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Brand Name :
N/A
Synonyms :
tegafur
Class :
Antineoplastic agents
Brand Name :
N/A
Synonyms :
tegafur
Class :
Antineoplastic agents
Dosage forms and strengths Â
Oral capsuleÂ
100 mgÂ
Indicated for Advanced colorectal cancer
Three daily divided doses of 300 mg/m2 tegafur in combination with 672 mg/m2 uracil orally with calcium folinate
These doses are administered over a 28-day cycle, followed by a seven-day treatment-free interval
Indicated for Malignant neoplasm
The maximum dose is 1 g/m² orally every day, generally combined with uracil
Indicated for Malignant neoplasms
Administer 1 to 3 g/m² intravenously every day for five days
Not indicatedÂ
Refer adult dosingÂ
methoxypolyethylene glycol-epoetin betaÂ
combining tegafur with methoxy polyethylene glycol-epoetin beta can raise the risk or severity of thrombosis
Combining tegafur with abiraterone can reduce tegafur’s metabolism
Combining tegafur with acalabrutinib can reduce tegafur’s metabolism
Combining tegafur with acenocoumarol can reduce tegafur’s metabolism
Combining tegafur with acetaminophen can reduce tegafur’s metabolism
Combining tegafur with acyclovir can reduce tegafur’s metabolism
Combining tegafur with alfentanil can reduce tegafur’s metabolism
Combining tegafur with almotriptan can reduce tegafur’s metabolism
Combining tegafur with alosetron can reduce tegafur’s metabolism
Combining tegafur with alpelisib can reduce tegafur’s metabolism
Combining tegafur with alprazolam can reduce tegafur’s metabolism
Combining tegafur with ambrisentan can reduce tegafur’s metabolism
Combining tegafur with aminophenazone can reduce tegafur’s metabolism
Combining tegafur with aminophylline can reduce tegafur’s metabolism
Combining tegafur with amiodarone can reduce tegafur’s metabolism
Combining tegafur with amodiaquine can reduce tegafur’s metabolism
Combining tegafur with amphetamine can reduce tegafur’s metabolism
Combining tegafur with amprenavir can reduce tegafur’s metabolism
Combining tegafur with anagrelide can reduce tegafur’s metabolism
Combining tegafur with anakinra can reduce tegafur’s metabolism
Combining tegafur with anastrozole can reduce tegafur’s metabolism
Combining tegafur with antipyrine can reduce tegafur’s metabolism
Combining tegafur with apixaban can reduce tegafur’s metabolism
Combining tegafur with aprepitant can reduce tegafur’s metabolism
Combining tegafur with arformoterol can reduce tegafur’s metabolism
Combining tegafur with aripiprazole can reduce tegafur’s metabolism
Combining tegafur with atazanavir can reduce tegafur’s metabolism
Combining tegafur with atorvastatin can reduce tegafur’s metabolism
Combining tegafur with axitinib can reduce tegafur’s metabolism
Combining tegafur with azathioprine can reduce tegafur’s metabolism
Combining tegafur with betaxolol can reduce tegafur’s metabolism
Combining tegafur with bexarotene can reduce tegafur’s metabolism
Combining tegafur with bortezomib can reduce tegafur’s metabolism
Combining tegafur with bosutinib can reduce tegafur’s metabolism
Combining tegafur with bromazepam can reduce tegafur’s metabolism
Combining tegafur with buprenorphine can reduce tegafur’s metabolism
Combining tegafur with buspirone can reduce tegafur’s metabolism
Combining tegafur with cabozantinib can reduce tegafur’s metabolism
Combining tegafur with caffeine can reduce tegafur’s metabolism
Combining tegafur with cannabidiol can reduce tegafur’s metabolism
Combining tegafur with carbamazepine can reduce tegafur’s metabolism
Combining tegafur with carmustine can reduce tegafur’s metabolism
Combining tegafur with chloroquine can reduce tegafur’s metabolism
Combining tegafur with chlorpheniramine can reduce tegafur’s metabolism
Combining tegafur with chlorpromazine can reduce tegafur’s metabolism
Combining tegafur with cinnarizine can reduce tegafur’s metabolism
Combining tegafur with ciprofloxacin can reduce tegafur’s metabolism
Combining tegafur with cisapride can reduce tegafur’s metabolism
Combining tegafur with citalopram can reduce tegafur’s metabolism
Combining tegafur with clindamycin can reduce tegafur’s metabolism
Combining tegafur with clofibrate can reduce tegafur’s metabolism
Combining tegafur with clomipramine can reduce tegafur’s metabolism
Combining tegafur with clopidogrel can reduce tegafur’s metabolism
