iopromide

Action and Spectrum

Actions and Spectrum: 

Action: 

iopromide is a non-ionic, water-soluble contrast agent. Its primary action is to increase the radiodensity or radiopacity of the area it is administered to, allowing for better visualization in medical imaging. This contrast enhancement occurs due to the differential absorption of X-rays by tissues containing iopromide, compared to surrounding tissues. iopromide molecules contain iodine, which is highly effective at absorbing X-rays. When introduced into the bloodstream, it circulates throughout the body and accumulates in the target area, making it more visible in imaging. 

Spectrum: 

Computed Tomography (CT) Scans:
iopromide is commonly employed via intravenous administration to improve the contrast of blood vessels, organs, and various anatomical structures within the body when undergoing CT scans. It is particularly valuable in evaluating the vascular system, such as the arteries and veins. 

Angiography: ioipromide is extensively used in angiography, a specialized X-ray imaging technique for visualizing blood vessels. It helps diagnose and guide treatment for various vascular conditions, such as atherosclerosis, aneurysms, and blockages. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Dry mouth 

Numbness and tingling 

Pain 

Body aches 

Agitation 

Indigestion 

Abdominal pain 

vision changes 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity or Allergic Reactions: iopromide is contraindicated for individuals who have a known hypersensitivity or allergic response to the active ingredient, or any components found in the contrast medium. 

Severe Renal Impairment: iopromide can put additional stress on the kidneys as it is excreted primarily through renal pathways. It should be used cautiously or avoided in patients with severe renal impairment or acute kidney injury, as it may exacerbate kidney problems. 

Thyroid Dysfunction: iopromide can potentially interfere with thyroid function. Individuals with known thyroid disorders should be monitored closely, and alternative imaging agents may be considered. 

Heart Conditions: Patients with severe heart conditions, particularly those at risk of fluid overload, should be carefully evaluated before administering iopromide, as the volume of contrast medium can strain the cardiovascular system. 

Pregnancy and Lactation: iopromide should be used during pregnancy or lactation only when the potential benefits outweigh the potential risks, and under the supervision of a healthcare provider. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: AU TGA pregnancy category: B2
US FDA pregnancy category: Not assigned 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology: iopromide is a contrast agent used in medical imaging procedures, particularly in radiographic and computed tomography (CT) scans. 

Pharmacodynamics:  

Radiopacity: 

iopromide is radiopaque, meaning it absorbs and scatters X-rays. This property allows it to enhance the visibility of blood vessels and soft tissues during imaging procedures. It appears white on X-ray images, while surrounding tissues appear darker.  

Pharmacokinetics: 

Absorption 

After intravascular administration, iopromide is rapidly distributed throughout the vascular system, enhancing the contrast of blood vessels and surrounding tissues. 

Distribution 

iopromide is distributed throughout the body via the bloodstream. It is a water-soluble contrast agent, which means it mainly remains in the vascular system and extracellular spaces. It does not cross the blood-brain barrier or readily enter other compartments within the body. 

Metabolism 

iopromide is primarily eliminated unchanged through renal excretion. It is not metabolized in the body, which simplifies its elimination pathway. 

Excretion and Elimination 

The kidneys play a crucial role in the elimination of iopromide. It is filtered through the glomerulus and excreted in the urine. 

Adminstartion

Administration:  

The dosage of iopromide is determined based on the specific imaging procedure, the patient’s weight, and renal function. The exact dosage is at the discretion of the radiologist or healthcare provider. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: iopromide 

Why do we use iopromide?  

In contrast-enhanced CT scans, iopromide is commonly used to increase the visibility of blood vessels, organs, and tissues. This helps in the diagnosis and monitoring of various medical conditions, such as tumors, vascular abnormalities, and inflammatory diseases. 

iopromide is used in angiography, a medical imaging technique that involves the visualization of blood vessels, such as coronary angiography (for the heart), cerebral angiography (for the brain), and peripheral angiography (for the limbs). It helps identify blockages, aneurysms, and other vascular abnormalities.