vardenafil

medtigo

vardenafil

Brand Name :

Staxyn ODT, Levitra

Synonyms :

vardenafil, vardenafilo, vardenafilum

Class :

Phosphodiesterase-5 Enzyme Inhibitors

Action and Spectrum

Actions and Spectrum:

vardenafil is a medication used to treat erectile dysfunction (ED) in men. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which work by increasing blood flow to the penis, leading to improved erectile function.

The actions of vardenafil include:

Increasing blood flow to the penis: vardenafil relaxes the smooth muscle cells in the blood vessels that supply the penis, allowing for increased blood flow.
Improved erectile function: By increasing blood flow to the penis, vardenafil can help men with ED achieve and maintain an erection.
Shorter onset time: vardenafil has a shorter onset time than other PDE5 inhibitors, meaning it can take effect more quickly after administration.

The spectrum of vardenafil includes:

Treatment of erectile dysfunction: vardenafil is primarily used to treat ED in men.
Pulmonary arterial hypertension: vardenafil has also been used off-label to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries that supply the lungs.
Raynaud’s phenomenon: vardenafil has also been used off-label to treat Raynaud’s phenomenon, a condition in which the blood vessels in the fingers and toes constrict in response to cold or stress.

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency defined

>10%

Headache

Flushing

1-10%

Rhinitis

Dyspepsia

Flulike syndrome

Sinusitis

Back pain

Dizziness

Nausea

<1%

Anaphylaxis

Angina

Insomnia

Myocardial infarction

Postural hypotension

Priapism

Pruritus

Rash

Black Box Warning

Contraindication / Caution

The drug is contraindicated in patients hypersensitive to vardenafil.

Pregnancy / Lactation

Pregnancy consideration:

Category B

Breastfeeding warnings:

Excretion of vardenafil in breastmilk is unknown

Pregnancy category:

Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a product in humans; Pregnant women must take care of the potential risks.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh risks over benefits. The drug is not for pregnant women.
Category N: No data is available for the drug under this category.

Pharmacology

Pharmacology:

vardenafil is a medication that belongs to the class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. It works by blocking the action of the enzyme PDE5, which usually breaks down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells lining the blood vessels of the penis.

cGMP is a molecule that acts as a messenger, signaling the smooth muscle cells to relax, which allows blood to flow into the penis, leading to an erection. By blocking PDE5, vardenafil increases cGMP levels, improving blood flow to the penis and improving erectile function.

Pharmacodynamics:

The pharmacodynamics of vardenafil involves its ability to inhibit PDE5, which results in increased levels of cGMP and improved erectile function. vardenafil has more excellent selectivity for PDE5 than other PDE isoforms, reducing the likelihood of side effects.

Pharmacokinetics:

Absorption

The drug is rapidly absorbed

Bioavailability is 15%

The onset of action is 60 minutes

The peak plasma time is 30-120 min

Distribution

The protein-bound is 95%

The volume of distribution is 208L

Metabolism

The drug is metabolized in the liver by CYP2C9 and CYP3A4

The metabolites formed are M1

Elimination and Excretion

The half-life is 3-6 hours

The rate of total body clearance is 56 L/hr

The drug is excreted 95% in feces and 5% in urine

Adminstartion

Administration:

vardenafil is a medication typically taken orally, about 30 to 60 minutes before sexual activity. The medication is in tablet form and should be taken with a full glass of water.

The recommended starting dose of vardenafil is 10 mg, although the dose may be adjusted based on individual response and tolerability. The maximum recommended dose is 20 mg per day.

vardenafil should not be taken more than once per day, and it should not be taken with grapefruit juice or high-fat meals, as these can affect the absorption and effectiveness of the medication.

Individuals taking vardenafil should avoid alcohol and not take the medication with other drugs that can interact with it, such as nitrates or nitric oxide donors.

Patient Information Leaflet

Patient information leaflet

Generic Name: vardenafil

Pronounced: var-DEN-a-fil

Why do we use vardenafil?

vardenafil is used to treat erectile dysfunction (ED) in adult men. Erectile dysfunction is when a man has difficulty achieving or maintaining an erection sufficient for sexual activity. vardenafil works by increasing blood flow to the penis, which helps to improve erectile function. vardenafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which also include sildenafil (Viagra) and tadalafil (Cialis).

These medications all work by inhibiting the action of the enzyme PDE5, which breaks down cyclic guanosine monophosphate (cGMP), a molecule that plays a role in erectile function. By blocking PDE5, vardenafil increases cGMP levels in the smooth muscle cells of the penis, leading to improved blood flow and better erectile function.

vardenafil

No data available for drug.

DRUG INTERACTION

vardenafil

&

vardenafil +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

vardenafil

No data available for drug.

DRUG INTERACTION

vardenafil

&

vardenafil +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

vardenafil

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

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