Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
Buscopan, Buscopan IBS relief,
Synonyms :
Scopolamine butyl bromide, hyoscine butyl bromide
Class :
Antispasmodics
Brand Name :
Buscopan, Buscopan IBS relief,
Synonyms :
Scopolamine butyl bromide, hyoscine butyl bromide
Class :
Antispasmodics
Dosage Forms & Strengths
Parenteral solutions
20mg/1ml
Tablets
10mg
20mg
Transdermal patch
1.5mg
Irritable Bowel Syndrome (IBS)
Initial dose: 10mg orally thrice daily:
10
mg
oral
3 times a day
Note: The dose may be increased up to 20mg four times a day
pre-operative medication 0.2mg- 0.6mg intramuscular, intravenous, or subcutaneous half-an-hour to one hour before anesthesia
Preoperative medication
0.2mg- 0.6mg intramuscular, intravenous, or subcutaneous half-an-hour to one hour before anesthesia
Apply one patch transdermal behind the ear prior to surgery in the evening or an hour before the C-section
Dosage Forms & Strengths
Parenteral solutions
20mg/1ml
Tablets
10mg
20mg
Transdermal patch
1.5mg
Irritable Bowel Syndrome (IBS)
For children of age 6 to 11 years of age:
10mg thrice daily
For children of age 12 years and above:
Initial dose: 10mg orally thrice daily
Note: The dose may be increased up to 20mg four times a day
0.006 mg/kg intramuscular or subcutaneous as a single dose
0.006 mg/kg intramuscular or subcutaneous as a single dose
Not recommended for use in children below ten years of age
For children of age more than ten years of age:
Apply one patch transdermal behind the ear prior to surgery in the evening or an hour before the C-section
Refer to adult dosing
the sedative property of hyoscine may be increased
the sedative property of hyoscine may be increased
the sedative property of hyoscine may be increased
the sedative property of hyoscine may be increased
the sedative property of hyoscine may be increased
dexchlorpheniramine, dextromethorphan, and phenylephrine
the activity of hyoscine may be increased
the activity of hyoscine may be increased
the activity of hyoscine may be increased
the activity of hyoscine may be increased
the activity of hyoscine may be increased
the activity of hyoscine may be increased
Actions and spectrum:
Hyoscine is an antimuscarinic tertiary amine. It exhibits spasmolytic effects on smooth muscles and inhibits secretions by blocking the action of acetylcholine in secretory glands, the CNS, and the smooth muscles of the gastrointestinal, biliary, and urinary tracts. Additionally, it prevents motion-induced nausea and vomiting by blocking the transmission of cholinergic impulses from the vestibular nuclei to the central nervous system.
Frequency not defined
Bradycardia
Ulcers in oesophagus
Contact dermatitis
Rambling speech
Hallucinations
Blurred vision
Agitation
Erythema
Ataxia
Amnesia
Idiosyncratic reactions
Dizziness
Behavioral abnormalities
Black Box Warning
Do not operate machinery or drive vehicles
Contraindication/Caution:
Contraindication:
Hypersensitivity
Narrow-angle glaucoma
Megacolon
Myasthenia gravis
Tachycardia
Precautions
Pyrexia
Paralytic ileus
Prostatic hypertrophy
Psychosis
Hepatic failure
Renal failure
Coronary artery disease
Cardiac failure
Pregnancy
Lactation
Pregnancy consideration:
USFDA pregnancy category: C
Lactation:
To be used with caution in lactating mothers as the drug is known to be excreted in breast milk. The benefits should outweigh the risks.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Hyoscine butylbromide is an anticholinergic and antispasmodic agent. It is used in relieving cramps associated with the GI tract and cramps in the bladder due to kidney stones
Pharmacodynamics:
Hyoscine butylbromide exerts action by stopping the muscular contractions by relaxing stomach muscles and relieving pain, cramps, bloating etc.
Pharmacokinetics:
Absorption
Hyoscine butylbromide is readily absorbed from the GI tract.
Distribution
The drug crosses the blood-brain barrier. The volume of distribution is 128L, and approximately 4% of the drug is bound to proteins.
Metabolism
Hyoscine butylbromide undergoes hepatic metabolism through conjuagtion
Elimination and excretion
Less than 10% of the unchanged drug is eliminated in urine. 42-61% of the drug as butybromide in unchanged form is eliminated through urine and 28-37% as feces.
Half life:
Administration:
To be administered as directed by the physician
Patient information leaflet
Generic Name: hyoscine butylbromide
Why do we use hyoscine butylbromide?
Hyoscine butylbromide is an anticholinergic agent. It is used to relieve spasms of the genitourinary and gastrointestinal tract, motion sickness, irritable bowel syndrome, nausea, vomiting, vertigo, etc.
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