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Brand Name :
Angispan, Vasovin XI, Nitract, Angiplat, Nitroject, Angistat, Nitrogard, Nitroglyn
Synonyms :
glyceryl trinitrate, nitroglycerin
Class :
Anti-anginal agents
Brand Name :
Angispan, Vasovin XI, Nitract, Angiplat, Nitroject, Angistat, Nitrogard, Nitroglyn
Synonyms :
glyceryl trinitrate, nitroglycerin
Class :
Anti-anginal agents
Dosage forms and strength
Tablet
500 mg
600 mg
Keep 1 tablet under the tongue and allow it to dissolve slowly
Repeat after 5 minutes if symptoms are not relieved
Pediatric
Not determined
Drug-Subclass interaction:
Antihypertensive agents: an increase in hypotensive effects may be seen
Vasodilators: an increase in hypotensive effects may be seen
Neuroleptics: an increase in hypotensive effects may be seen
TCAs: an increase in hypotensive effects may be seen
MAOIs: an increase in hypotensive effects may be seen
Anticholinergics: the absorption of glyceryl trinitrate may be reduced
Heparin: the anticoagulant effect of heparin can be decreased
Fatal:
Phosphodiesterase type 5 inhibitors: potential hypotensive effects may be seen
Riociguat: potential hypotensive effects may be seen
Actions and spectrum:
Glyceryl trinitrate produces free nitric oxide radicals. They activate guanylate cyclase and raise guanosine monophosphate (cGMP) in smooth muscle.
They dilate coronary arteries and enhance collateral flow to ischemic areas, also lowering cardiac oxygen demand.
Frequency not defined
Methemoglobinemia
Hypoxaemia
Vertigo
Paradoxical bradycardia
Severe hypotension
Tachycardia
Asthenia
Cerebral ischemia
Restlessness
Syncope
Orthostatic hypotension
Increase in intracranial pressure
Black box warning
None
Contraindication/Caution:
Contraindication:
Increased cranial pressure
Extreme bradycardia
Severe hypotension
Migraine
Cautions:
Lung disease
Cerebrovascular disease
Hypothyroidism
Orthostatic dysfunction
Hepatic impairment
Renal impairment
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
Glyceryl trinitrate is known as nitroglycerin. It is an anti-anginal agent used mainly in the treatment of angina pectoris.
Pharmacodynamics:
Glyceryl trinitrate causes vasodilation and decreases preload. It enters vascular smooth muscle and gets converted to nitric oxide thus it leads to the activation of cGMP and vasodilation.
Pharmacokinetics:
Absorption
It is rapidly absorbed from the sublingual mucosa.
Distribution
It is widely distributed in the body.
Metabolism
It undergoes hepatic metabolism.
Elimination and excretion
It is eliminated through urinary route.
Administration:
It is taken orally as oral dosage form.
Patient information leaflet
Generic Name: glyceryl trinitrate
Why do we use glyceryl trinitrate?
Glyceryl trinitrate is indicated in the treatment of angina pectoris.
It is also used to treat myocardial infarction, congestive heart failure and unstable angina.
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