floctafenine

Action and Spectrum

Actions and Spectrum:

floctafenine, classified as a nonsteroidal anti-inflammatory drug (NSAID), is primarily employed for its dual properties in pain relief and inflammation control. Its range of effects encompasses the following:

• Pain Alleviation: floctafenine is proficient at relieving diverse types of pain, spanning from mild to moderate discomfort related to issues such as headaches, dental pain, and musculoskeletal aches.
• Inflammation Reduction: Much like other NSAIDs, floctafenine curtails inflammation by inhibiting the activity of enzymes known as cyclooxygenases (COX). These enzymes are involved in the synthesis of inflammatory molecules called prostaglandins. This anti-inflammatory capability renders it valuable in the treatment of conditions characterized by inflammation, such as arthritis.
• Fever Reduction: floctafenine has the ability to lower elevated body temperature, often serving as a remedy for fever accompanying various illnesses.
• Analgesic: It possesses analgesic attributes, implying that it can alleviate pain by influencing the way pain is perceived in the central nervous system.
• Mild Muscle Relaxation: Some studies suggest that floctafenine may exhibit mild muscle relaxant properties, which can be advantageous in certain painful situations.
• Gastrointestinal Considerations: It’s noteworthy that, akin to other NSAIDs, floctafenine may induce gastrointestinal side effects, including stomach irritation and the potential for ulcer formation. Consequently, it is recommended to use it judiciously and consider taking it with food or a stomach-protecting medication.
• Cardiovascular Implications: Floctafenine may have repercussions on cardiovascular health. Therefore, it is of utmost importance for individuals with underlying cardiovascular conditions to seek guidance from a healthcare professional prior to utilizing this medication.

Drug Interaction

Adverse Reaction

Frequency not defined

nausea

stomach cramps

diarrhea

pain

dizziness

heartburn

headache

vomiting

indigestion

Black Box Warning

None

Contraindication / Caution

Contraindication / Caution:

Drowsiness: Some individuals have reported experiencing symptoms like headaches, dizziness, feeling lightheaded, and confusion while using this medication. It is advisable to refrain from operating vehicles or engaging in other potentially risky activities until you are certain that this medication does not affect you in this manner.

Fluid and Electrolyte Balance: The use of this medication has been associated with fluid retention and edema. Individuals with specific medical conditions should be closely monitored by their healthcare provider when taking floctafenine. These conditions include any ailment that may lead to fluid retention, certain heart conditions (e.g., congestive heart failure), high blood pressure, kidney disease, reduced kidney function, or recovery from surgery under general anesthesia.

Risk of Elevated Blood Potassium: There is a potential for increased blood potassium levels with NSAID treatment. Those most vulnerable to this risk include elderly individuals, those with conditions like diabetes or kidney failure, and those taking beta-adrenergic blockers, angiotensin-converting enzyme (ACE) inhibitors, or certain diuretics (water pills).

Cardiovascular Concerns: NSAID medications may heighten the risk of heart attacks, strokes, and blood clots. This risk is more pronounced with higher doses and prolonged use. People with heart-related conditions, such as high blood pressure, high cholesterol, diabetes, peripheral arterial disease, heart failure, or coronary artery disease, should have a discussion with their healthcare provider regarding how this medication may impact their health condition, the influence of their medical condition on dosing and efficacy of this medication, and whether any specialized monitoring is necessary.

Infection: This medication can conceal signs of an infection, like a fever.

Kidney Function: Extended use of floctafenine may increase the likelihood of reduced kidney function. This is most prevalent in individuals who already have kidney disease, liver disease, or heart failure, those taking diuretics (water pills), and the elderly.

Liver Function: This medication may result in liver problems. If you have a pre-existing liver condition, you may require more frequent checkups with your healthcare provider.

Pregnancy / Lactation

Pregnancy warnings:   

Pregnancy category: N/A

Lactation: Excreted into human milk is unknown

Pregnancy Categories:

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Adminstartion

Administration:

Consume floctafenine tablets with a generous glass of water right after a meal or along with food or milk.

Several factors can influence the required medication dose, including body weight, other medical conditions, and concurrent medications. If your doctor has prescribed a dosage distinct from those provided here, refrain from altering your medication regimen without seeking guidance from your healthcare provider.

Patient Information Leaflet

Patient information leaflet

Generic Name: floctafenine

Why do we use floctafenine?

floctafenine is categorized within the group of drugs referred to as nonsteroidal anti-inflammatory drugs (NSAIDs). It is utilized for the temporary management of mild to moderate pain. Its mechanism of action involves inhibiting the substances responsible for inducing pain and inflammation.