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Brand Name :
Tecfidera
Synonyms :
Dimethyl fumarate
Class :
immunomodulators
Brand Name :
Tecfidera
Synonyms :
Dimethyl fumarate
Class :
immunomodulators
Dosage Forms & Strengths
Delayed release capsules
120mg
240mg
Initial dose-120mg orally twice a day
The maintenance dose can increase up to 240mg orally twice a day
Dosage Forms & Strengths
Safety and efficacy not established
Refer adult dosing
measles mumps and rubella vaccine, live
it increases the toxicity of live vaccines
measles, mumps, rubella and varicella vaccine, live
it increases the toxicity of live vaccines
it increases the toxicity of live vaccines
smallpox (vaccinia) vaccine, live
it increases the toxicity of live vaccines
it increases the toxicity of live vaccines
may increase the toxic effect
may increase the toxic effect
measles, mumps, rubella, and varicella vaccine, live (Rx)
may enhance the adverse/toxic effect of vaccines
measles mumps and rubella vaccine, live
may enhance the adverse/toxic effect of vaccines
may enhance the adverse/toxic effect of vaccines
vaccinia immune globulin intravenous (Rx)
may enhance the adverse/toxic effect of vaccines
may enhance the adverse/toxic effect of vaccines
poliovirus vaccine, live, trivalent
may enhance the adverse/toxic effect of vaccines
poliovirus vaccine inactivated
may enhance the adverse/toxic effect of vaccines
measles, mumps, rubella, and varicella vaccine, live (Rx)
may enhance the adverse/toxic effect of vaccines
dimethyl fumarate: they may increase the toxic effect of vaccines
measles, mumps, rubella, and varicella vaccine, live
dimethyl fumarate: they may increase the toxic effect of vaccines
when both drugs are combined, there may be an increased risk of serious infections
when both drugs are combined, there may be an increased risk of serious infections
measles, mumps, rubella and varicella vaccine, live
may increase the toxic effects of each other
may increase the CNS depressant effect of CNS Depressants
it may diminish the excretion rate when combined with quinolones, resulting in an enhanced serum level
it may diminish the excretion rate when combined with quinolones, resulting in an enhanced serum level
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of sedation
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
aspirin, chlorpheniramine, and phenylephrine
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
Frequency defined:
>10%
Abdominal pain
Nausea
Flushing
Diarrhea
1-10%
Pruritis
Albumin in urine
Dyspepsia
Lymphopenia
Vomiting
Rash
Erythema
Increased AST
Frequency not defined
Transient eosinophilia
Post-marketing reports
Rhinorrhea
Alopecia
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: Dimethyl fumarate
Pronounced: [ dye-METH-il-FUE-mar-ate]
Why do we use Dimethyl fumarate?
Dimethyl fumarate is a chemical compound used primarily for multiple sclerosis (MS) treatment. It is typically taken as a capsule or tablet and is used to reduce the frequency and severity of MS relapses. Dimethyl fumarate reduces inflammation in the central nervous system and modifies the immune system’s response to the body’s tissues.
In addition to its use in treating MS, dimethyl fumarate has also been studied for its potential use in treating other immune-mediated disorders, such as psoriasis and Crohn’s disease. It is also being investigated for its potential use in the treatment of certain types of cancer
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