use.
Patient information leaflet
Generic Name: diflucortolone
Why do we use diflucortolone?
diflucortolone is used for the treatment of various skin conditions including seborrheic dermatitis (scalp and facial rash), and allergic dermatitis. diflucortolone is also used to relieve inflammation, itching, redness, and other symptoms associated with eczema.
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