DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse drug reactions:    

Frequency defined  

>10%  

Headache  

Peripheral edema  

1-10%  

Constipation  

Dyspnea  

Nasal congestion  

Palpitations  

Flushing  

Abdominal pain  

Nasopharyngitis  

Sinusitis  

Postmarketing Reports  

Anemia  

Dizziness  

Fatigue  

Fluid retention  

  

  

Pregnancy warnings:    
Pregnancy category: N/A 

Lactation: Drug enters breast milk is unknown 

Pregnancy Categories:       

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first trimester or the later trimester       
• Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women       
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits       
• Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women       
• Category N: There is no data available for the drug under this category      

Patient Information Leaflet    

Generic Name: ambrisentan (Rx) 

Why do we use ambrisentan (Rx)? 

ambrisentan (Rx) belongs to the class Endothelin Antagonists and helps to treat Pulmonary Arterial Hypertension.