Combining tegafur with clozapine can reduce tegafur’s metabolism
Combining tegafur with crizotinib can reduce tegafur’s metabolism
Combining tegafur with curcumin can reduce tegafur’s metabolism
Combining tegafur with cyclophosphamide can reduce tegafur’s metabolism
Combining tegafur with cyclosporine can reduce tegafur’s metabolism
Combining tegafur with dacarbazine can reduce tegafur’s metabolism
Combining tegafur with dapsone can reduce tegafur’s metabolism
Combining tegafur with dasabuvir can reduce tegafur’s metabolism
Combining tegafur with dasatinib can reduce tegafur’s metabolism
Combining tegafur with dextromethorphan can reduce tegafur’s metabolism
Combining tegafur with diacerein can reduce tegafur’s metabolism
Combining tegafur with diazepam can reduce tegafur’s metabolism
Combining tegafur with diclofenac can reduce tegafur’s metabolism
Actions and Spectrum:Â
Action:Â
Inhibition of Thymidylate Synthase:Â Â
5-FU inhibits the enzyme thymidylate synthase; by blocking this enzyme, 5-FU reduces the production of thymidine, leading to DNA damage and interfering with the replication of DNA.Â
Spectrum:Â Â
Colorectal Cancer: 5-FU is a critical component in many chemotherapy regimens for colorectal Cancer.Â
Breast Cancer: It may be used in breast cancer treatment, often in combination with other drugs.Â
Frequency not defined Â
myocardial ischaemiaÂ
ocular irritationÂ
alopeciaÂ
stomatitisÂ
oedemaÂ
mucositisÂ
anorexiaÂ
vomitingÂ
NauseaÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: tegafur should not be used in individuals with known hypersensitivity or allergy to the drug or its componentsÂ
Pregnancy and Breastfeeding: tegafur is contraindicated during pregnancy, as it can harm the developing foetus. Breastfeeding mothers should also refrain from consuming it, as it can be transmitted through breast milk and potentially endanger the health of the nursing baby.Â
Severe Bone Marrow Suppression: Individuals with severe bone marrow suppression, which can lead to dangerously low blood cell counts (e.g., leukopenia, thrombocytopenia, or anemia), should not use tegafur. This medication can exacerbate these conditions.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: tegafur is a medication primarily used as a prodrug in cancer therapy, specifically for treating certain types of Cancer.Â
Pharmacodynamics:Â Â
Conversion to 5-Fluorouracil: tegafur is metabolized in the body to 5-FU, the active component responsible for its anticancer effects. This conversion primarily occurs in the liver through the action of various enzymes, including cytochrome P450 enzymes.Â
Inhibition of DNA and RNA Synthesis: 5-FU interferes with DNA and RNA synthesis within rapidly dividing cancer cells. It becomes integrated into the developing nucleic acid strands, causing their configuration and operation disturbances. Consequently, this results in the suppression of cellular replication and eventual demise of the cell.  Â
Pharmacokinetics:Â
AbsorptionÂ
tegafur is well-absorbed from the gastrointestinal tract after oral administration.Â
DistributionÂ
Both tegafur and its active metabolite, 5-FU, are distributed widely throughout the body.Â
MetabolismÂ
tegafur is primarily metabolized in the liver to 5-FU. The conversion of tegafur to 5-FU is influenced by individual variations in enzyme activity, which can impact drug efficacy and toxicity.Â
Excretion and EliminationÂ
Both tegafur and 5-FU are eliminated from the body through various pathways, including renal excretion.Â
Administration: Â
The route of administration is by IV route & oral route.Â
Patient information leafletÂ
Generic Name: tegafurÂ
Why do we use tegafur? Â
Colorectal Cancer: tegafur is often used with other chemotherapy drugs to treat colorectal (colon and rectal) cancer.Â
Breast Cancer: tegafur in combination with other medications may be used to treat breast cancer, particularly in cases where the cancer has spread or is recurrent.Â
Stomach (Gastric) Cancer: tegafur can be employed as part of a chemotherapy regimen for stomach cancer. It helps to shrink tumors and slow the progression of the disease.Â
Pancreatic Cancer: In some cases, tegafur treats pancreatic cancer as part of a combination chemotherapy approach.Â
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