fluprednisolone

Action and Spectrum

Actions and Spectrum 

fluprednisolone reduces inflammation by inhibiting the release of inflammatory substances like prostaglandins and leukotrienes. 

It suppresses the immune system, which is beneficial in cases of autoimmune diseases, organ transplant recipients to prevent rejection.

Drug Interaction

Adverse Reaction

Frequency not defined   

None

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• fluprednisolone should avoid in individuals who have a known hypersensitivity or allergy to its components. 

Caution: 

• Patients with a history of gastrointestinal problems should use fluprednisolone with caution. 
• Patients with pre-existing mental health conditions should take caution. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

fluprednisolone works by binding to glucocorticoid receptors in target cells, including immune cells. This binding inhibits the expression of pro-inflammatory genes, reducing the production of inflammatory mediators like prostaglandins. 

fluprednisolone has immunosuppressive effects, making it useful in the treatment of autoimmune diseases and for preventing the rejection of transplanted organs.  

Pharmacodynamics 

fluprednisolone can affect various metabolic processes in the body. It can promote gluconeogenesis and increase blood sugar levels. It can also lead to the breakdown of muscle proteins, contributing to muscle waste. 

Corticosteroids like fluprednisolone can reduce the release of inflammatory mediators in response to allergens, providing relief from allergy symptoms. 

Pharmacokinetics 

Absorption   

fluprednisolone is absorbed from the gastrointestinal tract.  

Distribution 

fluprednisolone is distributed throughout the body through the bloodstream.  

Metabolism 

fluprednisolone undergoes metabolism primarily in the liver.  

Elimination and excretion 

fluprednisolone is excreted through the kidneys. 

Adminstartion

Administration 

fluprednisolone is available in different forms, including oral tablets, topical creams and as injectables solutions. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: fluprednisolone 

Why do we use fluprednisolone? 

fluprednisolone used in treatment of Haemophilia A.  

fluprednisolone can help reduce inflammation and pain in joints for people with rheumatoid arthritis.  

fluprednisolone can be used to relieve symptoms of severe allergic reactions, such as hives or anaphylaxis.