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Brand Name :
Teslascan
Synonyms :
mangafodipir
Class :
Magnetic resonance imaging contrast media
Brand Name :
Teslascan
Synonyms :
mangafodipir
Class :
Magnetic resonance imaging contrast media
Dosage Forms & Strengths
Solution for infusion
0.5 ml/kg bodyweight
Indicated for Diagnostic Magnetic Resonance Imaging:
For imaging of the liver, it should be given as an intravenous infusion at a rate of 2 to 3 ml/min and imaging of the pancreas at a rate of 4 to 6 ml/min.
The recommended dose is 0.5 ml/kg bodyweight (5 μmol/kg bodyweight).
This corresponds to a dose of 35 ml for a 70 kg person.
Above 100 kg body weight, 50 ml is usually sufficient to provide a diagnostically adequate contrast effect.
Safety and efficacy not established
Refer adult dosing
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion which could result in a higher serum level
may diminish the rate of excretion which results in a higher serum level
may diminish the rate of excretion which results in a higher serum level
may diminish the rate of excretion which results in a higher serum level
may diminish the rate of excretion which results in a higher serum level
may diminish the rate of excretion which results in a higher serum level
may diminish the rate of excretion when combined with each other
may diminish the rate of excretion when combined with each other
may diminish the rate of excretion when combined with each other
Actions and Spectrum:
Frequency not defined
Irregular heartbeat
Shortness of breath
Swelling of face
Chest pain
Itching
Skin rash or hives
Black box warning:
None
Contraindications/caution:
Contraindications:
Caution:
Pregnancy consideration: Insufficient data available
Lactation: The excretion of the drug in human breast milk is unknown. From the moment teslascan is administered, breastfeeding should be stopped and shouldn’t be started again for 14 days.
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
mangafodipir functions as a paramagnetic contrast agent. The manganese ions in the mangafodipir complex have unpaired electrons, making them paramagnetic.
When exposed to a magnetic field, such as that generated by an MRI machine, paramagnetic ions alter nearby tissues’ magnetic properties. This leads to changes in the relaxation times of surrounding water protons, enhancing the contrast between different tissues in the MRI images.
The paramagnetic properties of mangafodipir contribute to its ability to shorten the T1 and T2 relaxation times of water protons in tissues where the contrast agent accumulates. This results in brighter signal intensity in the MRI images and improved visualization of specific structures.
Pharmacokinetics:
Absorption
mangafodipir is administered intravenously, meaning it is directly introduced into the bloodstream. This route of administration allows for rapid and direct distribution of the contrast agent throughout the body.
Distribution
After administration, mangafodipir dissociates into its components, including manganese ions and the fodipir ligand. Manganese ions are distributed throughout the body and can be taken up by various tissues. The liver, in particular, plays a role in the metabolism and excretion of manganese.
Metabolism
mangafodipir’s components, including manganese ions, might undergo metabolism in the body. Manganese ions could be involved in various cellular processes and interactions within tissues.
Elimination and Excretion
The excretion of manganese ions occurs through both hepatobiliary (liver and bile) and urinary pathways. Manganese is primarily eliminated via the liver, and a portion is excreted in the urine.
Administration:
Intravenous administration
The contrast agent is administered as a slow intravenous injection through the IV line. The rate of injection is controlled to prevent adverse reactions.
Patient information leaflet
Generic Name: mangafodipir
Why do we use mangafodipir?
mangafodipir, known by the trade name “Teslascan,” is a contrast agent used in magnetic resonance imaging (MRI) procedures. It contains manganese ions and enhances the visibility of specific tissues and structures during MRI scans.
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