Indoor Tanning and Melanoma Risk: Molecular and Epidemiological Evidence
December 29, 2025
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Brand Name :
Alcoxib, Asogix, Biocoz, Coxet, Coxnuro, Alcox, Arcoxia, Autzib, Coxaday, Coxia, Coxlab, Coxwave
Synonyms :
etoricoxib
Class :
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Brand Name :
Alcoxib, Asogix, Biocoz, Coxet, Coxnuro, Alcox, Arcoxia, Autzib, Coxaday, Coxia, Coxlab, Coxwave
Synonyms :
etoricoxib
Class :
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Dosage Forms & Strengths
Tablet
30 mg
60 mg
90 mg
120 mg
120
mg
Tablet
Oral
once a day
Take a dose of 30 mg orally one time daily and it may be raised to 60 mg one time daily as required
Take a dose of 60 mg orally one time daily and it may be raised to 90 mg one time daily as required
Take a dose of 120 mg orally one time daily
Dosage Forms & Strengths
Tablet
30 mg
60 mg
90 mg
120 mg
For ≥16 years old:
Take a dose of 30 mg orally one time daily and it may be raised to 60 mg one time daily as required
For ≥16 years old:
Take a dose of 60 mg orally one time daily and it may be raised to 90 mg one time daily as required
For ≥16 years old:
Take a dose of 120 mg orally one time daily
Refer to adult dosing
CYP3A strong enhancers of the small intestine may reduce the bioavailability of etoricoxib
it may diminish the metabolism when combined with zuclopenthixol
Combining etoricoxib with pranlukast may cause a reduction in the etoricoxib’s metabolism
When loracarbef is used together with etoricoxib, the risk or seriousness of nephrotoxicity is enhanced
When alprazolam and etoricoxib is used together, this leads to reduction in the alprazolam’s metabolism
When etoricoxib is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When dexrabeprazole and etoricoxib is used together, this leads to reduction in the dexrabeprazole’s metabolism
When etoricoxib is used together with piroxicam, this leads to enhanced risk or seriousness of adverse outcomes
When etoricoxib is used together with somatotropin, this leads to a rise in etoricoxib metabolism
When etoricoxib is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
When cefmenoxime is used together with etoricoxib, this leads to enhanced risk or seriousness of nephrotoxicity
When etoricoxib is used together with proglumetacin, this leads to enhanced risk or seriousness of adverse events
When etoricoxib is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
etoricoxib leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When etoricoxib is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
etoricoxib: it may increase the risk of gastrointestinal bleeding with risedronic acid
etoricoxib: it may decrease the excretion rate of allopurinol
etoricoxib: it may decrease the excretion rate of almasilate
etoricoxib: it may decrease the excretion rate of alogliptin
etoricoxib: it may decrease the excretion rate of bendazac
etoricoxib: it may decrease the excretion rate of caffeine
etoricoxib: it may decrease the excretion rate of canagliflozin
etoricoxib: it may decrease the excretion rate of chlorpheniramine
etoricoxib: it may decrease the excretion rate of chlorthalidone
When etoricoxib is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
When etoricoxib is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
aliskiren: it may increase the risk of renal failure with etoricoxib
Actions and Spectrum
etoricoxib works by inhibiting the enzyme cyclooxygenase-2 (COX-2). COX-2 is responsible for the production of prostaglandins.
etoricoxib reduces the production of prostaglandins associated with pain and inflammation while sparing COX-1.
Frequency not defined
Fluid retention
Increased ALT or AST
Palpitations
Arrhythmia
Abdominal pain
Constipation
Flatulence
Gastritis
Acid reflux
Dyspepsia
Epigastric discomfort
Nausea
Vomiting
Oral ulcer
Asthenia
Fatigue
Headache
Dizziness
Respiratory
Bronchospasm
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
etoricoxib reduces the production of prostaglandins associated with pain and inflammation while sparing COX-1, which is involved in maintaining the protective lining of the stomach.
Pharmacodynamics
etoricoxib’s mechanism of action is the selective inhibition of COX-2, an enzyme responsible for the synthesis of prostaglandins.
Prostaglandins are lipid compounds involved in various physiological processes, including inflammation, pain sensation, and regulation of body temperature.
Pharmacokinetics
Absorption
etoricoxib is absorbed from the gastrointestinal tract after oral administration.
Distribution
etoricoxib distributes into various body tissues.
Metabolism
etoricoxib undergoes hepatic metabolism, primarily through the enzyme CYP3A4 in the liver.
Elimination and excretion
etoricoxib is eliminated from the body through the feces.
Administration
etoricoxib is taken orally in the form of tablet.
Patient information leaflet
Generic Name: etoricoxib
Why do we use etoricoxib?
etoricoxib is also used in the treatment of Rheumatoid Arthritis.
etoricoxib is indicated in treatment of Ankylosing Spondylitis to relieve pain and stiffness.
etoricoxib may be used to manage the pain and inflammation associated with gout.
etoricoxib also used as short-term treatment to relieve acute pain including post-operative pain and dental pain.
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