Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Symdeko
Synonyms :
ivacaftor/tezacaftor
Class :
CFTR Potentiators and combos
Brand Name :
Symdeko
Synonyms :
ivacaftor/tezacaftor
Class :
CFTR Potentiators and combos
Dosage Forms & Strengths
Copackaged tablets
Fixed dose of tezacaftor 100mg and ivacaftor 150mg + a separate ivacaftor 150mg
tezacaftor 100 mg/ivacaftor 150 mg of 1 tablet orally in the morning and ivacaftor 150 mg 1 tablet orally in the evening
Dosages should be taken in the morning and evening, 12 hours apart
Dosage Forms & Strengths
Copackaged tablets
Fixed dose of tezacaftor 100mg and ivacaftor 150mg + a separate ivacaftor 150mg
Age: 6-<12 years; wt <30 kg
tezacaftor 50 mg/ivacaftor 75 mg of 1 tab orally in the morning and ivacaftor 75 mg of 1 tab orally in the evening
Dosages should be taken in the morning and evening, 12 hours apart
Age: ≥6 years; wt ≥30 kg
tezacaftor 100 mg/ivacaftor 150 mg of 1 tab orally in the morning and ivacaftor 150 mg of 1 tab orally in the evening
Dosages should be taken in the morning and evening, 12 hours apart
may increase the levels of serum concentration of ivacaftor/tezacaftor
may increase the levels of serum concentration of ivacaftor/tezacaftor
may increase the levels of serum concentration of ivacaftor/tezacaftor
may increase the levels of serum concentration of ivacaftor/tezacaftor
may increase the levels of serum concentration of ivacaftor/tezacaftor
Adverse drug reactions
Frequency Defined
>10%
Headache
1-10%
Dizziness (4%)
Sinus congestion (4%)
Nausea (9%)
Pregnancy warnings:
AU TGA pregnancy category: B3
US FDA pregnancy category: Not assigned
Lactation:
Excreted into human milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: ivacaftor/tezacaftor
Why do we use ivacaftor/tezacaftor?
ivacaftor/tezacaftor is a CFTR Potentiators and combos used to treat cystic fibrosis.
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