Detection of Suspected Paper Mill Publications in Cancer Research Using Machine Learning
January 30, 2026
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Brand Name :
N/A
Synonyms :
gimeracil
Class :
Cytotoxic Chemotherapy
Brand Name :
N/A
Synonyms :
gimeracil
Class :
Cytotoxic Chemotherapy
Dosage Forms & Strengths
Capsule
20 mg
In combination with tegafur and oteracil:
Take a dose of 40 mg/m2 as per body surface area two times daily for one week pre-operatively and for 15 days after operation starting on day 15 after operation
Not determined
Refer to adult dosing
may enhance the plasma concentration of fluorouracil-derived products
Actions and Spectrum
gimeracil is a dihydropyrimidine dehydrogenase (DPD) inhibitor, which prevents the enzyme from degrading and inactivating the chemotherapeutic medication 5-fluorouracil (5-FU).
gimeracil works better to destroy cancer cells that divide quickly by increasing the content of active 5-FU inside cancer cells by inhibiting DPD.
Frequency not defined
Sore mouth
Fatigue
Loss of appetite
Constipation
Brittle nails
Drowsiness
Change in taste
Diarrhea
Rash
Headaches
Photosensitivity
Confusion
Insomnia
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The pharmacological action of gimeracil is to block the activity of the enzyme dihydropyrimidine dehydrogenase (DPD).
It oversees the body’s ability to break down the chemotherapeutic medication 5-fluorouracil (5-FU).
Pharmacodynamics
Increased levels of active 5-FU are seen in cancer cells because of gimeracil’s suppression of DPD.
A cytotoxic antimetabolite called 5-FU disrupts DNA synthesis and function, which ultimately causes cell death.
Pharmacokinetics
Absorption
gimeracil is absorbed from the gastrointestinal tract and enters the bloodstream.
Distribution
gimeracil is distributed throughout the body.
Metabolism
gimeracil undergoes metabolic processes in the liver.
Elimination and excretion
gimeracil is primarily excreted through the renal route.
Administration
gimeracil is administered orally and it is available in tablet and capsule form.
Patient information leaflet
Generic Name: gimeracil
Why do we use gimeracil?
gimeracil is used as part of combination therapy for the treatment of Resectable gastric carcinoma. gimeracil is used in combination with tegafur and oteracil as a chemotherapy for various gastrointestinal cancers including Colorectal cancer and Pancreatic cancer.
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