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Brand Name :
Norvedan
Synonyms :
Fentiazaco, Fentiazacum, fentiazac
Class :
Anti-inflammatory, Nonsteroidal anti-inflammatory drug, Acetic acid derivatives
Dosage Forms & Strengths
Tablet
200 mg
300 mg
Tablets
Oral
Adult oral dosage is 200 to 400 milligrams (mg) daily in two divided doses for symptomatic treatment of upper respiratory tract, genitourinary, and osteoarticular INFLAMMATION and PAIN of various etiologies
A single 100 to 200 mg dose is sufficient for minimal pain. As with other nonsteroidal anti-inflammatory medicines (NSAIDs), an initial 2- to 3-week period on recommended dosage may be required to maximum symptomatic relief, following which dosage should be lowered to the lowest effective level achievable
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
fentiazac may reduce the elimination rate of abacavir, resulting in a greater serum level
when zuclopenthixol is coupled with fentiazac, the risk or severity of hypertension can be raised
when fentiazac is used with warfarin, the risk or severity of bleeding and hemorrhage is enhanced
when coupled with fentiazac, valproic acid's protein binding can be reduced
fentiazac may reduce the elimination rate of amrinone, resulting in a greater serum level
fentiazac may reduce the elimination rate of ampicillin, resulting in a greater serum level
Actions and Spectrum:
Actions:
Fentiazac, like other nonsteroidal anti-inflammatory medicines (NSAIDs), works largely by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2.
Spectrum:
Fentiazac’s mechanism of action is similar to that of other nonsteroidal anti-inflammatory medicines (NSAIDs) in that it primarily works by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis. Fentiazac has the following actions: anti-inflammatory, analgesic (pain reliever), and antipyretic (fever reducer).
Frequency not defined
Edema
Nausea
Peptic ulcers
Vomiting
Heart burn
Indigestion
Anemia
Fluid retention
Elevated liver enzymes
Black tarry stools
Blood vomiting
Drowsiness
Skin rashes
Itching
Swelling
Dizziness
Headaches
Difficulty breathing
Stomach pain
Black Box Warning:
N/A
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Fentiazac is an anti-inflammatory, analgesic, and antipyretic (fever-reducing) nonsteroidal anti-inflammatory medication (NSAID). Its pharmacology is based on its capacity to decrease the activity of cyclooxygenase (COX) enzymes, notably COX-1 and COX-2, which are involved in prostaglandin synthesis.
Pharmacodynamics:
Fentiazac, like many NSAIDs, primarily functions by decreasing the activity of cyclooxygenase (COX) enzymes. COX has two major isoforms: COX-1 and COX-2. COX-1 is constitutively expressed in most tissues and is important in the regular functioning of a variety of physiological functions, including stomach lining maintenance. COX-2 is an inducible variant of the enzyme that has been linked to inflammation and pain. Fentiazac, like other NSAIDs, inhibits both COX-1 and COX-2, which reduces the formation of prostaglandins, which are pain and inflammation mediators.
Pharmacokinetics:
Absorption
Fentiazac is a nonsteroidal anti-inflammatory medication (NSAID) that is normally taken orally. It is absorbed in the gastrointestinal tract after oral dosing. Several factors, including the drug’s formulation and whether it is given with or without meals, can alter the rate and degree of absorption.
Distribution
The bloodstream transports fentiazac throughout the body. It has the potential to attach to plasma proteins, particularly albumin. The drug’s lipophilicity (ability to dissolve in fat) and other physicochemical qualities may influence its distribution.
Metabolism
Fentiazac may be metabolized in the liver, where it can be converted into metabolites via several enzymatic mechanisms. Individual and specific studies may differ in terms of detailed specifics about the actual metabolic pathways and the identity of the metabolites.
Elimination and Excretion
Fentiazac’s elimination half-life varies between persons and may be affected by factors like as age, renal function, and liver function. In most cases, it takes many hours.
Fentiazac and its metabolites are mostly excreted through the urine. Some metabolites may be excreted in the feces as well.
Administration:
Fentiazac is normally used orally, although it may also be available in topical forms such as creams and gels for localized use. A healthcare expert should provide detailed dosage and administration instructions, and it is critical to follow their advice.
Patient information leaflet
Generic Name: fentiazac
Pronounced: fen-TIE-uh-zak
Why do we use fentiazac?
Although it has become less popular in recent years, fentiazac was originally given for its anti-inflammatory and analgesic (pain-relieving) effects. It was used to treat a number of pain and inflammation-related illnesses.
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