hyaluronic acid, non-animal stabilized

Action and Spectrum

Actions and Spectrum: 

Action: 

Hydration: Drug has an exceptional ability to retain water molecules. When injected into the skin or applied topically, it attracts and binds moisture, helping to hydrate the skin and improve its elasticity and plumpness. This action contributes to a more youthful and refreshed appearance. 

Wrinkle reduction: Drug can fill in and reduce the appearance of wrinkles and fine lines. When injected into the skin, it adds volume and lifts sagging areas, providing a smoother, more youthful look. This action is often used in cosmetic procedures such as dermal fillers. 

Spectrum: 

Cosmetic applications: Drug is widely used  aesthetics for various cosmetic procedures. It can be used as a dermal filler to enhance facial contours, plump lips, and reduce the appearance of wrinkles. Additionally, drug-based products are used in skincare formulations to improve hydration and overall skin quality. 

Medical applications: Drug has medical applications beyond cosmetics. It is used in orthopedics to provide joint lubrication, particularly in cases of osteoarthritis.

Drug Interaction

Adverse Reaction

Frequency defined  

>10% 

Juvederm (all formulations) 

Itching (11.4-33%) 

Pain after injection (33.3-47%) 

Discoloration (18.9-78%) 

Lumps/ bumps (38.6-75%) 

Redness (34.8-81%) 

Tenderness to touch (47.7-81%) 

Firmness (33.3-89%)  

Restylane (all formulations) 

Lip swelling (43%) 

Contusion (44%) 

Itching (47.2%) 

Pain (8-76.1%) 

Bruising (78.2%) 

Redness (80.3%) 

Tenderness (86.6%) 

Swelling (89.4%) 

Belotero Balance (all formulations) 

Pruritus (21.8%) 

Discoloration (28.9%) 

Nodule (43.6%) 

Pain (48.8%) 

Induration (50.7%) 

Erythema (51.7%) 

Bruising (54.5%) 

Swelling (68.7%) 

1-10% 

Restylane (all formulations) 

Other (2.1%) 

Headache (5%) 

Lip disorder (5%) 

Lip pain (10%) 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Allergy or hypersensitivity: Individuals with a known allergy or hypersensitivity to hyaluronic acid or any of the components in the drug filler should avoid treatment.  

Active skin infection or inflammation: If you have an active skin infection or inflammation at the treatment site, waiting until the condition resolves is generally recommended before undergoing drug filler injections. This is to prevent complications and ensure optimal results. 

Bleeding disorders or use of blood-thinning medications: If you have a bleeding disorder or are taking medications that thin the blood (e.g., aspirin, warfarin), it may increase the risk of bleeding or bruising at the injection site.  

Pregnancy and breast-feeding: The safety of drug fillers during pregnancy and breastfeeding has not been extensively studied, so it’s typically advised to avoid treatment during these periods as a precautionary measure. 

Autoimmune diseases and immune system disorders: Individuals with autoimmune diseases or other immune system disorders may have an increased risk of adverse reactions or complications from drug fillers. It’s important to discuss your medical history with your healthcare provider. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category  

Pharmacology

Pharmacology: Non-animal stabilized hyaluronic acid (NASHA) is a specific type of hyaluronic acid that is chemically modified and formulated to enhance its stability and durability. 

Pharmacodynamics:  

Dermal Filling: The injected drug fills the space under the skin, providing immediate results and promoting a more youthful appearance. The effects of drug fillers are temporary and gradually diminish over time. 

Cross-Linking: Drug is chemically modified through cross-linking, increasing the drug molecules’ stability and longevity. The cross-linking agents used in drug products vary among manufacturers and can influence the properties and duration of the effects. 

Pharmacokinetics: 

Absorption 

When applied topically, drug can penetrate the stratum corneum (outermost layer of the skin) and reach the underlying dermis. However, the extent of absorption depends on various factors such as the drug’s molecular weight, formulation characteristics, and the condition of the skin barrier. Higher molecular weight drug tends to have limited absorption compared to lower molecular weight forms. 

Distribution 

Drug can distribute within the skin tissue and provide hydration and support. It does not typically show significant systemic distribution as it primarily acts locally at the site of application. 

Metabolism 

Drug is not metabolized in the body. It is enzymatically degraded by hyaluronidases, which are naturally present in the skin and other tissues. This enzymatic degradation regulates the turnover of drug in the body. 

Excretion and Elimination 

Drug breakdown products are eventually eliminated from the body. Drug degradation products are small molecules that can be cleared through lymphatic drainage or further metabolized into other compounds. 

Adminstartion

Administration:  

Once the treatment area is prepared, the healthcare professional will inject Drug into the targeted areas using a fine-gauge needle or cannula. The specific injection technique and depth will depend on the desired outcome and the area being treated.

The healthcare professional will carefully control the amount and distribution of the drug to achieve optimal results. The procedure usually takes a relatively short amount of time, and multiple injections may be necessary to achieve the desired outcome. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: hyaluronic acid, non-animal stabilized 

Why do we use hyaluronic acid, non-animal stabilized?  

Dermal Fillers: Drug is commonly used in cosmetic procedures as a dermal filler. It reduce the appearance of wrinkles, and enhance facial contours.  

Lip Augmentation: Drug can be used to enhance the shape and size of the lips. It is injected into the lips to provide a fuller and more defined appearance.  

Scar Revision: Drug injections can minimize the appearance of scars, including acne and surgical scars. By injecting it into the affected area, it helps to plump up the skin, making the scar less noticeable and promoting a smoother texture. 

Joint Lubrication: In the field of medicine,Drug is used for the treatment of osteoarthritis.It acts as a cushioning agent, helping to restore joint mobility and alleviate discomfort. 

Eye Surgery: The drug is used in ophthalmic surgery to protect and lubricate the eye during cataract surgery and corneal transplantation. Its viscoelastic properties make it an ideal substance for maintaining the structure and function of the eye during surgical interventions.