flurandrenolide

Action and Spectrum

Actions and Spectrum: 

• flurandrenolide is a synthetic corticosteroid used as a topical anti-inflammatory and immunosuppressive agent. It works by binding to cytoplasmic glucocorticoid receptors, activating specific genes, and inhibiting others. This results in a decrease in the production of pro-inflammatory cytokines and other mediators of inflammation and a decrease in the recruitment of immune cells to the site of inflammation 
• flurandrenolide have a broad spectrum of activity, meaning it can be used to treat a variety of inflammatory conditions. It is commonly used to treat skin conditions such as eczema, psoriasis, dermatitis, and other inflammatory conditions such as asthma, allergic rhinitis, and inflammatory bowel disease 

Drug Interaction

Adverse Reaction

Frequency not defined 

Skin atrophy 

Striae 

Acneform lesions 

Hypertrichosis 

Acne 

Pigmentation changes 

HPA suppression 

Skin atrophy 

Secondary infection 

Eruptions 

Miliaria 

Burning 

Black Box Warning

Contraindication / Caution

Contraindications/caution: 

Contraindications: 

• Hypersensitivity to flurandrenolide: Individuals with a known allergy or hypersensitivity to flurandrenolide or its components should not use this medication 
• Viral infections: flurandrenolide may worsen viral infections such as herpes or chickenpox. It is not recommended for use in individuals with active viral infections 
• Fungal infections: flurandrenolide may worsen fungal infections. It is not recommended for use in individuals with active fungal infections 
• Bacterial infections: flurandrenolide may mask the symptoms of bacterial infections or worsen existing bacterial infections. It is not recommended for use in individuals with active bacterial infections 
• Vaccinations: flurandrenolide may reduce the effectiveness of certain vaccines. Waiting at least two weeks after using this medication before receiving a vaccination is recommended. 
• Pregnancy and breast-feeding: flurandrenolide may be harmful to the fetus or infant. It is not recommended during pregnancy or while breast-feeding unless the potential benefits outweigh the risks 
• Pediatric use: flurandrenolide is not recommended for use in children under two years of age unless directed by a healthcare professional. 

Caution: 

• Diabetes: flurandrenolide may increase blood sugar levels and require close monitoring in individuals with diabetes 
• Hypertension: flurandrenolide may increase blood pressure and require close monitoring in individuals with hypertension 
• Ocular herpes simplex: flurandrenolide should be used with caution in individuals with a history of ocular herpes simplex, as it may exacerbate the condition 
• Immunosuppression: flurandrenolide is an immunosuppressive medication that may increase the infection risk. It should be used cautiously in individuals who are immunosuppressed or have a history of recurrent infections 
• Use on the face: flurandrenolide should be used with caution on the face, as it may cause skin thinning, acne, or other adverse effects 
• Long-term use: Prolonged use of flurandrenolide may cause skin thinning, stretch marks, or other adverse effects 
• Withdrawal: Abrupt discontinuation of flurandrenolide may cause rebound inflammation or other adverse effects. 

Pregnancy / Lactation

Pregnancy consideration: C 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

• flurandrenolide is a synthetic corticosteroid with potent anti-inflammatory, anti-pruritic, and vasoconstrictive properties. It is available in a topical cream or ointment formulation for dermatological use 
• flurandrenolide binds to cytoplasmic glucocorticoid receptors, which then translocate to the nucleus and interact with specific DNA sequences, transcribing anti-inflammatory proteins. This reduces the production of inflammatory cytokines, chemokines, and other mediators of inflammation, reducing inflammation and symptoms such as itching and redness. 

Pharmacodynamics: 

• The pharmacodynamics of flurandrenolide is primarily attributed to its corticosteroid properties, specifically its ability to bind to glucocorticoid receptors and induce anti-inflammatory effects 
• flurandrenolide induces conformational changes that enable the complex to translocate to the nucleus upon binding to cytoplasmic glucocorticoid receptors.  
• Here, the complex interacts with specific DNA sequences, leading to the transcription of anti-inflammatory proteins, such as lipocortin’s. Lipocortins, in turn, inhibits the activity of phospholipase A2, resulting in reduced production of arachidonic acid and other pro-inflammatory mediators, including prostaglandins and leukotrienes. 

Pharmacokinetics: 

Absorption 

flurandrenolide is primarily absorbed topically through the skin, and its absorption may be influenced by various factors such as the formulation used, the site of application, and the integrity of the skin. 

Distribution 

flurandrenolide is distributed throughout the body after absorption, but it primarily remains localized in the skin tissues where it is applied. 

Metabolism 

flurandrenolide is metabolized in the liver by various enzymatic processes, including oxidation and conjugation reactions, and it undergoes extensive first-pass metabolism. The primary metabolites of flurandrenolide are inactive and are excreted in the urine. 

Elimination and Excretion 

The metabolites of flurandrenolide are eliminated primarily in the urine, with a small amount excreted in the feces 

Adminstartion

Administration: 

flurandrenolide is a topical medication and is administered externally to the affected areas of the skin. It is available in various forms, such as creams, ointments, and tapes 

Patient Information Leaflet

Patient information leaflet 

Generic Name: flurandrenolide 

Pronounced: [ FLUR-an-DREN-oh-lide ] 

Why do we use flurandrenolide? 

flurandrenolide is a topical corticosteroid medication that is primarily used in the treatment of various skin conditions, including: 

• Eczema: flurandrenolide is often prescribed to treat eczema, characterized by red, itchy, and inflamed skin. It works by reducing inflammation and itching, which can help alleviate eczema symptoms. 

• Psoriasis: flurandrenolide may also be used to treat psoriasis, a chronic skin condition characterized by the buildup of skin cells that result in thick, scaly patches on the skin. The medication can help to reduce inflammation and scaling of the affected areas. 

• Contact dermatitis: flurandrenolide can treat contact dermatitis, an inflammatory skin condition caused by exposure to an irritant or allergen. The medication can help to reduce inflammation and itching associated with the condition. 

• Atopic dermatitis: flurandrenolide may also be used in the treatment of atopic dermatitis, which is a chronic inflammatory skin condition characterized by dry, itchy, and inflamed skin. 

• Other skin conditions: flurandrenolide may also be prescribed to treat other skin conditions, such as lichen planus, discoid lupus erythematosus, and other inflammatory skin disorders.