hyoscine butylbromide

Action and Spectrum

Actions and spectrum: 

Hyoscine is an antimuscarinic tertiary amine. It exhibits spasmolytic effects on smooth muscles and inhibits secretions by blocking the action of acetylcholine in secretory glands, the CNS, and the smooth muscles of the gastrointestinal, biliary, and urinary tracts. Additionally, it prevents motion-induced nausea and vomiting by blocking the transmission of cholinergic impulses from the vestibular nuclei to the central nervous system. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Bradycardia 

Ulcers in oesophagus 

Contact dermatitis 

Rambling speech 

Hallucinations 

Blurred vision 

Agitation 

Erythema 

Ataxia 

Amnesia 

Migraine 

Idiosyncratic reactions 

Dizziness 

Behavioral abnormalities

Black Box Warning

Black Box Warning  

Do not operate machinery or drive vehicles 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity  

Narrow-angle glaucoma 

Megacolon 

Myasthenia gravis 

Tachycardia  

Precautions 

Pyrexia 

Paralytic ileus 

Prostatic hypertrophy 

Psychosis 

Hepatic failure 

Renal failure 

Coronary artery disease 

Cardiac failure 

Pregnancy  

Lactation  

Pregnancy / Lactation

Pregnancy consideration:  

USFDA pregnancy category: C 

Lactation:  

To be used with caution in lactating mothers as the drug is known to be excreted in breast milk. The benefits should outweigh the risks. 

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: 

Hyoscine butylbromide is an anticholinergic and antispasmodic agent. It is used in relieving cramps associated with the GI tract and cramps in the bladder due to kidney stones 

Pharmacodynamics: 

Hyoscine butylbromide exerts action by stopping the muscular contractions by relaxing stomach muscles and relieving pain, cramps, bloating etc. 

Pharmacokinetics:  

Absorption 

Hyoscine butylbromide is readily absorbed from the GI tract.  

Distribution 

The drug crosses the blood-brain barrier. The volume of distribution is 128L, and approximately 4% of the drug is bound to proteins. 

Metabolism 

Hyoscine butylbromide undergoes hepatic metabolism through conjuagtion 

Elimination and excretion 

Less than 10% of the unchanged drug is eliminated in urine. 42-61% of the drug as butybromide in unchanged form is eliminated through urine and 28-37% as feces.  

Half life: 

1. 4 hours 

Adminstartion

Administration: 

To be administered as directed by the physician 

Patient Information Leaflet

Patient information leaflet 

Generic Name: hyoscine butylbromide  

Why do we use hyoscine butylbromide? 

Hyoscine butylbromide is an anticholinergic agent. It is used to relieve spasms of the genitourinary and gastrointestinal tract, motion sickness, irritable bowel syndrome, nausea, vomiting, vertigo, etc.